Faculty Opinions recommendation of Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Author(s):  
Kellie Mathis
Cancer ◽  
2016 ◽  
Vol 123 (8) ◽  
pp. 1434-1441 ◽  
Author(s):  
Yvonne M. Mowery ◽  
Joseph K. Salama ◽  
S. Yousuf Zafar ◽  
Harvey G. Moore ◽  
Christopher G. Willett ◽  
...  

1935 ◽  
Vol 1 (4) ◽  
pp. 514-521

Theobald Smith, son of Philip Smith by his wife Theresa nee Kexel, was born at Albany, New York, on July 31, 1859. He was educated at public schools there and afterwards went to Cornell University, where he graduated as B.Phil. in 1881. His material circumstances being small, and failing to obtain a post as school teacher, he resolved to study medicine and went to Albany Medical College of Union University whence he graduated as M.D. in 1883, after attending the very short course then prevailing in some medical schools in the United States. He was studious and already widely read as a youth. Being possessed of the good judgement which characterized him throughout life, he was clear in his mind that his training was insufficient to qualify him as a medical practitioner. At Cornell, he worked under two remarkable teachers, Professors Gage and Wilder, with great benefit as he afterwards acknowledged.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S101-S102
Author(s):  
James Go ◽  
Sarah Cotner ◽  
Donna R Burgess ◽  
David Burgess ◽  
Katie Wallace ◽  
...  

Abstract Background Bloodstream infections (BSI) continue to be a major cause of morbidity and mortality in the United States; thus, the correct choice of antibiotics for an appropriate duration is imperative. However, there are limited recommendations on adequate duration of treatment of bacteremia caused by Gram-negative organisms. Therefore, treating an infection for an adequate duration to prevent complications while preventing adverse effects from unnecessary antibiotic exposure remains a balancing act. This study aims to compare clinical outcomes between patients treated with a short (7–10 days) vs. long (11–20 days) course of antibiotics for uncomplicated gram-negative bacteremia. Methods This single-center retrospective cohort study evaluated adult patients admitted between January 2007 to October 2018 with a blood culture positive for gram-negative bacteria. Data came from the University of Kentucky Microbiological Laboratory and Center for Clinical and Translational Science (CCTS) Data Bank. Patients included must have received appropriate antibiotics for at least 7 days. Appropriate antibiotics were defined as those to which the organism is susceptible with day one of therapy as the first day of appropriate antibiotic therapy. Patients were excluded if they were treated with aminoglycoside monotherapy, had polymicrobial bacteremia, or if treated for longer than 20 days of therapy. Results A total of 466 patients were identified (208 in the short-course group and 258 in the long course group). Gender and ethnicity were similar across both groups. The patients in the long course group had more ICU admissions compared with the short-course group (52.7% vs. 43.3%, P = 0.0426), tended to be older (57 ± 16.7 vs. 53 ± 15.9 years, P = 0.0119), had a higher Charlson Comorbidity Index (5.7 ± 3.6 vs. 4.6 ± 3.6, P = 0.0009) and remained admitted to the hospital longer (23.2 ± 25.6 vs. 15.8 ± 17.5 days, P = 0.0002). However, patients treated with a long course had no difference in 30-day mortality compared with the short-course group (3.9% vs. 3.4%, P = 0.7701). Conclusion Patients with an uncomplicated gram-negative BSI treated with a short course (7–10 days) of antibiotics do not appear to have a significant difference in 30-day mortality compared with those patients treated with a long course (11–20 days). Disclosures All authors: No reported disclosures.


Author(s):  
B. Adefres ◽  
T.Q. Huang ◽  
F.I. Chu ◽  
E.M. Chang ◽  
A. Raldow

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