Faculty Opinions recommendation of Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.

2002 ◽  
Author(s):  
Ben Shen
Keyword(s):  
Amino Acid ◽  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotic

scholarly journals Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

2017 ◽  
Vol 8 (9) ◽  
pp. 5992-6004 ◽  
Author(s):  
Tiia Kittilä ◽  
Claudia Kittel ◽  
Julien Tailhades ◽  
Diane Butz ◽  
Melanie Schoppet ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Synthesis ◽  
Acid Level ◽  
Amino Acid Level ◽  
Antibiotic Biosynthesis ◽  
Carrier Protein ◽  
Glycopeptide Antibiotics ◽  
Glycopeptide Antibiotic ◽  
Protein Substrates

Halogenase enzymes involved in glycopeptide antibiotic biosynthesis accept aminoacyl-carrier protein substrates.

scholarly journals A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis

2018 ◽  
Vol 54 (17) ◽  
pp. 2146-2149 ◽  
Author(s):  
Julien Tailhades ◽  
Melanie Schoppet ◽  
Anja Greule ◽  
Madeleine Peschke ◽  
Clara Brieke ◽  
...  
Keyword(s):  
Amino Acid ◽  
Building Blocks ◽  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotic ◽  
Peptide Thioesters ◽  
Non Ribosomal Peptides

Non-ribosomal peptides contain an array of amino acid building blocks that can present challenges for the synthesis of important intermediates. Here we report a route to incorporate phenylglycine residues in peptide thioesters without significant racemisation.

Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis

2005 ◽  
Vol 274 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Stefano Donadio ◽  
Margherita Sosio ◽  
Evi Stegmann ◽  
Tilmann Weber ◽  
Wolfgang Wohlleben
Keyword(s):  
Comparative Analysis ◽  
Gene Clusters ◽  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotic

scholarly journals The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

2019 ◽  
Vol 14 (12) ◽  
pp. 2932-2941 ◽  
Author(s):  
Milda Kaniusaite ◽  
Robert J. A. Goode ◽  
Ralf B. Schittenhelm ◽  
Thomas M. Makris ◽  
Max J. Cryle
Keyword(s):  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotic

scholarly journals The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones

2017 ◽  
Vol 13 (1) ◽  
pp. 110-120 ◽  
Author(s):  
Madeleine Peschke ◽  
Clara Brieke ◽  
Michael Heimes ◽  
Max J. Cryle
Keyword(s):  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotic

scholarly journals A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

2010 ◽  
Vol 107 (35) ◽  
pp. 15391-15396 ◽  
Author(s):  
T. M. Makris ◽  
M. Chakrabarti ◽  
E. Munck ◽  
J. D. Lipscomb
Keyword(s):  
Amino Acid ◽  
Antibiotic Biosynthesis

Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis

MedChemComm ◽  
2016 ◽  
Vol 7 (1) ◽  
pp. 132-140
Author(s):  
Clara Brieke ◽  
Theresa Maier ◽  
Martin Schröter ◽  
Max J. Cryle
Keyword(s):  
Bacterial Infections ◽  
Cytochrome P450s ◽  
Peptide Inhibitor ◽  
Antibiotic Biosynthesis ◽  
Glycopeptide Antibiotics ◽  
Glycopeptide Antibiotic ◽  
Gram Positive ◽  
Design And Synthesis

The glycopeptide antibiotics are important clinical antibiotics that are currently employed against serious Gram-positive bacterial infections.

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