scholarly journals Effects of the HN Antigenic Difference between the Vaccine Strain and the Challenge Strain of Newcastle Disease Virus on Virus Shedding and Transmission

Viruses ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 225 ◽  
Author(s):  
Jingjing Liu ◽  
Jie Zhu ◽  
Haixu Xu ◽  
Juan Li ◽  
Zenglei Hu ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Newcastle Disease ◽  
Antigenic Difference ◽  
Virus Shedding ◽  
Challenge Strain

scholarly journals Interaction between avian influenza subtype H9N2 and Newcastle disease virus vaccine strain (LaSota) in chickens

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Hany F. Ellakany ◽  
Ahmed R. Gado ◽  
Ahmed R. Elbestawy ◽  
Hatem S. Abd El-Hamid ◽  
Hafez M. Hafez ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Virus Vaccine ◽  
Newcastle Disease ◽  
Newcastle Disease Virus Vaccine

Identification of Two Distinct Linear B Cell Epitopes of the Matrix Protein of the Newcastle Disease Virus Vaccine Strain LaSota

2019 ◽  
Vol 32 (5) ◽  
pp. 221-229 ◽  
Author(s):  
Youkun Bi ◽  
Zhongyuan Jin ◽  
Yanhong Wang ◽  
Sujing Mou ◽  
Wenbin Wang ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
B Cell ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Virus Vaccine ◽  
Newcastle Disease ◽  
Matrix Protein ◽  
B Cell Epitopes ◽  
The Matrix ◽  
Newcastle Disease Virus Vaccine

scholarly journals Sequence of the haemagglutinin‐neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM)

1996 ◽  
Vol 25 (4) ◽  
pp. 837-844 ◽  
Author(s):  
Khatijah Yusoff ◽  
Wen Siang Tan ◽  
Chin Hoon Lau ◽  
Ban Kim Ng ◽  
Abdul Latif Ibrahim
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Newcastle Disease ◽  
Oral Vaccine

Evaluation of the oncolytic potential of R2B Mukteshwar vaccine strain of Newcastle disease virus (NDV) in a colon cancer cell line (SW-620)

2017 ◽  
Vol 162 (9) ◽  
pp. 2705-2713 ◽  
Author(s):  
Kishan K. Sharma ◽  
Irsadullakhan H. Kalyani ◽  
Jogeswar Mohapatra ◽  
Satish D. Patel ◽  
Dharmesh R. Patel ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Newcastle Disease Virus ◽  
Cell Line ◽  
Disease Virus ◽  
Cancer Cell ◽  
Vaccine Strain ◽  
Newcastle Disease ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell

scholarly journals In-ovo Newcastle disease virus vaccine strain TS09-C protects commercial chickens against Newcastle disease in the presence of maternally derived antibodies

2020 ◽  
Vol 99 (5) ◽  
pp. 2438-2443
Author(s):  
Sanling Fan ◽  
Yulun Wu ◽  
Hongling Wang ◽  
Yu Shang ◽  
Qingping Luo ◽  
...  
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Virus Vaccine ◽  
Newcastle Disease ◽  
In Ovo ◽  
Newcastle Disease Virus Vaccine ◽  
Commercial Chickens

scholarly journals Generation of recombinant lentogenic Newcastle disease virus from cDNA

1999 ◽  
Vol 80 (11) ◽  
pp. 2987-2995 ◽  
Author(s):  
Angela Römer-Oberdörfer ◽  
Egbert Mundt ◽  
Teshome Mebatsion ◽  
Ursula J. Buchholz ◽  
Thomas C. Mettenleiter
Keyword(s):  
Rna Polymerase ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Newcastle Disease ◽  
T7 Rna Polymerase ◽  
Wild Type Virus ◽  
Progeny Virus ◽  
Restriction Sites ◽  
Specific Pathogen

Recombinant lentogenic Newcastle disease virus (NDV) of the vaccine strain Clone-30 was reproducibly generated after simultaneous expression of antigenome-sense NDV RNA and NDV nucleoprotein, phosphoprotein and RNA-dependent RNA polymerase from plasmids transfected into cells stably expressing T7 RNA polymerase. For this purpose, the genome of Clone-30, comprising 15186 nt, was cloned and sequenced prior to assembly into a full-length cDNA clone under control of a T7 RNA polymerase promoter. Recombinant virus was amplified by inoculation of transfection supernatant into the allantoic cavity of embryonated specific-pathogen-free (SPF) chicken eggs. Two marker restriction sites comprising a total of five nucleotide changes artificially introduced into noncoding regions were present in the progeny virus. The recombinant NDV was indistinguishable from the parental wild-type virus with respect to its growth characteristics in cell culture and in embryonated eggs. Moreover, an intracerebral pathogenicity index of 0·29 was obtained for both viruses as determined by intracerebral inoculation of day-old SPF chickens, proving that the recombinant NDV is a faithful copy of the parental vaccine strain of NDV.

scholarly journals Immunoinformatics analysis and antibody epitope comparison of Newcastle disease virus classical vaccines with a virus involved in the fifth NDV panzootic

2021 ◽  
Author(s):  
Seyed-Elias Tabatabaeizadeh
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Vaccine Strain ◽  
Newcastle Disease ◽  
Neutralizing Antibodies ◽  
3D Structure ◽  
Live Vaccines ◽  
Field Virus ◽  
Inactivated Vaccines ◽  
Antibody Epitopes

Abstract Newcastle disease virus (NDV) has negatively affected the poultry industry worldwide. Given that the antigenic similarity of a vaccine strain to a field virus is effective in protection, an immunoinformatics study was performed to examine the similarity between antibody epitopes of classical vaccines and a sub-genotype VII.2 NDV (VII.2 NDV). Considering the role of fusion (F) and hemagglutinin-neuraminidase (HN) proteins in the induction of neutralizing antibodies, the 3D structure of HN and F proteins of the VII.2 NDV and nine vaccine strains were predicted, refined, and validated. Using these structures, linear and conformational antibody epitopes were mapped. Epitope analysis showed distinct results from the evolutionary distance and protein identity analysis and it was found that the range of difference in the number of identical epitopes in relation to F is wider than HN protein. LaSota and B1 vaccine strains showed the least epitope identity to the VII.2 NDV. The V4 and I-2 vaccine strains showed the highest epitope identity with the VII.2 NDV especially in F protein which is important in virus cell-to-cell transmission. In conclusion, excellence of the LaSota vaccine under field condition shows that protection is not just about epitope similarities and especially in the case of live vaccines, the vaccine-induced damage, replicative capacity and tropism of the vaccine strain are important. The prediction of this study may be useful for inactivated vaccines in which the amount of antigen is all that matters.

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