Faculty Opinions recommendation of Transcription factor IIB acetylates itself to regulate transcription.

2003 ◽  
Author(s):  
Andrew D Sharrocks
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Iib

scholarly journals In vitro fluorescence studies of transcription factor IIB-DNA interaction

2015 ◽  
Vol 62 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Andrzej Górecki ◽  
Małgorzata Figiel ◽  
Marta Dziedzicka-Wasylewska
Keyword(s):  
Transcription Factor ◽  
Dna Interaction ◽  
Fluorescence Studies ◽  
Transcription Factor Iib

Interaction of the TFIIB zinc ribbon with RNA polymerase II

2008 ◽  
Vol 36 (4) ◽  
pp. 595-598 ◽  
Author(s):  
Laura M. Elsby ◽  
Stefan G.E. Roberts
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Structural Models ◽  
Initiation Complex ◽  
General Transcription Factors ◽  
Transcription Factor Iib ◽  
General Transcription Factor ◽  
Zinc Ribbon

Transcription by RNA polymerase II requires the assembly of the general transcription factors at the promoter to form a pre-initiation complex. The general transcription factor TF (transcription factor) IIB plays a central role in the assembly of the pre-initiation complex, providing a bridge between promoter-bound TFIID and RNA polymerase II/TFIIF. We have characterized a series of TFIIB mutants in their ability to support transcription and recruit RNA polymerase II to the promoter. Our analyses identify several residues within the TFIIB zinc ribbon that are required for RNA polymerase II assembly. Using the structural models of TFIIB, we describe the interface between the TFIIB zinc ribbon region and RNA polymerase II.

Transcription factor IIB acetylates itself to regulate transcription

Nature ◽  
2003 ◽  
Vol 424 (6951) ◽  
pp. 965-969 ◽  
Author(s):  
Chu H. Choi ◽  
Makoto Hiromura ◽  
Anny Usheva
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Iib

Core promoter elements recognized by transcription factor IIB

2006 ◽  
Vol 34 (6) ◽  
pp. 1051-1053 ◽  
Author(s):  
W. Deng ◽  
S.G.E. Roberts
Keyword(s):  
Transcription Factor ◽  
Rna Polymerase Ii ◽  
Core Promoter ◽  
Critical Role ◽  
Tata Box ◽  
Transcription Factor Iib ◽  
General Transcription Factor ◽  
Recognition Elements ◽  
Recognition Motifs ◽  
Definition Of

The general transcription factor TFIIB (transcription factor IIB) plays a critical role in the assembly of the RNA polymerase II pre-initiation complex. TFIIB can make sequence-specific DNA contacts both upstream and downstream of the TATA box. This has led to the definition of two core promoter BREs (TFIIB-recognition elements), one upstream [BREu (upstream BRE)] and one downstream of TATA box [BREd (downstream BRE)]. TFIIB–BREu and TFIIB–BREd contacts are mediated by two independent DNA-recognition motifs within the core domain of TFIIB. Both the BREu and the BREd modulate the transcriptional potency of a promoter. However, the net effect of the BREs on promoter activity is dependent on the specific blend of elements present within a core promoter.

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