scholarly journals Cutaneous Tumors in Swiss Dogs: Retrospective Data From the Swiss Canine Cancer Registry, 2008–2013

2018 ◽  
Vol 55 (6) ◽  
pp. 809-820 ◽  
Author(s):  
Ramona Graf ◽  
Andreas Pospischil ◽  
Franco Guscetti ◽  
Daniela Meier ◽  
Monika Welle ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nova Scotia ◽  
Cancer Registry ◽  
Soft Tissue Sarcomas ◽  
Population Data ◽  
Cancer Registries ◽  
Mast Cell Tumors ◽  
Melanocytic Tumors ◽  
Canine Cancer ◽  
Tumor Types

Data collected in animal cancer registries comprise extensive and valuable information, even more so when evaluated in context with precise population data. The authors evaluated 11 740 canine skin tumors collected in the Swiss Canine Cancer Registry from 2008–2013, considering data on breed, sex, age, and anatomic locations. Their incidence rate (IR) per 100 000 dogs/year in the Swiss dog population was calculated based on data from the official and mandatory Swiss dog registration database ANIS. The most common tumor types were mast cell tumors (16.35%; IR, 60.3), lipomas (12.47%; IR, 46.0), hair follicle tumors (12.34%; IR, 45.5), histiocytomas (12.10%; IR, 44.6), soft tissue sarcomas (10.86%; IR, 40.1), and melanocytic tumors (8.63%; IR, 31.8) with >1000 tumors per type. The average IR of all tumor types across the 227 registered breeds was 372.2. The highest tumor incidence was found in the Giant Schnauzer (IR, 1616.3), the Standard Schnauzer (IR, 1545.4), the Magyar Vizsla (IR, 1534.6), the Rhodesian Ridgeback (IR, 1445.0), the Nova Scotia Duck Tolling Retriever (IR, 1351.7), and the Boxer (IR, 1350.0). Mixed-breed dogs (IR, 979.4) had an increased IR compared to the average of all breeds. Previously reported breed predispositions for most tumor types were confirmed. Nevertheless, the data also showed an increased IR for mast cell tumors and melanocytic tumors in the Nova Scotia Duck Tolling Retriever and for histiocytomas in the Flat Coated Retriever. The results from this study can be taken into consideration when selecting purebred dogs for breeding to improve a breed’s health.

Shaved margin histopathology and imprint cytology for assessment of excision in canine mast cell tumors and soft tissue sarcomas

2017 ◽  
Vol 46 (6) ◽  
pp. 879-885 ◽  
Author(s):  
Milan Milovancev ◽  
Kaitlin L. Townsend ◽  
Elena Gorman ◽  
Shay Bracha ◽  
Katie Curran ◽  
...  
Keyword(s):  
Mast Cell ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Imprint Cytology ◽  
Mast Cell Tumors

Pediatric Cancer Registry in Turkey 2009-2018 (TPOG & TPHD).

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e21510-e21510
Author(s):  
M. Tezer Kutluk ◽  
Akif Yeşilipek
Keyword(s):  
Childhood Cancer ◽  
Children And Adolescents ◽  
Cancer Registry ◽  
Pediatric Cancer ◽  
Health Care Professionals ◽  
Survival Rates ◽  
Age Distribution ◽  
Soft Tissue Sarcomas ◽  
Cancer Registries ◽  
Term Survival

e21510 Background: In Children and adolescents aged 0-14, each year more than 200.000 new cancer cases are expected at global level. For the planning and implementation of an effective pediatric cancer control program, pediatric cancer registries are essential. The long term survival rates have been improved to 85% in high income countries, however it is still less than this in LMICs. This work presents the most updated results of the pediatric cancer registry in Turkey. Methods: Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Association has established the Pediatric Cancer Registry in 2002. The childhood cancer cases registered between 2009-2018 was included in this analysis. International Childhood Cancer Classification System was used for the classification. Essential demographic findings, ICD-O-3 morphology and topography codes were recorded for each case. Results: During the 10 years from 2009 to 2018, 15713 cases were registered. For all cases, median age was 6.7 year (0-17; M/F 8838/6867, 3 hermaphrodite, 5 unknown). Age distribution was 0-4 yrs, 40.7%; 5-9 yrs, 24.4%; 10-14 yrs, 23.2%; 15-19 yrs, 11.7%) The distribution of the tumor types were [number of cases, percentage of total, median age yrs, M/F]: Leukemia (4368, 27.8%, 5.4, 2519/1849); Lymphoma & other RES tumors (2996, 19.1%, 9.7, 2012/979, 1 hermaphrodite & 4 unknown); CNS [brain & spinal] (2089, 13.3%, 7.1, 1142/947); Symphatetic system (1243, 7.9%, 2.4, 650/593); Retinoblastoma (358, 2.3%, 1.4, 204/154); Renal (788, 5.0%, 3.3, 369/419); Liver (260, 1.7%, 1.8, 143/117); Malignant bone (1030, 6.6%, 12.6, 566/464); Soft tissue sarcomas (1052, 6.7%, 7.4, 611/441); Germ cell (971, 6.2%, 8.4, 346/622, 2 hermaphrodite, 1 unknown); Carcinoma & other malignant epithelial (462, 2.9%, 13.7, 226/236); Other/non-specific malignant (96, 0.5%, 7.8, 50/46). Five year survival rate was found as 70.8%. Conclusions: This registry has been used widely among health care professionals since its establishment in 2002. Survival rates for children and adolescents has been improved to 70%. This level of survival is at the acceptable level for an upper middle income country. This registry became a useful source for investigator and decision makers at national and international level.

scholarly journals Evaluation of Plasma Nucleosome Concentrations In Healthy Dogs And Dogs With A Variety of Common Cancers.

2021 ◽  
Author(s):  
Heather Wilson-Robles ◽  
Thomas Bygott ◽  
Theresa Kathleen Kelly ◽  
Tasha Miller ◽  
Pamela Miller ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Area Under The Curve ◽  
Soft Tissue Sarcomas ◽  
Tumor Biomarkers ◽  
Mast Cell Tumors ◽  
Free Dna ◽  
Healthy Dogs ◽  
Tumor Types ◽  
Apoptosis And Necrosis ◽  
Histone Core

Abstract Background: Cell free DNA, in the form of nucleosomes, is released into circulation during apoptosis and necrosis in a variety of diseases. They are small fragments of chromosomes that are composed of DNA wrapped around a histone core made of four duplicate histone proteins forming an octamer. The nucleosome compartment is a relatively uninvestigated area of circulating tumor biomarkers in dogs. The objectives of this study were to quantify and better characterize nucleosomes in 528 dogs with various common malignancies and 134 healthy dogs. Results: The sensitivity of elevated circulating nucleosome concentrations for the detection of cancer in all dogs was 49.8% with a specificity of 97% with an area under the curve of 68.74%. The top 4 malignancies detected by the test included lymphoma, hemangiosarcoma, histiocytic sarcoma and malignant melanoma. The malignancies least likely to be detected were soft tissue sarcomas and mast cell tumors. Conclusions: A variety of tumor types may cause elevated nucleosome concentations in dogs. Tumors of hematopoietic origin are most likely to cause elevations and local tumors such as soft tissue sarcomas are least likely to cause elevations in plasma nucleosome concentrations.

Reductions in margin length after excision of grade II mast cell tumors and grade I and II soft tissue sarcomas in dogs

2017 ◽  
Vol 47 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Milan Milovancev ◽  
Katy L. Townsend ◽  
Shay Bracha ◽  
Elena Gorman ◽  
Kaitlin Curran ◽  
...  
Keyword(s):  
Mast Cell ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Mast Cell Tumors ◽  
Grade Ii

scholarly journals Identification of common predisposing loci to hematopoietic cancers in four dog breeds

PLoS Genetics ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. e1009395 ◽  
Author(s):  
Benoît Hédan ◽  
Édouard Cadieu ◽  
Maud Rimbault ◽  
Amaury Vaysse ◽  
Caroline Dufaure de Citres ◽  
...  
Keyword(s):  
Mast Cell ◽  
Association Studies ◽  
Canine Model ◽  
Genome Wide Association Studies ◽  
Targeted Next Generation Sequencing ◽  
Mast Cell Tumors ◽  
Regulatory Variants ◽  
Mast Cell Tumor ◽  
Canine Cancer ◽  
Hematopoietic Cancers

Histiocytic sarcoma (HS) is a rare but aggressive cancer in both humans and dogs. The spontaneous canine model, which has clinical, epidemiological, and histological similarities with human HS and specific breed predispositions, provides a unique opportunity to unravel the genetic basis of this cancer. In this study, we aimed to identify germline risk factors associated with the development of HS in canine-predisposed breeds. We used a methodology that combined several genome-wide association studies in a multi-breed and multi-cancer approach as well as targeted next-generation sequencing, and imputation We combined several dog breeds (Bernese mountain dogs, Rottweilers, flat-coated retrievers, and golden retrievers), and three hematopoietic cancers (HS, lymphoma, and mast cell tumor). Results showed that we not only refined the previously identified HS risk CDKN2A locus, but also identified new loci on canine chromosomes 2, 5, 14, and 20. Capture and targeted sequencing of specific loci suggested the existence of regulatory variants in non-coding regions and methylation mechanisms linked to risk haplotypes, which lead to strong cancer predisposition in specific dog breeds. We also showed that these canine cancer predisposing loci appeared to be due to the additive effect of several risk haplotypes involved in other hematopoietic cancers such as lymphoma or mast cell tumors as well. This illustrates the pleiotropic nature of these canine cancer loci as observed in human oncology, thereby reinforcing the interest of predisposed dog breeds to study cancer initiation and progression.

Soft Tissue Sarcomas in the General Population Living near a Chemical Plant in Northern Italy

2000 ◽  
Vol 86 (5) ◽  
pp. 381-383 ◽  
Author(s):  
Gloria Costani ◽  
Paolo Rabitti ◽  
Adelmo Mambrini ◽  
Edoardo Bai ◽  
Franco Berrino
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Confidence Interval ◽  
Environmental Pollution ◽  
Cancer Registry ◽  
Soft Tissue Sarcomas ◽  
Industrial Area ◽  
Cancer Registries ◽  
Northern Italy ◽  
Toxic Emissions

Background and objectives After the notification by a general practitioner of a high frequency of soft tissue sarcomas among subjects living close to the industrial area of the city of Mantua (northern Italy), the local Medical Association carried out a formal epidemiologic investigation to corroborate or falsify the hypothesized excess. Several industrial activities of the area were hypothesized to be a source of environmental pollution that might cause soft tissue sarcomas. Methods All general practitioners working in the area were requested to report the cases of soft tissue sarcoma diagnosed in the study area. Person-years of observation were computed for all subjects who ever resided in the area between 1984 and 1997. Expected incidence was computed from the cancer registry covering a nearby province (Varese) and from the pool of Italian cancer registries. Peripheral soft tissue sarcoma and visceral sarcomas were included in the analysis. Results and conclusions Overall, 20 cases were observed in a 13-year period, 8.87 were expected from the Varese province cancer registry and 7.72 from the pool of Italian registries. The corresponding standardized morbidity ratios were 2.25 (95% confidence interval, 1.34–3.47) and 2.6 (95% confidence interval, 1.6–4.0), respectively. A significant excess persisted after excluding 5 cases that had been the object of the original notification. We hypothesize that the soft tissue sarcoma excess may have resulted from environmental pollution by industrial toxic emissions, which likely included 2,3,7,8-tetra-chloro-dibenzo-dioxin.

Long‐term outcomes of dogs undergoing surgical resection of mast cell tumors and soft tissue sarcomas: A prospective 2‐year‐long study

2019 ◽  
Vol 49 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Milan Milovancev ◽  
Katy L. Townsend ◽  
Joanne L. Tuohy ◽  
Elena Gorman ◽  
Shay Bracha ◽  
...  
Keyword(s):  
Mast Cell ◽  
Soft Tissue ◽  
Surgical Resection ◽  
Soft Tissue Sarcomas ◽  
Long Term Outcomes ◽  
Mast Cell Tumors

scholarly journals A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

2016 ◽  
Vol 45 (6) ◽  
pp. 715-722 ◽  
Author(s):  
Suzanne Bartholf DeWitt ◽  
William C. Eward ◽  
Cindy A. Eward ◽  
Alexander L. Lazarides ◽  
Melodi Javid Whitley ◽  
...  
Keyword(s):  
Mast Cell ◽  
Soft Tissue ◽  
Normal Tissue ◽  
Imaging System ◽  
Soft Tissue Sarcomas ◽  
Mast Cell Tumors

scholarly journals Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases

2021 ◽  
Vol 8 (7) ◽  
pp. 136
Author(s):  
Julia Maria Grassinger ◽  
Andreas Floren ◽  
Tobias Müller ◽  
Argiñe Cerezo-Echevarria ◽  
Christoph Beitzinger ◽  
...  
Keyword(s):  
Bone Tumors ◽  
Soft Tissue Sarcomas ◽  
Benign Tumors ◽  
Malignant Neoplasms ◽  
Routine Diagnostics ◽  
Mast Cell Tumors ◽  
Neoplastic Processes ◽  
Study Population ◽  
Tumor Like Lesions ◽  
Labrador Retrievers

Breed predispositions to canine digital neoplasms are well known. However, there is currently no statistical analysis identifying the least affected breeds. To this end, 2912 canine amputated digits submitted from 2014–2019 to the Laboklin GmbH & Co. KG for routine diagnostics were statistically analyzed. The study population consisted of 155 different breeds (most common: 634 Mongrels, 411 Schnauzers, 197 Labrador Retrievers, 93 Golden Retrievers). Non-neoplastic processes were present in 1246 (43%), tumor-like lesions in 138 (5%), and neoplasms in 1528 cases (52%). Benign tumors (n = 335) were characterized by 217 subungual keratoacanthomas, 36 histiocytomas, 35 plasmacytomas, 16 papillomas, 12 melanocytomas, 9 sebaceous gland tumors, 6 lipomas, and 4 bone tumors. Malignant neoplasms (n = 1193) included 758 squamous cell carcinomas (SCC), 196 malignant melanomas (MM), 76 soft tissue sarcomas, 52 mast cell tumors, 37 non-specified sarcomas, 29 anaplastic neoplasms, 24 carcinomas, 20 bone tumors, and 1 histiocytic sarcoma. Predisposed breeds for SCC included the Schnauzer (log OR = 2.61), Briard (log OR = 1.78), Rottweiler (log OR = 1.54), Poodle (log OR = 1.40), and Dachshund (log OR = 1.30). Jack Russell Terriers (log OR = −2.95) were significantly less affected by SCC than Mongrels. Acral MM were significantly more frequent in Rottweilers (log OR = 1.88) and Labrador Retrievers (log OR = 1.09). In contrast, Dachshunds (log OR = −2.17), Jack Russell Terriers (log OR = −1.88), and Rhodesian Ridgebacks (log OR = −1.88) were rarely affected. This contrasted with the well-known predisposition of Dachshunds and Rhodesian Ridgebacks to oral and cutaneous melanocytic neoplasms. Further studies are needed to explain the underlying reasons for breed predisposition or “resistance” to the development of specific acral tumors and/or other sites.

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