Faculty Opinions recommendation of Viral delivery of GDNF promotes functional integration of human stem cell grafts in parkinson's disease.

2020 ◽  
Author(s):  
Jun Takahashi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Functional Integration ◽  
Human Stem Cell

scholarly journals Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

2020 ◽  
Vol 26 (4) ◽  
pp. 511-526.e5 ◽  
Author(s):  
Carlos W. Gantner ◽  
Isabelle R. de Luzy ◽  
Jessica A. Kauhausen ◽  
Niamh Moriarty ◽  
Jonathan C. Niclis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Functional Integration ◽  
Human Stem Cell

scholarly journals Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models

2020 ◽  
Vol 13 ◽  
Author(s):  
Katrin Simmnacher ◽  
Jonas Lanfer ◽  
Tania Rizo ◽  
Johanna Kaindl ◽  
Beate Winner
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Cell Interactions ◽  
Human Stem Cell ◽  
Cell Cell

Stem cell deficiency in Parkinson's disease

2005 ◽  
Vol 32 (06) ◽  
Author(s):  
GU Höglinger ◽  
P Rizk ◽  
WH Oertel ◽  
EC Hisch
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell

scholarly journals Erratum: Chen, Y.-R., et al. Improvement of Impaired Motor Functions by Human Dental Exfoliated Deciduous Teeth Stem Cell-Derived Factors in a Rat Model of Parkinson’s Disease. Int. J. Mol. Sci. 2020, 21, 3807

2021 ◽  
Vol 22 (3) ◽  
pp. 1154
Author(s):  
Yong-Ren Chen ◽  
Pei-Lun Lai ◽  
Yueh Chien ◽  
Po-Hui Lee ◽  
Ying-Hsiu Lai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Rat Model ◽  
Deciduous Teeth ◽  
Motor Functions

The authors regret to have made a mistake in publishing this paper [...]

scholarly journals Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson’s Disease

2021 ◽  
pp. 1-6
Author(s):  
Asuka Morizane ◽  
Jun Takahashi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cells ◽  
Immune Modulation ◽  
Autologous Transplantation ◽  
Human Leukocyte ◽  
Allogeneic Transplantation ◽  
Leukocyte Antigen ◽  
The Brain

Stem cell-based therapies for Parkinson’s disease are now being applied clinically. Notably, studies have shown that controlling the graft-induced immune response improves the results. In this mini-review, we concisely summarize current approaches used for this control. We focus on four modes of stem cell-based therapies: autologous transplantation, allogeneic transplantation with human leukocyte antigen-matching and allogeneic transplantation without, and finally the application of “universal” pluripotent stem cells. We also discuss immuno-suppressive treatments and the monitoring of immune reactions in the brain.

Neuroprotective effect of bone marrow derived mesenchymal stem cell secretome in 6-OHDA-induced Parkinson's disease

2021 ◽  
Author(s):  
Dhruv Mahendru ◽  
Ashish Jain ◽  
Seema Bansal ◽  
Deepti Malik ◽  
Neha Dhir ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Bone Marrow ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Neuroprotective Effect ◽  
Behavioral Parameters ◽  
Old Rats ◽  
6 Hydroxydopamine

Aim: The aim of the study was to evaluate the neuroprotective effect of bone marrow stem cell secretome in the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. Materials & methods: Secretome prepared from mesenchymal stem cells of 3-month-old rats was injected daily for 7 days between days 7 and 14 after 6-OHDA administration. After 14 days, various neurobehavioral parameters were conducted. These behavioral parameters were further correlated with biochemical and molecular findings. Results & conclusion: Impaired neurobehavioral parameters and increased inflammatory, oxidative stress and apoptotic markers in the 6-OHDA group were significantly modulated by secretome-treated rats. In conclusion, mesenchymal stem cells-derived secretome could be further explored for the management of Parkinson's disease.

scholarly journals Stem Cell Applications in Parkinson’s Disease

2017 ◽  
Vol 07 (01) ◽  
Author(s):  
Sung S Choi ◽  
Gi Hyeong Ryu ◽  
Da H Kim ◽  
Dong Seok Lee ◽  
Seunghoon Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stem Cell
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