Faculty Opinions recommendation of Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii.

2007 ◽  
Author(s):  
Matthew Bogyo
Keyword(s):  
Toxoplasma Gondii ◽  
Proteomic Analysis ◽  
Host Parasite Interactions ◽  
Host Parasite

scholarly journals Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection

2017 ◽  
Author(s):  
Ellen Tedford ◽  
Glenn McConkey
Keyword(s):  
Toxoplasma Gondii ◽  
Neurological Diseases ◽  
Behavioral Changes ◽  
Cns Infection ◽  
Parasite Transmission ◽  
Hormonal Responses ◽  
Host Parasite Interactions ◽  
Host Parasite ◽  
Neurological Infection ◽  
Host Brain

Although the parasite Toxoplasma gondii is one of the most pervasive neurotropic pathogens in the world, the host-parasite interactions during CNS infection and consequences of neurological infection are just beginning to be unraveled. The chronic stages of infection have been considered dormant, although several studies have found correlations of infection with an array of host behavioral changes. These may facilitate parasite transmission and impact neurological diseases. During infection, in addition to the presence of the parasites within neurons, host-mediated neuroimmune and hormonal responses to infection are also present. T. gondii induces numerous changes to host neurons during infection and globally alters host neurological signaling pathways, as discussed in this review. Understanding the neurophysiological changes in the host brain is imperative to understanding the parasitic mechanisms and to delineate the effects of this single-celled parasite on health and its contribution to neurological disease.

scholarly journals Proteomic Analysis of Rhoptry Organelles Reveals Many Novel Constituents for Host-Parasite Interactions inToxoplasma gondii

2005 ◽  
Vol 280 (40) ◽  
pp. 34245-34258 ◽  
Author(s):  
Peter J. Bradley ◽  
Chris Ward ◽  
Stephen J. Cheng ◽  
David L. Alexander ◽  
Susan Coller ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Host Parasite Interactions ◽  
Host Parasite

scholarly journals Divergent co-transcriptomes of different host cells infected with Toxoplasma gondii reveal cell type-specific host-parasite interactions

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Izabela J. Swierzy ◽  
Ulrike Händel ◽  
Alexander Kaever ◽  
Michael Jarek ◽  
Maren Scharfe ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Host Cells ◽  
Cell Type ◽  
Specific Host ◽  
Host Parasite Interactions ◽  
Cell Type Specific ◽  
Host Parasite

Proteomic analysis of Strongyloides stercoralis L3 larvae

Parasitology ◽  
2010 ◽  
Vol 137 (10) ◽  
pp. 1577-1583 ◽  
Author(s):  
A. MARCILLA ◽  
J. SOTILLO ◽  
A. PÉREZ-GARCIA ◽  
R. IGUAL-ADELL ◽  
M. LUZ VALERO ◽  
...  
Keyword(s):  
Developing Countries ◽  
Proteomic Analysis ◽  
Strongyloides Stercoralis ◽  
Diagnostic Tools ◽  
Chronic Infections ◽  
Neglected Disease ◽  
Human Host ◽  
Host Parasite Interactions ◽  
Associated Proteins ◽  
Host Parasite

SUMMARYStrongyloidiasis can be perpetuated by autoinfection with the filariform larvae L3, causing asymptomatic chronic infections and creating a population of carriers, affecting not only developing countries. So far, very little is known about the proteins that interact with the human host, and few proteins from the infective Strongyloides stercoralis L3 have been characterized. Here, we report results obtained from a proteomic analysis of the proteins from S. stercoralis L3 larvae obtained from patients. Since the genome of S. stercoralis is not yet available, we used proteomic analysis to identify 26 different proteins, 13 of them released by short digestion with trypsin, which could represent surface-associated proteins. The present work extends our knowledge of host-parasite interactions by identifying proteins that could be of interest in the development of diagnostic tools, vaccines, or treatments for a neglected disease like strongyloidiasis.

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