scholarly journals Phylodynamic and Phylogeographic Analysis of Hepatitis Delta Virus Genotype 3 Isolated in South America

Viruses ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 995 ◽  
Author(s):  
Felipe Souza Nogueira-Lima ◽  
Luan Felipo Botelho-Souza ◽  
Tárcio Peixoto Roca ◽  
Alcione Oliveira dos Santos ◽  
Suyane da Costa Oliveira ◽  
...  
Keyword(s):  
South America ◽  
Hepatitis Delta Virus ◽  
Recent Common Ancestor ◽  
Screening Methods ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Serological Screening ◽  
Hepatitis Delta ◽  
Most Recent Common Ancestor ◽  
Delta Virus

The hepatitis delta virus (HDV) is a globally distributed agent, and its genetic variability allows for it to be organized into eight genotypes with different geographic distributions. In South America, genotype 3 (HDV-3) is frequently isolated and responsible for the most severe form of infection. The objective of this study was to evaluate the evolutionary and epidemiological dynamics of HDV-3 over the years and to describe its distribution throughout this continent in an evolutionary perspective. While using Bayesian analysis, with strains being deposited in the Nucleotide database, the most recent common ancestor was dated back to 1964 and phylogenetic analysis indicated that the dispersion may have started in Brazil, spreading to Venezuela and then to Colombia, respectively. Exponential growth in the effective number of infections was observed between the 1950s and 1970s, years after the first report of the presence of HDV on the continent, during the Labrea Black Fever outbreak, which showed that the virus continued to spread, increasing the number of cases decades after the first reports. Subsequently, the analysis showed a decrease in the epidemiological levels of HDV, which was probably due to the implantation of the vaccine against its helper virus, hepatitis B virus, and serological screening methods implemented in the blood banks.

scholarly journals Treatment of hepatitis delta virus genotype 3 infection with peg-interferon and entecavir

2016 ◽  
Vol 46 ◽  
pp. 82-88 ◽  
Author(s):  
Lourdes Maria Pinheiro Borzacov ◽  
Larissa Deadame de Figueiredo Nicolete ◽  
Luan Felipo Botelho Souza ◽  
Alcione Oliveira dos Santos ◽  
Deusilene Souza Vieira ◽  
...  
Keyword(s):  
Hepatitis Delta Virus ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Hepatitis Delta ◽  
Delta Virus

Phylogeography and evolutionary history of hepatitis E virus genotype 3 in Argentina

2021 ◽  
Author(s):  
María B Pisano ◽  
Andrés C A Culasso ◽  
Nancy Altabert ◽  
Maribel G Martínez Wassaf ◽  
Silvia V Nates ◽  
...  
Keyword(s):  
Evolutionary History ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Recent Common Ancestor ◽  
Genotype 3 ◽  
Posterior Density ◽  
Virus Genotype ◽  
Most Recent Common Ancestor ◽  
History Of ◽  
Highest Posterior Density

Abstract Background Few studies about the evolutionary history of the hepatitis E virus (HEV) have been conducted. The aim of our work was to investigate and make inferences about the origin and routes of dispersion of HEV-3 in Argentina. Methods Phylogenetic, coalescent and phylogeographic analyses were performed using a 322-bp ORF2 genomic fragment of all HEV-3 sequences with known date and place of isolation published at GenBank until May 2018 (n=926), including 16 Argentinian sequences (isolated from pigs, water and humans). Results Phylogenetic analysis revealed two clades within HEV-3: abchij and efg. All Argentinian samples were grouped intermingled within clade 3abchij. The coalescent analysis showed that the most recent common ancestor for the clade 3abchij would have existed around the year 1967 (95% highest posterior density (HPD): 1963–1970). The estimated substitution rate was 1.01×10−2 (95%HPD: 9.3×10ˉ3–1.09×10ˉ2) substitutions/site/y, comparable with the rate previously described. The phylogeographic approach revealed a correspondence between phylogeny and place of origin for Argentinian samples, suggesting many HEV introductions in the country, probably from Europe and Japan. Conclusions This is the first evolutionary inference of HEV-3 that includes Argentinian strains, showing the circulation of many HEV-3 subtypes, obtained from different sources and places, with recent diversification processes. Accession numbers [KX812460], [KX812461], [KX812462], [KX812465], [KX812466], [KX812467], [KX812468], [KX812469].

Hepatitis delta virus genotypes I and III circulate associated with hepatitis B virus genotype F In Venezuela

2001 ◽  
Vol 64 (3) ◽  
pp. 356-359 ◽  
Author(s):  
Alberto Quintero ◽  
Nathalie Uzcátegui ◽  
Carmen Luisa Loureiro ◽  
Leopolodo Villegas ◽  
Ximena Illarramendi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Virus Genotype ◽  
Hepatitis Delta ◽  
B Virus ◽  
Virus Genotypes ◽  
Genotype F ◽  
Delta Virus

Hepatitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan

1999 ◽  
Vol 58 (4) ◽  
pp. 366-372 ◽  
Author(s):  
Hiroshi Sakugawa ◽  
Hiroki Nakasone ◽  
Tomofumi Nakayoshi ◽  
Yuko Kawakami ◽  
Shiro Miyazato ◽  
...  
Keyword(s):  
Hepatitis Delta Virus ◽  
Endemic Area ◽  
Virus Genotype ◽  
Hepatitis Delta ◽  
Delta Virus

scholarly journals Clinical evolution of hepatitis delta virus genotype 3 infection in patients from the Western Amazon, Brazil

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Suyane da Costa Oliveira ◽  
◽  
Eugênia de Castro Silva ◽  
Miriam Ribas Zambenedetti ◽  
Soraya dos Santos Pereira ◽  
...  
Keyword(s):  
Viral Load ◽  
Viral Replication ◽  
Hepatitis Delta Virus ◽  
Inactive Disease ◽  
Virus Genotype ◽  
Endemic Region ◽  
Hepatitis Delta ◽  
Hepatitis D ◽  
Clinical Evolution ◽  
Delta Virus

Background: Chronic infection with the Hepatitis Delta Virus (HDV) is often associated with severe liver decompensation and fulminant hepatitis, but in some cases, it can present a stable clinical presentation. Objectives: This study evaluated the clinical evolution of HDV-3 carriers from an endemic region of the western Brazilian Amazon. Methods: Cross-sectional study was carried out with Anti-HDAg reagent patients, seen at an outpatient clinic specialized in viral hepatitis located in Rondônia, Brazil. Findings: A total of 19 patients, 68.4% male and 31.6% female, aged between 23 and 65 years old, were evaluated; 84.2% were clinically classified as carriers of the decompensated disease and 15.8% as carriers of the inactive disease. The results of the clinical evaluation were related to viral load; 30.8% had detectable viral RNA, and even though it was not possible to establish an association between the stage of the disease and persistent viral replication (p> 0.05), persistent viral replication was predictive of early evolution for liver cirrhosis. Conclusion: The results demonstrate the possibility that viral load can be used as a noninvasive hepatic marker in the clinical management of Hepatitis Delta. Keywords: chronic; hepatitis D; hepatitis delta virus; liver diseases.

scholarly journals The predominance of hepatitis delta virus genotype I among chronically infected Italian patients

Hepatology ◽  
1997 ◽  
Vol 25 (3) ◽  
pp. 728-734 ◽  
Author(s):  
G A Niro ◽  
A Smedile ◽  
A Andriulli ◽  
M Rizzetto ◽  
J L Gerin ◽  
...  
Keyword(s):  
Hepatitis Delta Virus ◽  
Virus Genotype ◽  
Genotype I ◽  
Hepatitis Delta ◽  
Delta Virus
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