Faculty Opinions recommendation of Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: a DTI-tractography study.

BackgroundSubstance misuse is a common comorbid problem in people presenting with first-episode psychosis and is associated with a poor short-term outcome.AimsThe aim of this study is to examine differences in baseline characteristics and 1-year outcome between individuals with first-episode psychosis who have never misused substances, those who stop misusing substances after initial presentation and those who persistently misuse substances over the 1-year assessment period.MethodPatients were recruited to the Northern Ireland First Episode Psychosis Study (n = 272). Clinical assessments were performed at baseline and at 1 year (n = 194) and data were collected from the case notes.ResultsIndividuals with persistent substance misuse had more severe depression, more positive symptoms, poorer functional outcome and greater rates of relapse at 1 year than those who stopped and those who had never misused substances. There were no differences in outcome between people who had never misused substances and those who stopped misusing after presentation.These results support assertive intervention targeted at comorbid substance misuse in individuals with first-episode psychosis.

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Social Cognitive Markers of Short-Term Clinical Outcome in First-Episode Psychosis

Clinical Schizophrenia & Related Psychoses ◽

10.3371/csrp.4.2.2 ◽

2010 ◽

Vol 4 (2) ◽

pp. 105-114 ◽

Cited By ~ 13

Author(s):

Tina Montreuil ◽

Michael Bodnar ◽

Marie-Claude Bertrand ◽

Ashok Malla ◽

Ridha Joober ◽

...

Keyword(s):

Clinical Outcome ◽

Social Cognitive ◽

First Episode Psychosis ◽

First Episode ◽

Short Term ◽

Cognitive Markers ◽

Episode Psychosis

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Faculty Opinions recommendation of [CONFERENCE POSTER]: Comorbid anxiety and short-term clinical outcome in first episode psychosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11423956.12445054 ◽

2011 ◽

Author(s):

Barbara Cornblatt ◽

Doreen Olvet

Keyword(s):

Clinical Outcome ◽

First Episode Psychosis ◽

First Episode ◽

Short Term ◽

Comorbid Anxiety ◽

Episode Psychosis

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Impact of duration of untreated psychosis in short‐term response to treatment and outcome in antipsychotic naïve first‐episode psychosis

Early Intervention in Psychiatry ◽

10.1111/eip.12889 ◽

2019 ◽

Vol 14 (6) ◽

pp. 677-683 ◽

Cited By ~ 2

Author(s):

Daniel A. Cavalcante ◽

Luccas S. Coutinho ◽

Bruno B. Ortiz ◽

Mariane N. Noto ◽

Quirino Cordeiro ◽

...

Keyword(s):

First Episode Psychosis ◽

Response To Treatment ◽

First Episode ◽

Duration Of Untreated Psychosis ◽

Short Term ◽

Episode Psychosis ◽

Term Response

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Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase

The British Journal of Psychiatry ◽

10.1192/bjp.bp.114.150623 ◽

2015 ◽

Vol 207 (2) ◽

pp. 130-134 ◽

Cited By ~ 45

Author(s):

Lucia R. Valmaggia ◽

Majella Byrne ◽

Fern Day ◽

Matthew R. Broome ◽

Louise Johns ◽

...

Keyword(s):

Minority Group ◽

First Episode Psychosis ◽

First Episode ◽

First Year ◽

Compulsory Treatment ◽

Duration Of Untreated Psychosis ◽

Short Term ◽

Prodromal Phase ◽

Episode Psychosis ◽

Poor Outcomes

BackgroundIt is unknown whether prodromal services improve outcomes in those who go on to develop psychosis, and whether these patients are demographically different from the overall first-episode population.AimsTo compare sociodemographic features, duration of untreated psychosis, hospital admission and frequency of compulsory treatment in the first year after the onset of psychosis in patients who present to prodromal services with patients who did not present to services until the first episode of psychosis.MethodWe compared two groups of patients with first-episode psychosis: one who made transition after presenting in the prodromal phase and the other who had presented with a first episode.ResultsThe patients who had presented before the first episode were more likely to be employed and less likely to belong to an ethnic minority group. They had a shorter duration of untreated psychosis, and were less likely to have been admitted to hospital and to have required compulsory treatment.ConclusionsPatients who develop psychosis after being engaged in the prodromal phase have a better short-term clinical outcome than patients who do not present until the first episode. Patients who present during first episodes may be more likely to have sociodemographic features associated with relatively poor outcomes.

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