The Effect of Probiotics or Synbiotics on the Hypertensive Disorders of Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-analysis

AbstractIntroduction:Antioxidants and anti-inflammatory drugs have been suggested to treat preeclampsia. This systematic review and meta-analysis was conducted to investigate the efficacy of probiotic or synbiotic supplementation on hypertensive disorders in women with gestational diabetes mellitus (GDM).Methods:The databases including Cochrane, Embase, Ovid, ProQuest, Scopus, Web of Science, and PubMed were systematically searched for collecting the randomized controlled trials (RCTs) investigating the efficacy of probiotic or synbiotic supplementation versus placebo on hypertensive disorders and pregnancy outcomes in GDM until July 2020.Results:Five RCTs with a total sample size of 402 women were included in the meta-analysis. There was no significant decline in systolic blood pressure (standardized mean difference [SMD] = -3.41, 95% confidence interval [CI] = -8.32 to 1.50, P = 0.17), diastolic blood pressure (SMD = -5.11, 95% CI = -14.20 to -3.98, P = 0.27), preeclampsia (odds ratio [OR] = 1.56, 95% CI = 0.61 to 3.98, P = 0.35), cesarean section (OR = 0.52, 95% CI = 0.18 to 1.50, P = 0.23), and macrosomia (OR = 0.81, 95% CI = 0.41 to 1.57, P = 0.53). No significant increase was observed in terms of 5-minute Apgar (SMD = 0.16, 95% CI = -0.06 to 0.39, P = 0.15, I2= 0%), birth weight (SMD = -0.18, 95% CI = -0.43 to 0.06, P = 0.13, I2= 0%), and gestational age (SMD = 0.13, 95% CI = -0.11 to 0.37, P = 0.28, I2= 0%).Conclusion:Probiotic or synbiotic supplements are not associated with significant effects on pregnancy outcomes in GDM. However, due to the limited number of studies in this regard and heterogeneity between studies, future high-quality RCTs are recommended.

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Effect of grape products on blood pressure: a systematic review and meta-analysis of randomized controlled trials

International Journal of Food Properties ◽

10.1080/10942912.2021.1901731 ◽

2021 ◽

Vol 24 (1) ◽

pp. 627-645

Author(s):

Omid Asbaghi ◽

Fatemeh Naeini ◽

Vihan Moodi ◽

Moein Najafi ◽

Mina Shirinbakhshmasoleh ◽

...

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled

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Re: Non-Steroidal Anti-Inflammatory Drugs for Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia: Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Journal of Urology ◽

10.1016/j.juro.2013.07.048 ◽

2013 ◽

Vol 190 (5) ◽

pp. 1819-1819

Author(s):

Steven A. Kaplan

Keyword(s):

Systematic Review ◽

Urinary Tract ◽

Lower Urinary Tract ◽

Meta Analysis ◽

Prostatic Hyperplasia ◽

Controlled Trials ◽

Randomized Controlled ◽

Urinary Tract Symptoms ◽

Inflammatory Drugs ◽

Lower Urinary

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Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials

Clinical Nutrition ◽

10.1016/j.clnu.2021.01.030 ◽

2021 ◽

Author(s):

Christina D. Filippou ◽

Costas G. Thomopoulos ◽

Maria M. Kouremeti ◽

Lida I. Sotiropoulou ◽

Petros I. Nihoyannopoulos ◽

...

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Randomized Controlled Trials ◽

Mediterranean Diet ◽

Meta Analysis ◽

Blood Pressure Reduction ◽

Controlled Trials ◽

Pressure Reduction ◽

Randomized Controlled

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Effects of cinnamon supplementation on systolic and diastolic blood pressure: a systematic review and meta-analysis of randomized controlled clinical trials

Critical Comments in Biomedicine ◽

10.18502/ccb.v2i1.5871 ◽

2021 ◽

Author(s):

Zeinab Yazdanpanah ◽

Mandana Amiri ◽

Azadeh Nadjarzadeh ◽

Hadis Hooshmandi ◽

Maryam Azadi-Yazdi

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Clinical Trials ◽

Diastolic Blood Pressure ◽

Weighted Mean Difference ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Controlled Clinical Trials ◽

Randomized Controlled Clinical Trials ◽

Randomized Controlled

Introduction: Hypertension is a chronic condition that might lead to renal and cardiovascular diseases. The previous trials examining the effect of cinnamon supplementation on blood pressure have led to conflicting results. The present systematic review aimed to summarize the effect of cinnamon supplementation on blood pressure using a meta-analysis of published randomized controlled clinical trials. Methods: To identify the eligible articles, MEDLINE, SCOPUS, ISI Web of Science, and Google Scholar were searched from inception until September 2019 for relevant articles. The risk of bias assessment was performed using the Cochrane collaboration tool. A Random-effects model was applied to calculate the summary effects. Results: Totally, 11 trials with 686 participants were included in this systematic review and meta-analysis. The dose of cinnamon supplement consumption varied from 500 to 10000 mg/d. The meta-analysis revealed that cinnamon supplementation significantly decreases systolic blood pressure (SBP) [WMD (weighted mean difference)= -5.72 mmHg, 95% confidence interval (CI): -8.63 to -2.80; P<0.001, I2= 81.1)] and diastolic blood pressure (DBP) (WMD= -4.06 mmHg, 95% CI: -6.68 to -1.44; P= 0.002, I2 = 88.6). Subgroup analysis suggested no significant reduction of DBP in subjects with diabetes (WMD= -2.015 mmHg, 95% CI: -4.55 to 0.52; P= 0.12, I2 = 72.3) and prediabetes or metabolic syndrome (WMD= -4.8 mmHg, 95% CI: -10.06 to 0.44; P= 0.073, I2= 92.5). Conclusions: Cinnamon supplementation could be beneficial in lowering SBP and DBP in adults. Further studies with different doses are recommended to conﬁrm the present findings.

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Usual dietary treatment of gestational diabetes mellitus assessed after control diet in randomized controlled trials: subanalysis of a systematic review and meta-analysis

Acta Diabetologica ◽

10.1007/s00592-018-1238-4 ◽

2018 ◽

Vol 56 (2) ◽

pp. 237-240 ◽

Cited By ~ 5

Author(s):

Apolonia García-Patterson ◽

Montserrat Balsells ◽

Jennifer M. Yamamoto ◽

Joanne E. Kellett ◽

Ivan Solà ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Control Diet ◽

Dietary Treatment ◽

Controlled Trials ◽

Randomized Controlled

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Glycemic index, glycemic load, and blood pressure: a systematic review and meta-analysis of randomized controlled trials

American Journal of Clinical Nutrition ◽

10.3945/ajcn.116.143685 ◽

2017 ◽

Vol 105 (5) ◽

pp. 1176-1190 ◽

Cited By ~ 22

Author(s):

Charlotte EL Evans ◽

Darren C Greenwood ◽

Diane E Threapleton ◽

Chris P Gale ◽

Christine L Cleghorn ◽

...

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Randomized Controlled Trials ◽

Glycemic Index ◽

Meta Analysis ◽

Glycemic Load ◽

Controlled Trials ◽

Randomized Controlled

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Cardiovascular risk factors in offspring exposed to gestational diabetes mellitus in utero: systematic review and meta-analysis

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174419000850 ◽

2020 ◽

Vol 11 (6) ◽

pp. 599-616 ◽

Cited By ~ 8

Author(s):

Maleesa M. Pathirana ◽

Zohra S. Lassi ◽

Claire T. Roberts ◽

Prabha H. Andraweera

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Systematic Review ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Systolic Blood Pressure ◽

Meta Analysis ◽

In Utero

AbstractGestational diabetes mellitus (GDM) is a pregnancy complication that affects one in seven pregnancies. Emerging evidence demonstrates that children born of pregnancies complicated by GDM may be at increased risk of cardiovascular disease (CVD) in adulthood. Therefore, the aim of this study was to determine cardiovascular risk factors in offspring exposed to GDM in utero. PubMed, CINAHL, SCOPUS, and EMBASE databases were searched. Information was extracted on established CVD risk factors including blood pressure, lipids, blood glucose, fasting insulin, body mass index (BMI), and endothelial/microvascular function. The review protocol is registered in PROSPERO (CRD42018094983). Prospective and retrospective studies comparing offspring exposed to GDM compared to controls (non-GDM pregnancies) were considered. We included studies that defined GDM based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) definition, or prior definitions. The PRISMA guidelines were followed in conducting this systematic review. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale. Study selection, data extraction, and quality assessment were done by two independent reviewers. The data were pooled using a random-effects model. Of 59 eligible studies, 24 were included in the meta-analysis. Offspring exposed to GDM had higher systolic blood pressure (mean difference (MD): 1.75 mmHg, 95% CI 0.57–2.94; eight studies, 7264 participants), BMI z-score (MD 0.11, 95% CI 0.02–0.20; nine studies, 8759 participants), and glucose (standard MD 0.43, 95% CI 0.08–0.77; 11 studies, 6423 participants) than control participants. In conclusion, offspring exposed to GDM have elevated systolic blood pressure, BMI, and glucose. Those exposed to GDM in utero may benefit from early childhood blood pressure measurements.

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