Predictors of Cardiovascular and Gastrointestinal Disorders, Inappropriate Nonsteroidal Anti-inflammatory Drug Use, and Alzheimer’s Disease and Related Dementia in Older Adults with Osteoarthritis

2020 ◽  
Author(s):  
Jayeshkumar Patel
2012 ◽  
Vol 8 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Sharlène Côté ◽  
Pierre-Hugues Carmichael ◽  
René Verreault ◽  
Joan Lindsay ◽  
Jean Lefebvre ◽  
...  

2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Agustín G Yip ◽  
◽  
Robert C Green ◽  
Matthew Huyck ◽  
L Adrienne Cupples ◽  
...  

2000 ◽  
Vol 21 ◽  
pp. 204 ◽  
Author(s):  
Bas A. In 't Veld ◽  
Annemieke Ruitenberg ◽  
Lenore J. Launer ◽  
Albert Hofman ◽  
Monique M.B. Breteler ◽  
...  

1998 ◽  
Vol 73 (10) ◽  
pp. 951-955 ◽  
Author(s):  
C. Mary Beard ◽  
Stephen C. Waring ◽  
Peter C. O'Brien ◽  
Leonard T. Kurland ◽  
Emre Kokmen

Author(s):  
Anthony C. Allison ◽  
Ramon Cacabelos ◽  
Valter R.M. Lombardi ◽  
Xoan A. Álvarez ◽  
Carmen Vigo

Author(s):  
Sanna Vallius ◽  
Heidi Taipale ◽  
Marjaana Koponen ◽  
Anna-Maija Tolppanen ◽  
Antti Tanskanen ◽  
...  

Abstract Purpose We investigated the drug use before and after transition to automated multi-dose dispensing (MDD) service among persons with Alzheimer’s disease (AD) and compared whether the changes were similar in persons without AD. Methods The register-based Finnish nationwide MEDALZ cohort includes 70,718 community-dwelling persons diagnosed with AD during 2005–2011. Each person who initiated MDD was matched in both groups with a comparison person without MDD by age, gender and for persons with AD, also time since AD diagnosis at the start of MDD. The study cohort included 15,604 persons with AD in MDD and 15,604 no-MDD, and 5224 persons without AD in MDD and 5224 no-MDD. Point prevalence of drug use was assessed every 3 months, from 1 year before to 2 years after the start of MDD and compared between persons in MDD to those who did not have MDD. Results MDD was started on average 2.9 (SD 2.1) years after AD diagnosis. At the start of MDD, the prevalence of drug use increased especially for antipsychotics, antidepressants, opioids, paracetamol and use of ≥ 10 drugs among persons with and without AD. Prevalence of benzodiazepine use (from 12% 12 months before to 17% at start of MDD), memantine (from 29 to 46%) and ≥ 3 psychotropics (from 3.2 to 6.0%) increased among persons with AD. Decreasing trend was observed for benzodiazepine-related drugs, urinary antispasmodics and non-steroidal anti-inflammatory drugs. Conclusion MDD seems to be initiated when use of psychotropics is initiated and the number of drugs increases.


2021 ◽  
pp. 1-13
Author(s):  
Maria Pisu ◽  
Roy C. Martin ◽  
Liang Shan ◽  
Giovanna Pilonieta ◽  
Richard E. Kennedy ◽  
...  

Background: Use of specialists and recommended drugs has beneficial effects for older adults living with Alzheimer’s disease and related dementia (ADRD). Gaps in care may exist for minorities, e.g., Blacks, and especially in the United States (U.S.) Deep South (DS), a poor U.S. region with rising ADRD cases and minority overrepresentation. Currently, we have little understanding of ADRD care utilization in diverse populations in this region and elsewhere in the U.S. (non-DS), and the factors that adversely impact it. Objective: To examine utilization of specialists and ADRD drugs (outcomes) in racial/ethnic groups of older adults with ADRD and the personal or context-level factors affecting these outcomes in DS and non-DS. Methods: We obtained outcomes and personal-level covariates from claims for 127,512 Medicare beneficiaries with ADRD in 2013–2015, and combined county-level data in exploratory factor analysis to define context-level covariates. Adjusted analyses tested significant association of outcomes with Black/White race and other factors in DS and non-DS. Results: Across racial/ethnic groups, 33%–43% in DS and 43%–50% in non-DS used specialists; 47%–55% in DS and 41%–48% in non-DS used ADRD drugs. In adjusted analyses, differences between Blacks and Whites were not significant. Vascular dementia, comorbidities, poverty, and context-level factor “Availability of Medical Resources” were associated with specialist use; Alzheimer’s disease and senile dementia, comorbidities, and specialist use were associated with drug use. In non-DS only, other individual, context-level covariates were associated with the outcomes. Conclusion: We did not observe significant gaps in ADRD care in DS and non-DS; however, research should further examine determinants of low specialist and drug use in these regions.


PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222505 ◽  
Author(s):  
Julián Benito-León ◽  
Israel Contador ◽  
Saturio Vega ◽  
Alberto Villarejo-Galende ◽  
Félix Bermejo-Pareja

Sign in / Sign up

Export Citation Format

Share Document