Faculty Opinions recommendation of Heat Shock Protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.

2019 ◽  
Author(s):  
Achsah Keegan ◽  
Svetlana P Chapoval
Keyword(s):  
Heat Shock ◽  
Mouse Model ◽  
Heat Shock Protein ◽  
Airway Inflammation ◽  
Goblet Cell ◽  
Heat Shock Protein 70 ◽  
Allergic Airway Inflammation ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Positive Regulator

scholarly journals Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation

2009 ◽  
Vol 58 (1) ◽  
pp. 125-134 ◽  
Author(s):  
Kohei Yamauchi ◽  
Hong Mei Piao ◽  
Toshihide Nakadate ◽  
Toshiki Shikanai ◽  
Yutaka Nakamura ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Goblet Cell ◽  
Knockout Mice ◽  
Allergic Airway Inflammation ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia

Effects of Heat Shock Protein 70 kDa in Allergic Airway Inflammation

2020 ◽  
Author(s):  
Marina A. Shevchenko ◽  
Natalia I. Troyanova ◽  
Alexander M. Sapozhnikov
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Airway Inflammation ◽  
Heat Shock Protein 70 ◽  
Allergic Airway Inflammation

Resistin-like molecule-β is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung

2007 ◽  
Vol 293 (2) ◽  
pp. L305-L313 ◽  
Author(s):  
Anil Mishra ◽  
Meiqin Wang ◽  
James Schlotman ◽  
Nikolaos M. Nikolaidis ◽  
Charles W. DeBrosse ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Goblet Cell ◽  
Allergic Airway Inflammation ◽  
Mouse Lung ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia ◽  
Leukocyte Accumulation

Resistin-like molecule (RELM)-β is a cysteine-rich cytokine implicated in insulin resistance and asthmatic responses, but its function remains an enigma. We now report that RELM-β has a role in promoting airway inflammation and lung remodeling in the mouse lung. RELM-β is strongly induced by diverse allergens and T helper type 2 (Th2) cytokines by an IL-13- and STAT6-dependent mechanism. To understand the in vivo role of RELM-β, we delivered recombinant murine RELM-β intratracheally to naïve mice. RELM-β induced dose-dependent leukocyte accumulation (most prominently involving macrophages) and goblet cell hyperplasia. The most prominent effect induced by RELM-β was increased perivascular and peribronchial collagen deposition. Mice genetically deficient in RELM-β had reduced accumulation of collagen and goblet cell hyperplasia in an experimental model of allergic airway inflammation. In vitro experiments demonstrated that RELM-β had fibroblast motogenic activity. These results identify RELM-β as a Th2-associated cytokine with potent inflammatory and remodeling activity.

scholarly journals Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage

2010 ◽  
Vol 57 (7) ◽  
pp. 844-850 ◽  
Author(s):  
Anatol Manaenko ◽  
Nancy Fathali ◽  
Hank Chen ◽  
Hidenori Suzuki ◽  
Shammah Williams ◽  
...  
Keyword(s):  
Brain Injury ◽  
Heat Shock ◽  
Mouse Model ◽  
Heat Shock Protein ◽  
Intracerebral Hemorrhage ◽  
Heat Shock Protein 70

scholarly journals TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis

2010 ◽  
Vol 59 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Yuhui Ouyang ◽  
Masanori Miyata ◽  
Kyosuke Hatsushika ◽  
Yuko Ohnuma ◽  
Ryohei Katoh ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Goblet Cell ◽  
Cell Hyperplasia ◽  
Goblet Cell Hyperplasia
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