Faculty Opinions recommendation of Toward the prevention of acute lung injury: protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion.

2007 ◽  
Author(s):  
Greg Martin
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Large Tidal Volume ◽  
Volume Ventilation

Toward the prevention of acute lung injury: Protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion*

2007 ◽  
Vol 35 (7) ◽  
pp. 1660-1666 ◽  
Author(s):  
Murat Yilmaz ◽  
Mark T. Keegan ◽  
Remzi Iscimen ◽  
Bekele Afessa ◽  
Curtis F. Buck ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Large Tidal Volume ◽  
Volume Ventilation

Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits

2004 ◽  
Vol 286 (6) ◽  
pp. L1114-L1121 ◽  
Author(s):  
Kiyoshi Moriyama ◽  
Akitoshi Ishizaka ◽  
Morio Nakamura ◽  
Hiroshi Kubo ◽  
Toru Kotani ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Mechanical Stress ◽  
Clinical Outcomes ◽  
Alveolar Macrophages ◽  
Fold Increase ◽  
Large Tidal Volume ◽  
Tnf Α ◽  
Cd14 Mrna

Ventilation with a small tidal volume (Vt) is associated with better clinical outcomes than with a large Vt, particularly in critical settings, including acute lung injury. To determine whether Vt influences the lipopolysaccaharide (LPS) recognition pathway, we studied CD14 expression in rabbit lungs and the release of TNF-α by cultured alveolar macrophages after 240 min of ventilation with a large (20 ml/kg) vs. a small (5 ml/kg) Vt. We also applied small or large Vt to lungs instilled with 50 μg/kg of LPS. The alveolar macrophages collected after large Vt ventilation revealed a 20-fold increase in LPS-induced TNF-α release compared with those collected after small Vt ventilation, whereas TNF-α was undetectable without LPS stimulation. In animals ventilated with a large Vt, the expression of CD14 mRNA in whole lung homogenates and the expression of CD14 protein on alveolar macrophages, assessed by immunohistochemistry, were both significantly increased in the absence of LPS stimulation. A large Vt applied to LPS-instilled lungs increased the pulmonary albumin permeability and TNF-α release into the plasma. These results suggest that mechanical stress caused by a large Vt sensitizes the lungs to endotoxin, a phenomenon that may occur partially via the upregulation of CD14.

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