Faculty Opinions recommendation of Mechanistic analysis of chemical permeation enhancers for oral drug delivery.

Author(s):  
Amnon Hoffman
Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 339 ◽  
Author(s):  
Maher ◽  
Casettari ◽  
Illum

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.


2020 ◽  
Vol 30 (45) ◽  
pp. 2004257
Author(s):  
Qin M. Qi ◽  
Miya Duffy ◽  
Alex M. Curreri ◽  
Joel P. R. Balkaran ◽  
Eden E. L. Tanner ◽  
...  

2008 ◽  
Vol 128 (2) ◽  
pp. 128-133 ◽  
Author(s):  
Kathryn Whitehead ◽  
Natalie Karr ◽  
Samir Mitragotri

2014 ◽  
Vol 9 (2) ◽  
pp. 51-64 ◽  
Author(s):  
Yang Chen ◽  
Peng Quan ◽  
Xiaochang Liu ◽  
Manli Wang ◽  
Liang Fang

Author(s):  
. Shivani ◽  
Ritika Puri

Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.


2020 ◽  
Vol 26 (36) ◽  
pp. 4601-4614
Author(s):  
Taha Umair Wani ◽  
Roohi Mohi-ud-Din ◽  
Asmat Majeed ◽  
Shabnam Kawoosa ◽  
Faheem Hyder Pottoo

Transdermal route has been an ever sought-after means of drug administration, regarded as being the most convenient and patient compliant. However, skin poses a great barrier to the entry of the external particles including bacteria, viruses, allergens, and drugs as well (mostly hydrophilic or high molecular weight drugs), consequent to its complex structure and composition. Among the various means of enhancing drug permeation through the skin, e.g. chemical permeation enhancers, electroporation, thermophoresis, etc. drug delivery through nanoparticles has been of great interest. Current literature reports a vast number of nanoparticles that have been implicated for drug delivery through the skin. However, a precise account of critical factors involved in drug delivery and mechanisms concerning the permeation of nanoparticles through the skin is necessary. The purpose of this review is to enumerate the factors crucial in governing the prospect of drug delivery through skin and classify the skin permeation mechanisms of nanoparticles. Among the various mechanisms discussed are the ones governed by principles of kinetics, osmotic gradient, adhesion, hydration, diffusion, occlusion, electrostatic interaction, thermodynamics, etc. Among the most common factors affecting skin permeation of nanoparticles that are discussed include size, shape, surface charge density, composition of nanoparticles, mechanical stress, pH, etc.


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