STUDY ON CLINICAL CHARACTERISTICS AND ECHOCARDIOGRAPHY DOPPLER OF PATENT DUCTUS ARTERISUS IN PREMATURE INFANTS AT PEDIATRIC DEPARTMENT OF HUE CENTRAL HOSPITAL

Background: Patent ductus arteriosus (PDA) is common in premature infants, specific in very low birth weight (VLBW) infants. Frequency of PDA is inversely related to gestational age. This is a cause that can lead to death because of complications, especially premature neonates. Objective: To define the rate and clinical features of the patent ductus arteriosus in premature infants. Describe the morphological and hemodynamic changes of the heart in premature infants with patent ductus arteriosus by echocardiography Doppler. Patients and methods: Included 159 premature infants are treated at the Pediatric Department of Hue Central Hospital from 5/2010 to 5/2011. All of them were performed clinical examination and echocardiography Doppler within 3 days after giving birth. Results: The patent ductus arteriosus detected by echocardiography in premature infants was 65.4%, especially extremely premature infants <28 weeks, birth weight <1000 grams. Clinical symptoms of patent ductus arteriosus in premature infants is rapidly breathing seen in 81.7%, cardiac hyperactivity in 70.2%, strong second heart sound in 61.5%, rapid heart frequency in 41.3% and heart murmur is the least common in 10.6% of cases. Ultrasound result showed that 100% was left-right shunt. 76% of infants have ductus arteriosus diameter ≥2.0 mm, average size of the ductus arteriosus was 2.16 ± 0.66 mm. Index LA/Ao, LVDd and LVDS of infants having the patent ductus arteriosus were higher than the infants having closed ductus arteriosus with p<0.05. Conclusion: Patent ductus arteriosus have very high rate in premature infant. Clinical diagnosis is often difficult because only 7% of cases having heart murmur. Index LA/Ao, systolic and diastolic left ventricular size of infants having the patent ductus arteriosus are higher than the infants having closed ductus arteriosus

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Bedside patent ductus arteriosus ligatıon in low-birth-weight premature infants

Ortadoğu Tıp Dergisi ◽

10.21601/ortadogutipdergisi.435510 ◽

2018 ◽

Vol 10 (3) ◽

pp. 312-316

Author(s):

Murat Koç

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Patent Ductus Arteriosus ◽

Premature Infants ◽

Ductus Arteriosus ◽

Patent Ductus

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Ligation of patent ductus arteriosus in very low birth weight premature infants

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2020.03.009 ◽

2020 ◽

Vol 61 (4) ◽

pp. 399-405

Author(s):

Hasan F. Othman ◽

Debra T. Linfield ◽

Mohamed A. Mohamed ◽

Hany Aly

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Patent Ductus Arteriosus ◽

Premature Infants ◽

Very Low Birth Weight ◽

Ductus Arteriosus ◽

Patent Ductus

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SAFETY AND QUALITY OF INTRAVENOUS LIPIDS FOR NEWBORNS: EFFECTS ON CRITICAL DISEASES AND METABOLIC DISORDERS (PART II)

Neonatology surgery and perinatal medicine ◽

10.24061/2413-4260.xi.4.42.2021.11 ◽

2021 ◽

Vol 11 (4(42)) ◽

pp. 68-74

Author(s):

I. Anikin ◽

V. Snisar

Keyword(s):

Birth Weight ◽

Patent Ductus Arteriosus ◽

Premature Infants ◽

Intraventricular Hemorrhage ◽

Metabolic Disorders ◽

Ductus Arteriosus ◽

Lipid Emulsions ◽

Intravenous Lipids ◽

Patent Ductus

Premature birth and its complications cause stress in newborns, which restrains their physical growth for several weeks after birth and is associated with chronic morbidity and neurological disability in the future. Preterm infants face such difficulties as respiratory distress, cardiovascular disease, gastrointestinal dysfunction and very low birth weight. Most complications in newborns are associated with oxidative stress that develops during the early period of growth. The formation of free radicals entails oxidative damage to many organs and systems of the body and is the main factor responsible for the development of typical diseases of preterm infants, such as bronchopulmonary dysplasia, patent ductus arteriosus, retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, and respiratory distress syndrome. Premature infants depend on adequate early parenteral nutrition, which not only guarantees they will survive but also ensures positive health outcomes later in life. Early use of intravenous lipids helps to prevent essential fatty acid deficiencies, provides energy and substrates for cell membrane synthesis, which are important for the growth and development of infants with very low and extremely low birth weight. This publication represents data on the effect of intravenous lipids on critical conditions and metabolic disorders in newborns. Literature sources are analyzed and the existing evidence of the possible influence of lipid emulsions on critical diseases in newborns is presented: intraventricular hemorrhage; necrotizing enterocolitis, patent ductus arteriosus and thrombocytopenia; glucose metabolism (hypo- and hyperglycemia); hyperbilirubinemia and chronic liver damage. The literature review is aimed at finding optimal strategies for the use of lipid emulsions in intensive care of newborns to improve the quality of care for premature infants. The purpose of this work is to analyze the results of published studies and systematize data on the feasibility and safety of lipid emulsions used in newborns with critical diseases of the perinatal period.

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Left ventricular efficiency after ligation of patent ductus arteriosus for premature infants

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2013.02.019 ◽

2013 ◽

Vol 146 (6) ◽

pp. 1353-1358 ◽

Cited By ~ 5

Author(s):

Hazumu Nagata ◽

Kenji Ihara ◽

Kenichiro Yamamura ◽

Yoshihisa Tanoue ◽

Yuichi Shiokawa ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Premature Infants ◽

Ductus Arteriosus ◽

Left Ventricular ◽

Ventricular Efficiency ◽

Patent Ductus

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Echocardiographic Characteristics of Premature Infants with Patent Ductus Arteriosus

PEDIATRICS ◽

10.1542/peds.72.6.864 ◽

1983 ◽

Vol 72 (6) ◽

pp. 864-871 ◽

Cited By ~ 1

Author(s):

Gregory L. Johnson ◽

Gerard L. Breart ◽

Michael H. Gewitz ◽

Joel I. Brenner ◽

Peter Lang ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Premature Infants ◽

Aortic Root ◽

Ductus Arteriosus ◽

Left Ventricular ◽

Time Interval ◽

Systolic Time Interval ◽

Systolic Time ◽

Interval Ratio ◽

Patent Ductus

As part of a multicenter collaborative study, M-mode echocardiograms were obtained shortly after birth on 3,559 premature infants with birth weight ≤1,750 g. Of these infants, 1,496 did not develop a cardiac murmur or other signs of a "hemodynamically significant" patent ductus arteriosus (PDA). Echocardiographic parameters from this "normal" group were compared with results obtained from 415 infants in whom PDA was diagnosed on the basis of clinical findings alone, irrespective of the echocardiogram (PDA group). The best discrimination between the two groups, when considering a single parameter, was provided by a left atrial to aortic root ratio (LA/AO) of 1.40, a left ventricular to aortic root ratio (LV/AO) of 2.10, or a left ventricular systolic time interval ratio (LPEP/LVET) of 0.27. Multivariate analysis demonstrated that better separation between the two groups occurred when the left atrial to aortic root ratio and the left ventricular systolic time interval ratio were considered jointly. Because of a large degree of overlap of all echocardiographic variables between the normal group and the group with PDA, the echocardiogram alone was not a good indicator of PDA. However, when used in conjunction with a priori estimates of the probability of PDA (based, for example, on birth weight and degree of respiratory disease), use of echocardiographic data was found to improve the detection of hemodynamically significant patent ductus arteriosus in premature infants.

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