The survey of clinical manifestations of infants with cow’s milk allergy according to the COMISS questionnaire

Background: Cow’s milk is one of the first foods added to infants’ diet and cow’s milk allergy (CMA) is the most common food allergy in the first year of life. The aim of this study was to survey the frequency of infants with cow’s milk allergy using COMISS questionnaire. Methods: In a cross-sectional, descriptive study, 100 infants were selected by a convenient method. Demographic information and clinical manifestations were completed based on COMISS Questionnaire for all infants. Data were analyzed using chi-square and independent t-test. Results: The finding of this study shows that from 100 infants (51 males, 49 females), with a mean age of 3.5 ± 1.4, 61% of them were breastfed, 30% were fed both cow’s milk and breast milk, and 9% were fed only cow’s milk. The probability of cow’s milk allergy using the COMISS Questionnaire was positive in 8% of infants. According to the criteria of this Questionnaire, 65% of infants acquired a score of 0-5, 27% scored 6-11, and 8% scored 12 and above A significant association was found between cow’s milk allergy and infant’s diet (p <0.001). A significant association was also found between growth index (weight p=0.05, height p=0.02, and head circumstance p=0.03) and CMA. Conclusion: It seems that using non-invasive methods such as COMISS Questionnaire can be helpful for the diagnosis of CMA and also breastfeeding might be reducing the allergy to cow’s milk.

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The Recognition Pattern of Sequential B Cell Epitopes of Beta–Lactoglobulin Does Not Vary with the Clinical Manifestations of Cow’s Milk Allergy

International Archives of Allergy and Immunology ◽

10.1159/000024280 ◽

1999 ◽

Vol 120 (4) ◽

pp. 280-286 ◽

Cited By ~ 29

Author(s):

Andrea Heinzmann ◽

Sabine Blattmann ◽

Peter Spuergin ◽

Johannes Forster ◽

Klaus A. Deichmann

Keyword(s):

B Cell ◽

Clinical Manifestations ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

B Cell Epitopes ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Recognition Pattern ◽

Beta Lactoglobulin

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Immunopathogenesis of cow’s milk allergy

Paediatrica Indonesiana ◽

10.14238/pi43.4.2003.111-6 ◽

2016 ◽

Vol 43 (4) ◽

pp. 111

Author(s):

Ariyanto Harsono

Keyword(s):

Eating Disorders ◽

Clinical Manifestations ◽

Psychosocial Problems ◽

Final Diagnosis ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Family Disruption ◽

Cow's Milk Allergy

Given the public’s increasing awareness of cow’smilk allergy and their frequent misperception thatvarious illness is caused by cow’s milk-induced aller-gic reactions, the physician must retain some skepti-cism throughout the evaluation and rely on objectivemeasures to arrive at the final diagnosis. Over diag-nosis of cow’s milk allergy has led to malnutrition,eating disorders, and psychosocial problems, as wellas family disruption, whereas under diagnosis leavesthe patient suffering unnecessarily and may result ingrowth failure and permanent physical impairments.The following discussion provides an immunologicalbasis of cow’s milk allergy in an attempt to improveour understanding in clinical manifestations, diagno-sis and management of the disease.

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Lactose Intolerance: Common Misunderstandings

Annals of Nutrition and Metabolism ◽

10.1159/000493669 ◽

2018 ◽

Vol 73 (Suppl. 4) ◽

pp. 30-37 ◽

Cited By ~ 10

Author(s):

Margherita Di Costanzo ◽

Roberto Berni Canani

Keyword(s):

Lactose Intolerance ◽

Clinical Manifestations ◽

Gastrointestinal Symptoms ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Small Bowel Mucosa ◽

Bowel Mucosa

Lactose intolerance primarily refers to a syndrome having different symptoms upon the consumption of foods containing lactose. It is one of the most common form of food intolerance and occurs when lactase activity is reduced in the brush border of the small bowel mucosa. Individuals may be lactose intolerant to varying degrees, depending on the severity of these symptoms. When lactose is not digested, it can be fermented by gut microbiota leading to symptoms of lactose intolerance that include abdominal pain, bloating, flatulence, and diarrhea with a considerable intraindividual and interindividual variability in the severity of clinical manifestations. These gastrointestinal symptoms could be similar to cow’s milk allergy and could be wrongly labeled as symptoms of “milk allergy.” There are important differences between lactose intolerance and cow’s milk allergy; therefore, a better knowledge of these differences could limit misunderstandings in the diagnostic approach and in the management of these conditions.

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