Faculty Opinions recommendation of CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.

Author(s):  
Joyce Popoola
2019 ◽  
Vol 8 (8) ◽  
pp. 1147 ◽  
Author(s):  
Lemerle ◽  
Garnier ◽  
Planchais ◽  
Brilland ◽  
Subra ◽  
...  

Predictive biomarkers of acute rejection (AR) are lacking. Pre-transplant expression of CD45RC on blood CD8+ T cells has been shown to predict AR in kidney transplant (KT) patients. The objective of the present study was to study CD45RC expression in a large cohort of KT recipients exposed to modern immunosuppressive regimens. CD45RC expression on T cells was analyzed in 128 KT patients, where 31 patients developed AR, of which 24 were found to be T-cell mediated (TCMR). Pre-transplant CD4+ and CD8+ CR45RChigh T cell proportions were significantly higher in patients with AR. The frequency of CD45RChigh T cells was significantly associated with age at transplantation but was not significantly different according to gender, history of transplantation, pre-transplant immunization, and de novo donor specific anti-Human Leucocyte Antigen (HLA) antibody. Survival-free AR was significantly better in patients with CD8+ CD45RChigh T cells below 58.4% (p = 0.0005), but not different according to CD4+ T cells (p = 0.073). According to multivariate analysis, CD8+ CD45RChigh T cells above 58.4% increased the risk of AR 4-fold (HR 3.96, p = 0.003). Thus, pre-transplant CD45RC expression on CD8+ T cells predicted AR, mainly TCMR, in KT patients under modern immunosuppressive therapies. We suggest that CD45RC expression should be evaluated in a prospective study to validate its usefulness to quantify the pre-transplant risk of AR.


2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Fleur S. Peters ◽  
Annemiek M. A. Peeters ◽  
Pooja R. Mandaviya ◽  
Joyce B. J. van Meurs ◽  
Leo J. Hofland ◽  
...  

2014 ◽  
Vol 29 (8) ◽  
pp. 1587-1597 ◽  
Author(s):  
A. P. Bouvy ◽  
M. Klepper ◽  
M. M. L. Kho ◽  
K. Boer ◽  
M. G. H. Betjes ◽  
...  

2010 ◽  
Vol 89 (3) ◽  
pp. 366-368 ◽  
Author(s):  
Farida Abadja ◽  
Eric Alamartine ◽  
François Berthoux ◽  
Christophe Mariat ◽  
Christian Genin ◽  
...  

2018 ◽  
Vol 102 ◽  
pp. S144
Author(s):  
Gloria Queipo ◽  
Marco Antonio Carmona ◽  
Luis-Antonio García Mosqueda ◽  
Luis García-Covarrubias ◽  
Miguel Angel Fonseca-Sánchez ◽  
...  

2018 ◽  
Vol 102 ◽  
pp. S183
Author(s):  
Fleur S Peters ◽  
Annemiek M Peeters ◽  
Pooja R Mandaviya ◽  
Joyce B van Meurs ◽  
Leo J Hofland ◽  
...  

2009 ◽  
Vol 24 (5) ◽  
pp. 1635-1644 ◽  
Author(s):  
V. D. K. D. Sewgobind ◽  
M. M. L. Kho ◽  
L. J. W. van der Laan ◽  
T. K. Hendrikx ◽  
T. van Dam ◽  
...  

2007 ◽  
Vol 18 (2) ◽  
pp. 159-165 ◽  
Author(s):  
J.H.L. Velthuis ◽  
D.A. Hesselink ◽  
T.K. Hendrikx ◽  
B.J. van der Mast ◽  
M. Klepper ◽  
...  

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