Faculty Opinions recommendation of Is pulse oximetry an essential tool or just another distraction? The role of the pulse oximeter in modern anesthesia care.

Respiratory rate (RR) is a valuable early marker of illness in vulnerable infants, but current monitoring methods are unsuitable for sustained home use. We have demonstrated accurate measurement of RR from brief recordings of pulse oximeter plethysmogram (pleth) trace in full-term neonates in hospital. This study assessed the feasibility of this method in preterm infants during overnight recordings in the home. We collected simultaneous overnight SpO2, pleth and respiratory inductive plethysmography (RIP) on 24 preterm infants in the home. RR from pleth analysis was compared with RR from RIP bands; pleth quality was assessed by the presence of visible artefact. Median (range) RR from RIP and pleth were not significantly different at 42 (25–65) and 42 (25–64) breaths/min. Median (range) % of epochs rejected due to artefact was 20 (8–75) for pleth and 10 (3–53) for RIP. Our results suggest that home RR monitoring by pulse oximeter pleth signal is accurate and feasible.

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Pulse Oximetry: An Alternative Method for the Assessment of Oxygenation in Newborn Infants

PEDIATRICS ◽

10.1542/peds.79.4.524 ◽

1987 ◽

Vol 79 (4) ◽

pp. 524-528

Author(s):

Michael S. Jennis ◽

Joyce L. Peabody

Keyword(s):

Pulse Oximetry ◽

Pulse Oximeter ◽

Arterial Oxygen Saturation ◽

Newborn Infants ◽

Fetal Hemoglobin ◽

Arterial Oxygen ◽

Skin Injury ◽

Reliable Technique ◽

Arterial Blood

Continuous monitoring of oxygenation in sick newborns is vitally important. However, transcutaneous Po2 measurements have a number of limiations. Therefore, we report the use of the pulse oximeter for arterial oxygen saturation (Sao2) determination in 26 infants (birth weights 725 to 4,000 g, gestational ages 24 to 40 weeks, and postnatal ages one to 49 days). Fetal hemoglobin determinations were made on all infants and were repeated following transfusion. Sao2, readings from the pulse oximeter were compared with the Sao2 measured in vitro on simultaneously obtained arterial blood samples. The linear regression equation for 177 paired measurements was: y = 0.7x + 27.2; r = .9. However, the differences between measured Sao2 and the pulse oximeter Sao2 were significantly greater in samples with > 50% fetal hemoglobin when compared with samples with < 25% fetal hemoglobin (P < .001). The pulse oximeter was easy to use, recorded trends in oxygenation instantaneously, and was not associated with skin injury. We conclude that pulse oximetry is a reliable technique for the continuous, noninvasive monitoring of oxygenation in newborn infants.

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CONTINUOUS PULSE OXIMETRY IN THE POST-ANESTHESIA CARE UNIT

Anesthesia & Analgesia ◽

10.1213/00000539-199002001-00077 ◽

1990 ◽

Vol 70 (Supplement) ◽

pp. S77 ◽

Cited By ~ 1

Author(s):

M D Daley ◽

M E Colaenares ◽

A N Sandler ◽

P H Norman

Keyword(s):

Pulse Oximetry ◽

Anesthesia Care ◽

Post Anesthesia Care Unit ◽

Continuous Pulse

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The unresolved role of cardiotocography (CTG), fetal ECG (STAN) and intrapartum fetal pulse oximetry (IFPO) as diagnostic methods for fetal hypoxia

Journal of Obstetrics and Gynaecology ◽

10.3109/01443615.2014.920797 ◽

2014 ◽

Vol 34 (8) ◽

pp. 757-757 ◽

Cited By ~ 2

Author(s):

S. L. Sholapurkar

Keyword(s):

Pulse Oximetry ◽

Diagnostic Methods ◽

Fetal Hypoxia ◽

Fetal Ecg ◽

Fetal Pulse Oximetry

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sRNA/L1 retrotransposition: using siRNAs and miRNAs to expand the applications of the cell culture-based LINE-1 retrotransposition assay

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2019.0346 ◽

2020 ◽

Vol 375 (1795) ◽

pp. 20190346 ◽

Cited By ~ 2

Author(s):

Pablo Tristan-Ramos ◽

Santiago Morell ◽

Laura Sanchez ◽

Belen Toledo ◽

Jose L. Garcia-Perez ◽

...

Keyword(s):

Cell Culture ◽

Gene Regulation ◽

Small Rna ◽

Host Factors ◽

Fanconi Anaemia ◽

Reporter Assay ◽

Long Interspersed Elements ◽

Essential Tool ◽

Conventional Cell

The cell culture-based retrotransposition reporter assay has been (and is) an essential tool for the study of vertebrate Long INterspersed Elements (LINEs). Developed more than 20 years ago, this assay has been instrumental in characterizing the role of LINE-encoded proteins in retrotransposition, understanding how ribonucleoprotein particles are formed, how host factors regulate LINE mobilization, etc. Moreover, variations of the conventional assay have been developed to investigate the biology of other currently active human retrotransposons, such as Alu and SVA. Here, we describe a protocol that allows combination of the conventional cell culture-based LINE-1 retrotransposition reporter assay with short interfering RNAs (siRNAs) and microRNA (miRNAs) mimics or inhibitors, which has allowed us to uncover specific miRNAs and host factors that regulate retrotransposition. The protocol described here is highly reproducible, quantitative, robust and flexible, and allows the study of several small RNA classes and various retrotransposons. To illustrate its utility, here we show that siRNAs to Fanconi anaemia proteins (FANC-A and FANC-C) and an inhibitor of miRNA-20 upregulate and downregulate human L1 retrotransposition, respectively. This article is part of a discussion meeting issue ‘Crossroads between transposons and gene regulation’.

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The Role of Pulse Oximetry in the Initial Airway Management of Helicopter Transported, Trauma Victims

Prehospital and Disaster Medicine ◽

10.1017/s1049023x00039625 ◽

1992 ◽

Vol 7 (3) ◽

pp. 277-278

Author(s):

Ross S. Carol ◽

Francis P. Renzi

Keyword(s):

Airway Management ◽

Pulse Oximetry ◽

Clinical Signs ◽

Management Decision ◽

Trauma Patients ◽

Arterial Blood Gas ◽

Arterial Blood ◽

Prehospital Management ◽

A Prospective Study

AbstractIntroduction:Circumstances surrounding the prehospital management of trauma patients may mask clinical signs of inadequate oxygenation. Pulse oximetry (PO) may influence airway management prior to helicopter transport by helping to identify patients with occult hypoxemia.Methods:Patients were enrolled in a prospective study. Initially, the flight physician clinically decided how best to manage the patient's airway prior to helicopter transport. The patient's oxygenation saturation (O2at), was determined by PO. Then, the physician reassessed the initial airway management decision based on clinical assessment and knowledge of the O2Sat. All patients had an arterial blood gas (ABG) measurement taken after completion of transport.Results:Sixty patients were enrolled. Knowledge of the O2Sat, as determined by pulse oximetry, did not influence airway management. No patients with occult hypoxemia were identified.Conclusion:The use of PO in the initial evaluation of trauma patients prior to helicopter transport did not influence the flight physician's initial management of the airway.

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