Echocardiographic Characteristics of Premature Infants with Patent Ductus Arteriosus

PEDIATRICS ◽  
1983 ◽  
Vol 72 (6) ◽  
pp. 864-871 ◽  
Author(s):  
Gregory L. Johnson ◽  
Gerard L. Breart ◽  
Michael H. Gewitz ◽  
Joel I. Brenner ◽  
Peter Lang ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Aortic Root ◽  
Ductus Arteriosus ◽  
Left Ventricular ◽  
Time Interval ◽  
Systolic Time Interval ◽  
Systolic Time ◽  
Interval Ratio ◽  
Patent Ductus

As part of a multicenter collaborative study, M-mode echocardiograms were obtained shortly after birth on 3,559 premature infants with birth weight ≤1,750 g. Of these infants, 1,496 did not develop a cardiac murmur or other signs of a "hemodynamically significant" patent ductus arteriosus (PDA). Echocardiographic parameters from this "normal" group were compared with results obtained from 415 infants in whom PDA was diagnosed on the basis of clinical findings alone, irrespective of the echocardiogram (PDA group). The best discrimination between the two groups, when considering a single parameter, was provided by a left atrial to aortic root ratio (LA/AO) of 1.40, a left ventricular to aortic root ratio (LV/AO) of 2.10, or a left ventricular systolic time interval ratio (LPEP/LVET) of 0.27. Multivariate analysis demonstrated that better separation between the two groups occurred when the left atrial to aortic root ratio and the left ventricular systolic time interval ratio were considered jointly. Because of a large degree of overlap of all echocardiographic variables between the normal group and the group with PDA, the echocardiogram alone was not a good indicator of PDA. However, when used in conjunction with a priori estimates of the probability of PDA (based, for example, on birth weight and degree of respiratory disease), use of echocardiographic data was found to improve the detection of hemodynamically significant patent ductus arteriosus in premature infants.

Value of Systolic Time Intervals in the Diagnosis of Large Patent Ductus Arteriosus in Fluid-Restricted and Mechanically Ventilated Preterm Infants

PEDIATRICS ◽  
1984 ◽  
Vol 74 (6) ◽  
pp. 1069-1074
Author(s):  
François Heitz ◽  
Jean-Claude Fouron ◽  
Nicolaas H. van Doesburg ◽  
Harry Bard ◽  
François Teasdale ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Right Ventricular ◽  
Ductus Arteriosus ◽  
Systolic Time Intervals ◽  
Left Ventricular ◽  
Ejection Time ◽  
Time Intervals ◽  
Systolic Time ◽  
Ventricular Ejection Time ◽  
Patent Ductus

M-mode echocardiographic features suggesting a patent ductus arteriosus are based on two groups of indirect criteria: dilation of the left cardiac cavities and changes of systolic time intervals. The reliability of the first group of criteria has been questioned in fluidlimited, mechanically ventilated preterm infants. The sensitivity of the systolic time intervals in the same circumstances is investigated. Twenty-three patients with a large patent ductus arteriosus were selected. Review of their echocardiograms shows that the sensitivity of the various criteria (expressed as percentage of positivity) was as follows: inversion of the ratio of left ventricular preejection period to right ventricular preejection period, 91.3%; left ventricular preejection period to left ventricular ejection time over right ventricular preejection period to right ventricular ejection time < 1, 83%; left atrium dilation, 74%; shortening of left ventricular preejection period, 70%; dilation of left ventricular internal dimensions in diastole, 65%; increase in left atrium/aorta, 52%; and decrease of left ventricular preejection period to left ventricular ejection time, 48%. Three criteria involving time intervals (left ventricular preejection period to right ventricular preejection period, left ventricular preejection period, and left ventricular preejection period to left ventricular ejection time) had 100% specificity. The lowest specificity was found with criteria involving the left atrium (left atrial to aortic root ratio 75% and left atrium 63%). It is concluded that study of systolic time intervals is a reliable means of detecting preterm infants with hemodynamically significant left-to-right shunt through a patent ductus arteriosus even if the infants are mechanically ventilated and fluid restricted.

scholarly journals Left ventricular efficiency after ligation of patent ductus arteriosus for premature infants

2013 ◽  
Vol 146 (6) ◽  
pp. 1353-1358 ◽  
Author(s):  
Hazumu Nagata ◽  
Kenji Ihara ◽  
Kenichiro Yamamura ◽  
Yoshihisa Tanoue ◽  
Yuichi Shiokawa ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Left Ventricular ◽  
Ventricular Efficiency ◽  
Patent Ductus

Effect of patent ductus arteriosus on left ventricular output in premature infants

1983 ◽  
Vol 102 (5) ◽  
pp. 754-757 ◽  
Author(s):  
Dale C. Alverson ◽  
Marlowe W. Eldridge ◽  
John D. Johnson ◽  
Rochelle Burstein ◽  
LuAnn Papile ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Left Ventricular ◽  
Left Ventricular Output ◽  
Patent Ductus

Echocardiographic systolic time intervals in premature infants with patent ductus arteriosus

1980 ◽  
Vol 1 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Gregory L. Johnson ◽  
Nirmala S. Desai ◽  
Carol M. Cottrill ◽  
Marianne Johnson ◽  
Jacqueline A. Noonan
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Systolic Time Intervals ◽  
Time Intervals ◽  
Systolic Time ◽  
Patent Ductus

scholarly journals Exploring the NT-proBNP expression in Premature Infants with Patent Ductus Arteriosus (PDA) by Echocardiography

2021 ◽  
Vol 37 (6-WIT) ◽  
Author(s):  
Yunlong Shi ◽  
Jianwei Ji ◽  
Chunying Wang
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
General Information ◽  
Left Ventricular ◽  
Expression Level ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Specificity And Sensitivity ◽  
Patent Ductus

Objectives: To investigate the correlation between echocardiographic indicators and the expression level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in premature infants (PIs) with patent ductus arteriosus (PDA) and the value of NT-proBNP in diagnosing symptomatic PDA (sPDA) in PIs whose gestational age (GA) was less than 32 weeks. Methods: Ninty premature infants were selected as the research objects, including 52 in the non-PDA group and 38 in the PDA group (26 sPDA cases and 12 cases with asymptomatic PDA (asPDA)) from February 2019 to March 2020. The general information of these infants was recorded, including gender, delivery method, maternal infection, and serum NT-proBNP level on the 3rd day after birth. They were screened by echocardiographic indicators under an artificial intelligence convolutional neural network (AI-CNN). The Receiver Operating Characteristic (ROC) curves were illustrated to decide serum NT-proBNP expression levels, thereby determining specificity and sensitivity of sPDA and the correlation between serum sPDA NT-proBNP expression and echocardiographic indicators. Results: The expression level of serum NT-proBNP in the sPDA group was greater than that in the asPDA group and the non-PDA group (P<0.001). The serum NT-proBNP expression level was positively correlated with the diameter of the ductus arteriosus in the sPDA group (r=0.462, P<0.001); it was also positively correlated with the ratio of left atrium/aorta (LA/AO) (r=0.573, P<0.001), but was not correlated with left ventricular ejection fraction (LVEF) (r=-0.015, P=0.747). Conclusion: The combination of serum NT-proBNP expression and echocardiography had clinical values in early diagnosis of PDA. doi: https://doi.org/10.12669/pjms.37.6-WIT.4853 How to cite this:Shi Y, Ji J, Wang C. Exploring the NT-proBNP expression in Premature Infants with Patent Ductus Arteriosus (PDA) by Echocardiography. Pak J Med Sci. 2021;37(6):1615-1619. doi: https://doi.org/10.12669/pjms.37.6-WIT.4853 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

STUDY ON CLINICAL CHARACTERISTICS AND ECHOCARDIOGRAPHY DOPPLER OF PATENT DUCTUS ARTERISUS IN PREMATURE INFANTS AT PEDIATRIC DEPARTMENT OF HUE CENTRAL HOSPITAL

2011 ◽  
pp. 30-35
Author(s):  
Thi Le Huynh ◽  
Hung Viet Phan ◽  
Huu Hoa Pham
Keyword(s):  
Birth Weight ◽  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Left Ventricular ◽  
Heart Murmur ◽  
Central Hospital ◽  
Pediatric Department ◽  
Echocardiography Doppler ◽  
Patent Ductus

Background: Patent ductus arteriosus (PDA) is common in premature infants, specific in very low birth weight (VLBW) infants. Frequency of PDA is inversely related to gestational age. This is a cause that can lead to death because of complications, especially premature neonates. Objective: To define the rate and clinical features of the patent ductus arteriosus in premature infants. Describe the morphological and hemodynamic changes of the heart in premature infants with patent ductus arteriosus by echocardiography Doppler. Patients and methods: Included 159 premature infants are treated at the Pediatric Department of Hue Central Hospital from 5/2010 to 5/2011. All of them were performed clinical examination and echocardiography Doppler within 3 days after giving birth. Results: The patent ductus arteriosus detected by echocardiography in premature infants was 65.4%, especially extremely premature infants <28 weeks, birth weight <1000 grams. Clinical symptoms of patent ductus arteriosus in premature infants is rapidly breathing seen in 81.7%, cardiac hyperactivity in 70.2%, strong second heart sound in 61.5%, rapid heart frequency in 41.3% and heart murmur is the least common in 10.6% of cases. Ultrasound result showed that 100% was left-right shunt. 76% of infants have ductus arteriosus diameter ≥2.0 mm, average size of the ductus arteriosus was 2.16 ± 0.66 mm. Index LA/Ao, LVDd and LVDS of infants having the patent ductus arteriosus were higher than the infants having closed ductus arteriosus with p<0.05. Conclusion: Patent ductus arteriosus have very high rate in premature infant. Clinical diagnosis is often difficult because only 7% of cases having heart murmur. Index LA/Ao, systolic and diastolic left ventricular size of infants having the patent ductus arteriosus are higher than the infants having closed ductus arteriosus

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