scholarly journals A Review on Chemical Permeation Enhancers used in the Formulation of Transdermal Drug Delivery System

2021 ◽  
pp. 429-437
Author(s):  
. Shivani ◽  
Ritika Puri
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Free Water ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Penetration Enhancers ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.

Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery

2020 ◽  
Vol 30 (45) ◽  
pp. 2004257
Author(s):  
Qin M. Qi ◽  
Miya Duffy ◽  
Alex M. Curreri ◽  
Joel P. R. Balkaran ◽  
Eden E. L. Tanner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

scholarly journals Novel chemical permeation enhancers for transdermal drug delivery

2014 ◽  
Vol 9 (2) ◽  
pp. 51-64 ◽  
Author(s):  
Yang Chen ◽  
Peng Quan ◽  
Xiaochang Liu ◽  
Manli Wang ◽  
Liang Fang
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

scholarly journals Design, Synthesis of Novel Lipids as Chemical Permeation Enhancers and Development of Nanoparticle System for Transdermal Drug Delivery

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82581 ◽  
Author(s):  
Srujan Marepally ◽  
Cedar H. A. Boakye ◽  
Punit P. Shah ◽  
Jagan Reddy Etukala ◽  
Adithi Vemuri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Permeation Enhancers ◽  
Design Synthesis ◽  
Chemical Permeation Enhancers ◽  
Nanoparticle System ◽  
Chemical Permeation

scholarly journals Transmucosal Absorption Enhancers in the Drug Delivery Field

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 339 ◽  
Author(s):  
Maher ◽  
Casettari ◽  
Illum
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Permeation Enhancer ◽  
Special Issue ◽  
Permeation Enhancers ◽  
Absorption Enhancers ◽  
Chemical Permeation Enhancers ◽  
Epithelial Barriers ◽  
Chemical Permeation

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.

scholarly journals Microneedle Array Patches: Characterization and in -vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 66-75
Author(s):  
Zainab A. Sadeq
Keyword(s):  
Drug Delivery ◽  
Blood Vessel ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Solid Polymer ◽  
Microneedle Array ◽  
Microneedle Patch ◽  
Novel Drug

 Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle.  Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

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