Faculty Opinions recommendation of MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.

2011 ◽  
Author(s):  
Andrew Fry
Keyword(s):  
Safety Mechanism ◽  
Spindle Position

MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

2011 ◽  
Vol 13 (9) ◽  
pp. 1040-1050 ◽  
Author(s):  
Catarina P. Samora ◽  
Binyam Mogessie ◽  
Leslie Conway ◽  
Jennifer L. Ross ◽  
Anne Straube ◽  
...  
Keyword(s):  
Safety Mechanism ◽  
Spindle Position

scholarly journals Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1441
Author(s):  
En-Ju Chou ◽  
Tang K. Tang
Keyword(s):  
Brain Size ◽  
Neurodevelopmental Disorder ◽  
Mitotic Progression ◽  
Centriole Duplication ◽  
Spindle Poles ◽  
Multipolar Spindles ◽  
Mitotic Abnormalities ◽  
Cortical Localization ◽  
Spindle Position ◽  
Autosomal Recessive Primary Microcephaly

Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain size with mild to moderate intellectual disability. We previously demonstrated that human microcephaly RTTN played an important role in regulating centriole duplication during interphase, but the role of RTTN in mitosis is not fully understood. Here, we show that RTTN is required for normal mitotic progression and correct spindle position. The depletion of RTTN induces the dispersion of the pericentriolar protein γ-tubulin and multiple mitotic abnormalities, including monopolar, abnormal bipolar, and multipolar spindles. Importantly, the loss of RTTN altered NuMA/p150Glued congression to the spindle poles, perturbed NuMA cortical localization, and reduced the number and the length of astral microtubules. Together, our results provide a new insight into how RTTN functions in mitosis.

A Static Game Study between Food Enterprises Based on Value Perception Differences of Food Quality and Safety

2013 ◽  
Vol 791-793 ◽  
pp. 2171-2174
Author(s):  
Yuan Fen Yin ◽  
Yun Deng ◽  
Xiu Li Sang
Keyword(s):  
Food Quality ◽  
Game Model ◽  
Quality And Safety ◽  
Static Game ◽  
Safety Issues ◽  
Value Perception ◽  
Safety Mechanism ◽  
Psychology And Economics ◽  
Food Quality And Safety ◽  
Food Market

Behavior strategy of food enterprises exerts a direct influence on food quality and safety. Against the backdrop of value perception differences on food quality and safety between different food enterprises, this paper establishes a static game model and based on prospect theory, explores the reasons for food quality and safety issues in our food market from the perspectives of psychology and economics. Finally, it presents a more scientific food quality and safety mechanism and countermeasures.

Safety analysis for thread pair clearance of safety mechanism of Three Gorges Project ship lift

2014 ◽  
Vol 19 (6) ◽  
pp. 535-543
Author(s):  
Duanwei Shi ◽  
Shuxiao Cheng ◽  
Tiezhu Zhao ◽  
Hui Peng ◽  
Yongbo Wang
Keyword(s):  
Safety Analysis ◽  
Three Gorges Project ◽  
Three Gorges ◽  
Safety Mechanism ◽  
Ship Lift

scholarly journals Spatial signals link exit from mitosis to spindle position

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Jill Elaine Falk ◽  
Dai Tsuchiya ◽  
Jolien Verdaasdonk ◽  
Soni Lacefield ◽  
Kerry Bloom ◽  
...  
Keyword(s):  
Spindle Pole ◽  
Mitotic Exit ◽  
Zone Model ◽  
Cytoplasmic Microtubule ◽  
Binucleate Cells ◽  
Spindle Pole Bodies ◽  
Mitotic Exit Network ◽  
Bud Neck ◽  
Competing Models ◽  
Spindle Position

In budding yeast, if the spindle becomes mispositioned, cells prevent exit from mitosis by inhibiting the mitotic exit network (MEN). The MEN is a signaling cascade that localizes to spindle pole bodies (SPBs) and activates the phosphatase Cdc14. There are two competing models that explain MEN regulation by spindle position. In the 'zone model', exit from mitosis occurs when a MEN-bearing SPB enters the bud. The 'cMT-bud neck model' posits that cytoplasmic microtubule (cMT)-bud neck interactions prevent MEN activity. Here we find that 1) eliminating cMT– bud neck interactions does not trigger exit from mitosis and 2) loss of these interactions does not precede Cdc14 activation. Furthermore, using binucleate cells, we show that exit from mitosis occurs when one SPB enters the bud despite the presence of a mispositioned spindle. We conclude that exit from mitosis is triggered by a correctly positioned spindle rather than inhibited by improper spindle position.

New Product Decisions - The Process and Outcome for a Community Health System

2011 ◽  
Vol 16 (2) ◽  
pp. 74-84 ◽  
Author(s):  
Jose Delp ◽  
Lynn Hadaway
Keyword(s):  
Clinical Outcomes ◽  
Patient Outcomes ◽  
Negative Impact ◽  
Relevant Literature ◽  
Outcome Data ◽  
Passive Safety ◽  
Radiology Department ◽  
Complication Rates ◽  
Safety Mechanism ◽  
Catheter System

Abstract Purpose: To compare patient outcomes and evaluate safety features and costs associated with a new catheter system and securement dressing. Background: The need to improve dwell times for short peripheral catheters and reduce complication rates, along with improvements in clinical practice in radiology and enhanced staff safety were driving factors leading to a change in peripheral catheters and securement systems. Review of Relevant Literature: Several reports of catheter stabilization devices have shown improved clinical outcomes with their use. Currently available studies on this new catheter system include one small evaluation and a randomized trial comparing a traditional round hub catheter coupled with a supplemental securement device and the new catheter system with an integrated stabilization platform combined with a securement dressing. Passive safety mechanisms on peripheral catheters may produce fewer needlestick injuries than mechanisms requiring the user to activate the device. Methods: After a learning period, the following seven months were designated the intervention period. Outcome data from the same seven-month period of the preceding year were used for comparison. The data were divided into scheduled and unscheduled restarts. Data from two hospitals are reported separately and in combination. Data from the two periods were analyzed for equivalence or noninferiority. Results: Clinical outcomes for both periods are virtually equivalent, demonstrating that one system is not inferior to the other regarding catheter complications. However the catheter system with the integrated stabilization platform was less costly and safer due to a passive safety mechanism. Problems with high pressure injection in the radiology department were also solved with the new catheter system. Conclusions: While any product change can be a challenging experience, we accomplished these changes in an orderly manner without negative impact on patient outcomes and reducing costs. Improvements in radiology were also attributed to these changes, along with enhanced staff safety. Implications for Practice: The catheter designed with an integrated stabilization platform, a pre-attached extension set, and a passive safety mechanism produced benefits for radiology staff without negatively affecting patient outcomes in other clinical areas. These product changes were implemented in an organized manner and involved all stakeholders in the process.

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