F1000Prime recommendation of Does Clearance of Positive Margins Improve Local Control in Oral Cavity Cancer? A Meta-analysis.

2020 ◽  
Author(s):  
Anil D'Cruz ◽  
Harsh Dhar ◽  
Richa Vaish
Keyword(s):  
Oral Cavity ◽  
Local Control ◽  
Oral Cavity Cancer ◽  
Meta Analysis ◽  
Positive Margins

Does Clearance of Positive Margins Improve Local Control in Oral Cavity Cancer? A Meta-analysis

2019 ◽  
Vol 161 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Mustafa G. Bulbul ◽  
Osama Tarabichi ◽  
Rosh K. Sethi ◽  
Anuraag S. Parikh ◽  
Mark A. Varvares
Keyword(s):  
Local Recurrence ◽  
Oral Cavity ◽  
Local Control ◽  
English Language ◽  
Oral Cavity Cancer ◽  
Frozen Section ◽  
Meta Analysis ◽  
Resected Specimen ◽  
Positive Margins ◽  
Meta Analyses

Objectives To compare local recurrence-free survival (LRFS) in early oral cavity cancer (OCC) patients with positive/close frozen section (FS) cleared with further resection (R1 to R0) or positive FS not cleared (R1) to those with negative margins on initial FS analysis (R0). Data Sources PubMed, EMBASE, and Cochrane. Review Methods We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) for reporting in our study. Only English-language articles that included patients with OCC and local recurrence (LR) comparisons between R0 and initially R1 to final R0 or final R1 groups were included. We requested the raw data from the corresponding authors of eligible studies and performed an individual participant data (IPD) meta-analysis of LRFS outcomes across groups. Results Pooled LRFS data from 8 studies showed that patients in the R1 to R0 group had worse LRFS compared to the R0 group (hazard ratio [HR] = 2.897, P < .001). Patients in the R1 group were also found to have worse LRFS compared to the R0 group (HR = 3.795, P < .001). When compared to final R1 group, the initially R1 to final R0 only showed a trend toward better LRFS. Conclusion Margin revision of initially positive margins to “clear” based on FS guidance does not equate to an initially negative margin and does not significantly improve local control. These findings call into question the effectiveness of the current methodology of intraoperative FS in OCC resections and call for a prospective study to determine what system of resected specimen analysis best predicts completeness of resection.

scholarly journals Meta-Analysis on the diagnostic significance of p16INK4A and HR-HPV DNA in identifying HPV-driven oral cavity cancer

2020 ◽  
Author(s):  
T Obermüller ◽  
Veit Maria Hofmann ◽  
M von Bernstorff ◽  
A Pudszuhn ◽  
Elena-Sophie Prigge
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Meta Analysis ◽  
Diagnostic Significance ◽  
Hpv Dna

scholarly journals Nonsurgical management of resectable oral cavity cancer in the wake of COVID-19: A rapid review and meta-analysis

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104849 ◽  
Author(s):  
David Forner ◽  
Christopher W. Noel ◽  
Vincent Wu ◽  
Ambica Parmar ◽  
Kelvin K.W. Chan ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Meta Analysis ◽  
Rapid Review ◽  
Nonsurgical Management

The Prognostic Value of Lymph Node Burden in Oral Cavity Cancer: Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Tsung‐You Tsai ◽  
Andrea Iandelli ◽  
Filippo Marchi ◽  
Yenlin Huang ◽  
Shiao‐Fwu Tai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Oral Cavity ◽  
Prognostic Value ◽  
Oral Cavity Cancer ◽  
Meta Analysis

scholarly journals Association between smokeless tobacco use and oral cavity cancer risk in women compared with men: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guangyan Mu ◽  
Jiayi Wang ◽  
Zhiyan Liu ◽  
Hanxu Zhang ◽  
Shuang Zhou ◽  
...  
Keyword(s):  
Relative Risk ◽  
Oral Cavity ◽  
Smokeless Tobacco ◽  
Oral Cavity Cancer ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Cochrane Library ◽  
Comparison Results ◽  
Increased Risk ◽  
The Impact

Abstract Background The impact of smokeless tobacco (SLT) use on the risk of oral cavity cancer (OCC) has been confirmed; however, the sex-based difference in this association remains inconclusive. Therefore, this study aimed to estimate the association between SLT use and OCC risk in women and compared it to that in men. Methods PubMed, Embase, and Cochrane Library databases were systematically searched for eligible studies from their inception up to August 2020. Studies reporting the effect estimates of SLT use on OCC risk in men and women, were eligible for inclusion. The relative risk ratio (RRR) was applied to calculate the sex-based difference in the relationship between SLT use and OCC risk, and pooled analysis was conducted using a random-effects model with inverse variance weighting. Results Nineteen studies reporting a total of 6593 OCC cases were included in the final meta-analysis. The pooled relative risk (RR) suggested that SLT use was associated with an increased risk of OCC in both men (RR, 2.94; 95% confidence interval [CI], 2.05–4.20; P < 0.001) and women (RR, 6.39; 95%CI, 3.16–12.93; P < 0.001). Moreover, the SLT-use-related risk of OCC was higher in women than that in men (RRR,1.79; 95%C, 1.21–2.64; P = 0.003). The risk of OCC related to SLT use in women was still significantly higher than that in men (RRR, 1.75; 95%CI, 1.15–2.66; P = 0.008) after excluding indirect comparison results. Finally, a subgroup analysis suggested significant sex-based differences only in individuals who received chewed smokeless products, regardless of the control definition. Pooled analysis of studies with high design quality confirmed the notably higher risk of OCC in women than in men. Conclusions This study found that SLT use was associated with a higher risk of OCC in women than in men. Further large-scale prospective cohort studies should be conducted to verify sex-based differences in the association between use of specific smokeless products and OCC risk.

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