Faculty Opinions recommendation of Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target.

2010 ◽  
Author(s):  
Antonio Cassone
Keyword(s):  
Candida Albicans ◽  
Vaccine Target ◽  
Potential Vaccine

scholarly journals Candida albicansHyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target

2010 ◽  
Vol 201 (11) ◽  
pp. 1718-1728 ◽  
Author(s):  
Guanpingsheng Luo ◽  
Ashraf S. Ibrahim ◽  
Brad Spellberg ◽  
Clarissa J. Nobile ◽  
Aaron P. Mitchell ◽  
...  
Keyword(s):  
Vaccine Target ◽  
Potential Vaccine

scholarly journals Leishmania donovani Triose Phosphate Isomerase: A Potential Vaccine Target against Visceral Leishmaniasis

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45766 ◽  
Author(s):  
Pramod K. Kushawaha ◽  
Reema Gupta ◽  
Chandra Dev Pati Tripathi ◽  
Prashant Khare ◽  
Anil Kumar Jaiswal ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Leishmania Donovani ◽  
Triose Phosphate Isomerase ◽  
Vaccine Target ◽  
Triose Phosphate ◽  
Potential Vaccine

Designing an efficient multi-epitope oral vaccine against Helicobacter pylori using immunoinformatics and structural vaccinology approaches

2017 ◽  
Vol 13 (4) ◽  
pp. 699-713 ◽  
Author(s):  
Navid Nezafat ◽  
Mahboobeh Eslami ◽  
Manica Negahdaripour ◽  
Mohammad Reza Rahbar ◽  
Younes Ghasemi
Keyword(s):  
Helicobacter Pylori ◽  
Oral Vaccine ◽  
Oral Immunization ◽  
Vaccine Target ◽  
Structural Vaccinology ◽  
Potential Vaccine

In this study, we have applied bioinformatics approaches to design potential vaccine target for oral immunization against Helicobacter pylori.

scholarly journals Quest for a broad-range vaccine against Neisseria meningitidis serogroup B: implications of genetic variations of the surface-exposed proteins

2009 ◽  
Vol 58 (9) ◽  
pp. 1127-1132 ◽  
Author(s):  
Ivano de Filippis
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
External Environment ◽  
Genetic Variations ◽  
Emerging Diseases ◽  
Carrier Protein ◽  
Vaccine Target ◽  
Successful Approach ◽  
Potential Vaccine

Despite the development of new vaccine formulations using new biotechnology resources to combat emerging and re-emerging diseases, serogroup B meningococcal disease is still a worldwide burden, accounting for many deaths and disabilities every year. The successful approach of coupling a polysaccharide (PS) with a carrier protein in order to increase long-lasting immunity could not be exploited against Neisseria meningitidis B because of the limitations of using the capsular PS of serogroup B meningococci. Tailor-made vaccines based on exposed proteins were shown to be a promising approach to overcome these flaws. However, the continuous adaptation of surface meningococcal structures to the external environment has led to genetic shifts of potential vaccine-target epitopes, hampering the quest for a broad-range vaccine that could be used against all serogroups, especially against serogroup B.

scholarly journals Staphylococcus aureusClumping Factor A Remains a Viable Vaccine Target for Prevention ofS. aureusInfection

mBio ◽  
2016 ◽  
Vol 7 (2) ◽  
Author(s):  
Annaliesa S. Anderson ◽  
Ingrid L. Scully ◽  
Ed T. Buurman ◽  
Joseph Eiden ◽  
Kathrin U. Jansen
Keyword(s):  
Staphylococcus Aureus ◽  
Recent Article ◽  
Biological Role ◽  
Vaccine Antigen ◽  
Disease Models ◽  
Vaccine Target ◽  
Link Type ◽  
Positive Data ◽  
Potential Vaccine

ABSTRACTIn a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016,http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of theStaphylococcus aureusprotein clumping factor A (ClfA) in protecting mice fromS. aureusinfection. ClfA, one of the first proteins to be identified as a potential vaccine antigen forS. aureusprophylaxis, is currently a component of several investigational vaccines. The authors conclude that ClfA may not be effective forS. aureusprophylaxis. In contrast, previously published papers reporting positive data suggested that ClfA was potentially an important vaccine target to prevent invasiveS. aureusdisease. This commentary addresses the observed differences between the findings of Li et al. and those from other publications, highlighting the importance for preclinical vaccine antigen assessments to reflect the biological role of said antigen in virulence and, consequently, the importance of choosing appropriate preclinical disease models to test such antigens.

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