scholarly journals Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases

2021 ◽  
Vol 8 (7) ◽  
pp. 136
Author(s):  
Julia Maria Grassinger ◽  
Andreas Floren ◽  
Tobias Müller ◽  
Argiñe Cerezo-Echevarria ◽  
Christoph Beitzinger ◽  
...  
Keyword(s):  
Bone Tumors ◽  
Soft Tissue Sarcomas ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Routine Diagnostics ◽  
Mast Cell Tumors ◽  
Neoplastic Processes ◽  
Study Population ◽  
Tumor Like Lesions ◽  
Labrador Retrievers

Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = −2.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = −2.17), Jack Russell Terriers (log OR = −1.88), and Rhodesian Ridgebacks (log OR = −1.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or “resistance” to the development of specific acral tumors and/or other sites.

scholarly journals Parapharyngeal space tumors: considerations in 26 cases

1999 ◽  
Vol 117 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Alfio José Tincani ◽  
Antonio Santos Martins ◽  
Albina Altemani ◽  
Rui Carlos Scanavini Jr. ◽  
Gilson Barreto ◽  
...  
Keyword(s):  
Parapharyngeal Space ◽  
Malignant Tumors ◽  
Soft Tissue Sarcomas ◽  
Needle Aspiration ◽  
High Rate ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Surgical Morbidity ◽  
Neurogenic Tumors ◽  
Parapharyngeal Space Tumors

CONTEXT: Parapharyngeal space tumors comprise less than 0.5% of all head and neck neoplasms.1 The majority of these tumors are benign, but surgery is usually required to establish the diagnosis and treat the patients. We present 26 patients treated surgically for tumors arising in the parapharyngeal space (PPS) at the State University of Campinas Hospital – UNICAMP. CASES SERIE: Of these, 17 (65.5%) had benign and 9 (34.6%) malignant neoplasms. The surgical and pathological data relevant to these cases are highlighted, observing any local recurrence, surgical complications and the five-year survival. Neurogenic tumors and soft tissue sarcomas were, respectively, the most frequent benign (35.3%) and malignant neoplasms (44.5%). Benign tumors accounted for the majority of the cases and involved minimal surgical morbidity with no recurrence during a median follow-up of five years. Malignant tumors had a high rate of recurrence and mortality. Surgery is the treatment of choice for PPS tumors. A knowledge of the anatomy of this site is essential for the safe performance of surgical procedures. Malignant neoplasms have a poor prognosis. Fine needle aspiration was helpful in diagnosis of all tumors.

scholarly journals Prevalence of tumor pathology of dogs in the metropolis

2021 ◽  
Vol 9 (2) ◽  
pp. 98-104
Author(s):  
G. V. Samoilіuk
Keyword(s):  
Bone Neoplasms ◽  
Soft Tissue Sarcomas ◽  
Skin Neoplasms ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Tumor Pathology ◽  
Hind Limbs ◽  
Oncological Diseases ◽  
Myxoid Liposarcomas ◽  
The City

A statistical analysis of the prevalence of tumor pathology of dogs in the city of Dnipro. 418 cases of registered oncological diseases of dogs were analyzed. It was found that malignant neoplasms are 1.5 times more common than benign. The most common tumors in dogs are tumors of the breast (35,9%), skin (22,0%), genitals (15,3%) and lymphoma(8,4%). Malignant neoplasms of the breast are registered 3.6 times more often than benign and surpass them in morphological varieties. Fibroadenomas and infiltrating and non-infiltrating carcinomas were mainly registered. Approximately the same number of cases of infiltrating and non-infiltrating cancers were noted. Benign skin tumors are more common than malignant. Mastocytosis, melanoma, and squamous and basal cell carcinomas of the skin and sebaceomas were the most commonly reported. In terms of morphological varieties, benign skin neoplasms are superior to malignant ones. Lipomas and papillomas are very common. Genital neoplasms of females and males are also common. Almost half of male genital tumors were malignant seminomas. Among benign neoplasms, serteliomas and leydigomas were more common. In females, the most common are uterine leiomyoma, vaginal fibroma and ovarian carcinoma. Lymphomas (8.4%) are also widespread in dogs in the metropolis. The average age of registration of these neoplasms was 7.5 years. Benign tumors in the oral cavity of dogs were twice as common as malignant, of which fibrosarcomas, squamous keratinized and non-keratinized carcinomas, and salivary gland adenocarcinomas were reported. In females, oral neoplasia occurred 3.2 times more often than in males. Only malignant venereal sarcomas and carcinomas were found in the nasal cavity of dogs. Sexual and pedigree predisposition was not observed here. Among neoplasms of muscles and bones there was only a malignant oncological pathology. Rhabdomyosarcomas, fibrosarcomas, myxoid liposarcomas and other soft tissue sarcomas were diagnosed in different parts of the dog’s body. Bone neoplasms are represented by osteosarcomas. Dogs of large breeds were most often affected and in most cases the hind limbs were affected. The predominant histological subtype was osteoblastic osteosarcoma.

Medical Care for Children with Cancer in the Donetsk People’s Republic: Results of an Ecological Study in 2014–2017

2018 ◽  
Vol 5 (3) ◽  
pp. 145-154
Author(s):  
M. Yu. Rykov ◽  
I. N. Inozemtsev ◽  
S. A. Kolomenskaya
Keyword(s):  
Medical Care ◽  
Pediatric Patient ◽  
Ecological Study ◽  
Medical Service ◽  
Care Delivery ◽  
Benign Tumors ◽  
High Tech ◽  
Malignant Neoplasms ◽  
Children With Cancer ◽  
Patient Capacity

Background.Analysis of medical care delivery for children with cancer in armed conflict is highly important because the high-tech treatment in this context is extraordinary difficult and challenging task. Objective. Our aim was to analyze the morbidity and mortality rates in children with malignant tumors, to assess the pediatric patient capacity and medical service density in the Donetsk People’s Republic.Methods.The ecological study was conducted where the units of analysis were represented by the aggregated data of the Republican Cancer Registry on the number of primary and secondary patients with malignant and benign tumors, the deceased patients in the DNR in 2014–2017, pediatric patient capacity, and medical service density.Results.The number of pediatric patient capacity for children with cancer was 10 (0.27 per 10,000 children aged 0–17), pediatric patient capacity for children with hematological disorders — 40 (1.37 per 10,000 children aged 0–17). The treatment of children with cancer was performed by 5 healthcare providers: 1 pediatric oncologist (0.02 per 10,000 children aged 0–17), 3 hematologists (0.08 per 10,000 pediatric population aged 0–17), and 1 practitioner who did not have a specialist certificate in oncology. Morbidity rate for malignant neoplasms from 2014 to 2017 decreased by 25% (in 2014 — 9.6 per 10,000 children aged 0–17; in 2017 — 7.2). In the morbidity structure, the incidence proportion of hemoblastoses was 68.4%, brain tumors — 2.6%, other solid tumors — 29%. The death rate due to malignant neoplasms decreased by 37% (in 2014 — 2.7; in 2017 — 1.7).Conclusion.Low levels of the incidence rate and pattern of morbidity indicate defects in the identification and recording of patients. This explains the performance of the bed: low average bed occupancy per year and low turnover. For a reliable analysis of mortality statistical data is not available: in 2014–2015 only the number of in-hospital deceased patients is presented. Limited data is due to the lack of reliable patient catamnesis which is explained by the high rate of population migration. 

scholarly journals Preliminary results of Highly Injectable Bi-Phasic Bone Substitute (CERAMENT) in the treatment of benign bone tumors and tumor-like lesions

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 487-492 ◽  
Author(s):  
Daniel Kotrych ◽  
Szymon Korecki ◽  
Paweł Ziętek ◽  
Bartosz Kruk ◽  
Agnieszka Kruk ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Bone Tumors ◽  
Bone Cyst ◽  
Bone Diseases ◽  
Long Term Results ◽  
Reconstructive Procedures ◽  
Benign Bone Tumors ◽  
Significant Clinical Improvement ◽  
Tumor Like Lesions

AbstractBackground: CERAMENT™|BONE VOID FILLER is an injectable and moldable ceramic bone substitute material intended for bone voids. The material consists of hydroxyapatite and calcium sulfate hemihydrate. The aim of this study is to present the first long-term results following open curettage of benign bone tumors and tumor-like lesions and void filling with this novel injectable and synthetic bone graft. Methods: Thirty three patients were enrolled into the study between June 2013 and October 2014 .Totally, we treated 24 women and 9 men with a median age of 47 years (range: 22-74). All patients suffered from primary musculoskeletal system disorders (enchondroma 63,6%, giant cell tumor 18%, aneurysmal bone cyst 9%, fibrous dysplasia 9%, Gaucher disease 3%). We performed curettage of pathological lesions, then the bone substitute was administered by means of needle to the void. Results: The average follow-up was 13 months (range: 2-13 months, median 10 months). No metastasis or recurrence had been detected. We received significant clinical improvement relating to VAS, MSTS, and oncological results. Conclusions: The results of our study report that CERAMENT can be successfully used as a bone substitute in patients with various bone diseases, as well as benign bone tumors. CERAMENT can provide an effective and long-term solution for reconstructive procedures following curettage of bone tumors and tumor like lesions.

scholarly journals Cutaneous Tumors in Swiss Dogs: Retrospective Data From the Swiss Canine Cancer Registry, 2008–2013

2018 ◽  
Vol 55 (6) ◽  
pp. 809-820 ◽  
Author(s):  
Ramona Graf ◽  
Andreas Pospischil ◽  
Franco Guscetti ◽  
Daniela Meier ◽  
Monika Welle ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nova Scotia ◽  
Cancer Registry ◽  
Soft Tissue Sarcomas ◽  
Population Data ◽  
Cancer Registries ◽  
Mast Cell Tumors ◽  
Melanocytic Tumors ◽  
Canine Cancer ◽  
Tumor Types

Data collected in animal cancer registries comprise extensive and valuable information, even more so when evaluated in context with precise population data. The authors evaluated 11 740 canine skin tumors collected in the Swiss Canine Cancer Registry from 2008–2013, considering data on breed, sex, age, and anatomic locations. Their incidence rate (IR) per 100 000 dogs/year in the Swiss dog population was calculated based on data from the official and mandatory Swiss dog registration database ANIS. The most common tumor types were mast cell tumors (16.35%; IR, 60.3), lipomas (12.47%; IR, 46.0), hair follicle tumors (12.34%; IR, 45.5), histiocytomas (12.10%; IR, 44.6), soft tissue sarcomas (10.86%; IR, 40.1), and melanocytic tumors (8.63%; IR, 31.8) with >1000 tumors per type. The average IR of all tumor types across the 227 registered breeds was 372.2. The highest tumor incidence was found in the Giant Schnauzer (IR, 1616.3), the Standard Schnauzer (IR, 1545.4), the Magyar Vizsla (IR, 1534.6), the Rhodesian Ridgeback (IR, 1445.0), the Nova Scotia Duck Tolling Retriever (IR, 1351.7), and the Boxer (IR, 1350.0). Mixed-breed dogs (IR, 979.4) had an increased IR compared to the average of all breeds. Previously reported breed predispositions for most tumor types were confirmed. Nevertheless, the data also showed an increased IR for mast cell tumors and melanocytic tumors in the Nova Scotia Duck Tolling Retriever and for histiocytomas in the Flat Coated Retriever. The results from this study can be taken into consideration when selecting purebred dogs for breeding to improve a breed’s health.

scholarly journals KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimickers

2020 ◽  
Author(s):  
Lucen Jiang ◽  
Jianghuan Liu ◽  
Qingzhu Wei ◽  
Yiyang Wang
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Diagnostic Value ◽  
Benign Tumors ◽  
Malignant Bone Tumor ◽  
Malignant Bone Tumors ◽  
Potential Marker ◽  
Tumors Of Bone ◽  
Bone Sarcomas ◽  
Malignant And Benign Tumors

Abstract Background Karyopherin α 2 (KPNA2), a member of the Karyopherin α family, has been observed in several cancers but lack substantial investigation in malignant bone tumors. The purpose of the current study was to evaluate KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and their malignant bone tumor mimickers, such as chondrosarcomas and Ewing sarcomas.Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin embedded surgical specimens from 217 patients with malignant and benign tumors of bone, including 81 osteosarcomas, 42 chondrosarcomas, 9 Ewing sarcomas, 28 osteoid osteoma, 20 osteochondroma and 37 Chondroblastoma. Immunoreactivity was scored semi quantitatively based on stain extent and intensity.Results Seventy one of 81 (87.7%) osteosarcomas, zero of 42 (0%) chondrosarcomas and one of 9 (11.1%) Ewing sarcomas showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all of benign bone tumors. Much more positive expression of KPNA2 was found in osteosarcomas as compared with chondrosarcomas and Ewing sarcomas. The sensitivity and specificity of KPNA2 immuno-expression for osteosarcoma was 87.7% and 100%, respectively. In several subtypes of osteosarcomas, immunohistochemical expression of KNA2 was more frequent in osteoblastic (94.5%), with 39 (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in eleven of 13 (84.6%) chondroblastic, three of 6 (50%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma. Stronger-intensity staining was observed in osteoblastic osteosarcoma.Conclusion KPNA2 is most frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and Ewing sarcomas. This feature may have diagnostic value since it is very useful for distinguishing between osteosarcomas and other bone sarcomas mimickers. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

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