The role of ENOS polymorphism (C774T) in the progression of acute peritonitis and the formation of complications

In order to determine the role of ENOS (C774T) gene polymorphism in the progression of acute peritonitis and the formation of complications, a clinical and biochemical study of 40 patients with acute peritonitis was conducted. As a result of the study, it was proved that the early period of acute peritonitis is characterized by the development of endogenous intoxication, intensification of oxidative phenomena, hypercoagulation of the homeostasis system and inhibition of fibrinolysis, and in patients with acute peritonitis, carriers of the pathological TT genotype of the endothelial nitric oxide synthase gene, more pronounced deviations of homeostatic parameters are observed. Key words: acute peritonitis, genotype, DNA diagnostics, genetic testing of genotypes.

Download Full-text

Role of Intronic MicroRNA in The Regulation of Endothelial Nitric Oxide Synthase Expression and The Proliferation of Endothelial Cells*

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS ◽

10.3724/sp.j.1206.2009.00755 ◽

2010 ◽

Vol 37 (7) ◽

pp. 747-753 ◽

Cited By ~ 4

Author(s):

Li-Mei YAN ◽

Jian-Yong WU ◽

Xiao-Hua YU ◽

Jing-Ou XU ◽

He-Sheng OU

Keyword(s):

Nitric Oxide ◽

Endothelial Cells ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

Download Full-text

Endothelial nitric oxide synthase polymorphism and venous thromboembolism: A meta-analysis of 9 studies involving 3993 subjects

Phlebology The Journal of Venous Disease ◽

10.1177/02683555211016626 ◽

2021 ◽

pp. 026835552110166

Author(s):

Guangbin Huang ◽

Xuejun Deng ◽

Yanan Xu ◽

Pan Wang ◽

Tao Li ◽

...

Keyword(s):

Nitric Oxide ◽

Venous Thromboembolism ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Meta Analysis ◽

Enos Polymorphism ◽

The Difference ◽

Oxide Synthase ◽

Endothelial Nitric Oxide ◽

Intron 4

Background Endothelial nitric oxide synthase (eNOS) polymorphism may influence the risk of venous thromboembolism (VTE). However, data from published studies with low statistical power are inconclusive. The present meta-analysis aimed to assess the relationship between eNOS polymorphism and the risk of VTE. Method Case-control studies evaluating the association between the eNOS polymorphism and VTE were searched in PubMed, Embase, Web of Science, Google Scholar, Wanfang, Chinese National Knowledge Infrastructure (CNKI), the Chongqing VIP Chinese Science and Technology Periodical Database (VIP), and Chinese Biomedical Literature Database (CBM). Results A total of 1588 cases and 2405 controls from 9 studies were included in the analysis. The results showed that eNOS G894T polymorphism was related to VTE susceptibility and the difference was statistically significant [T vs G: OR = 1.41, 95% CI (1.13, 1.75), P = 0.002; TT + GG vs TG: OR = 0.71, 95% CI (0.60, 0.84), P = 0.000; TT + TG vs GG: OR = 1.45, 95% CI (1.23, 1.70), P = 0.000]. Additionally, eNOS Intron 4 VNTR polymorphism was related to VTE susceptibility and the difference was statistically significant [4b4b vs 4a4a + 4a4b: OR = 2.77, 95% CI (1.01, 7.61), P = 0.048]. Conclusion ENOS G894T and eNOS Intron 4 VNTR polymorphisms were associated with VTE susceptibility, especially in Asian populations. However, multicenter studies with larger samples should be conducted to further clarify this association and verify our findings.

Download Full-text