Faculty Opinions recommendation of Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials.

2017 ◽  
Author(s):  
Martin Aringer
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Randomized Clinical Trials ◽  
Digital Ulcers

scholarly journals Capillaroscopy as an Outcome Measure for Clinical Trials on the Peripheral Vasculopathy in SSc—Is It Useful?

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Maurizio Cutolo ◽  
Alberto Sulli ◽  
Carmen Pizzorni ◽  
Vanessa Smith
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Outcome Measure ◽  
Digital Ulcers ◽  
Nailfold Videocapillaroscopy ◽  
Therapeutic Trials ◽  
Specific Serum ◽  
Pulmonary Arterial ◽  
Microvascular Impairment ◽  
Clinical Conditions

Peripheral microvascular impairment in systemic sclerosis (SSc) may be easily detected and scored in a safe noninvasive way by nailfold videocapillaroscopy (NVC). The paper highlights clinical conditions related to SSc in which NVC may represent an outcome measure of therapeutical interventions, by elaborating on their already assessed relationship with the NVC patterns and eventually scores. The 3 important biological/clinical conditions are: the positivity for SSc-specific serum autoantibodies, the presence of SSc skin digital ulcers (DUs) and of pulmonary arterial hypertension (PAH) SSc associated. In conclusion, to the question if capillaroscopy (NVC) may represent in SSc an outcome measure for clinical trials on the peripheral vasculopathy, based on the growing evidence and our detailed studies, the answer is positive. Recent therapeutic trials in SSc are confirming this role, and the experience is growing rapidly.

scholarly journals Gender and ethnicity differences in patients with diffuse systemic sclerosis--analysis from three large randomized clinical trials

Rheumatology ◽  
2010 ◽  
Vol 50 (2) ◽  
pp. 335-342 ◽  
Author(s):  
M. Nashid ◽  
P. P. Khanna ◽  
D. E. Furst ◽  
P. J. Clements ◽  
P. Maranian ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Randomized Clinical Trials ◽  
Diffuse Systemic Sclerosis ◽  
Ethnicity Differences

Complementary therapies for patients with systemic sclerosis

2019 ◽  
Vol 4 (3) ◽  
pp. 187-199
Author(s):  
Kimberly Showalter ◽  
Aileen Hoffmann ◽  
Nicole DeCredico ◽  
Anjali Thakrar ◽  
Esperanza Arroyo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Complementary Therapies ◽  
Randomized Clinical Trials ◽  
Essential Fatty Acids ◽  
Current Data ◽  
Study Results

Patients with systemic sclerosis often seek information regarding complementary and nutrition-based therapy. Some study results have shown that vitamins D and E, probiotics, turmeric, l-arginine, essential fatty acids, broccoli, biofeedback, and acupuncture may be beneficial in systemic sclerosis care. However, large randomized clinical trials have not been conducted. This review summarizes current data regarding various complementary therapies in systemic sclerosis and concludes with recommendations.

scholarly journals Should all digital ulcers be included in future clinical trials of systemic sclerosis-related digital vasculopathy?

2018 ◽  
Vol 116 ◽  
pp. 101-104 ◽  
Author(s):  
Michael Hughes ◽  
Andrea Murray ◽  
Christopher P. Denton ◽  
Ariane L. Herrick
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Digital Ulcers

scholarly journals Review of local wound management for scleroderma-associated digital ulcers

2017 ◽  
Vol 3 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Nicholas Lebedoff ◽  
Tracy M. Frech ◽  
Victoria K. Shanmugam ◽  
Aryeh Fischer ◽  
Daniel Erhardt ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Expert Opinion ◽  
Current Literature ◽  
Wound Care ◽  
Clinical Problem ◽  
Wound Management ◽  
Digital Ulcers ◽  
Pharmacological Management ◽  
Common Clinical Problem

Digital ulcers (DU) are a common clinical problem in systemic sclerosis (SSc); however, there is no standardization of local wound care protocols for management of these lesions. There is a well-recognized need to develop and standardize non-pharmacological management of DU in patients with SSc, and to adopt these protocols in future clinical trials that focus on DU healing. The purpose of this review is to outline the types of DU that occur in SSc, and provide an update on the principles of wound management for these lesions based on the current literature and expert opinion.

An update on recent randomized clinical trials in systemic sclerosis

2021 ◽  
pp. 105184
Author(s):  
Gonçalo Boleto ◽  
Jérôme Avouac ◽  
Yannick Allanore
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Randomized Clinical Trials

scholarly journals PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers: Current Status of Clinical Trials

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Ann J. Impens ◽  
Kristine Phillips ◽  
Elena Schiopu
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Peripheral Circulation ◽  
Current Status ◽  
Digital Ulcers ◽  
Raynaud Phenomenon ◽  
Current State ◽  
Significant Barrier ◽  
Significant Impairment

Systemic sclerosis- (SSc-) related vasculopathy, as manifested by Raynaud's Phenomenon (RP) and digital ulcers (DUs), is associated with significant impairment of the quality of life and morbidity. The current vasoactive approach for SSc-RP, although employing vasodilators, is entirely off-label. PDE-5 inhibitors improve peripheral circulation, are well tolerated, and are widely used for various forms of constrictive vasculopathies. This class of medications has become one of the first lines of treatment of SSc-RP and SSc-DUs among rheumatologists that routinely treat SSc patients. Due to the lack of robust randomized clinical trials of PDE-5 inhibitors in SSc-RP/DUs, the PDE-5 inhibitors have not been FDA approved for these particular indications, which constitutes a significant barrier to prescribing this category of drugs. This paper reviews the current state of evidence-based knowledge in SSc-related vasculopathy and the use of PDE-5 inhibitors.

scholarly journals Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study

2016 ◽  
Vol 46 (3) ◽  
pp. 344-349 ◽  
Author(s):  
Antonia Valenzuela ◽  
Murray Baron ◽  
Ariane L. Herrick ◽  
Susanna Proudman ◽  
Wendy Stevens ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Systemic Sclerosis ◽  
Digital Ulcers
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