Palm leaf catechins improved insulin-related pathways in diabetic rats

Catechin-rich oil-palm leaf extract (OPLE) (Elaeis guineensis) was previously demonstrated to possess benefits for diabetes and cardio metabolic health (vasodilation, antioxidant, cardiovascular, anti-hypertensive, anti-inflammatory, hepatoprotective and nephroprotective properties) in animal models. For insights into OPLE anti-diabetic mode-of-action and possible toxicity, the effects of dietary OPLE on insulin-signaling pathways mRNA expressions in the liver, kidney, pancreas, and spleen of normal and diabetic rats were examined. Type-2-Diabetes Mellitus (T2DM) were induced by chronic high-fat diet and streptozotocin (35 mg/kg) intraperitoneal injection. The OPLE (100 mg/kg body weight) were fed daily to normal and T2DM-induced rats. The OPLE suppressed hyperglycaemia and excessive weight gain in the T2DM rats, and appeared harmless to normal rats. The OPLE supplementation significantly (p<0.05) modulated the mRNA expressions of phosphatidylinositol-3 kinase (PIK3R1); insulin signaling receptor (INSR); insulin-receptor substrates 1 and 2; and ectonucleotide pyrophosphatase-1 (ENPP1) especially in the livers of normal rats and the spleen of diabetic rats. Results suggested the OPLE probably help prevent diabetes in healthy mammals and ameliorate the immune functions of diabetic mammals. The OPLE improved the antioxidant defence responses, insulin-pathways mRNA expressions in the normal and diabetic rats; suppressed hyperglycaemia and excessive weight gain in T2DM rodents without observable liver or kidney toxicity at the dose used.

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Preventing Excessive Weight Gain in Adolescent Girls at High Risk for Adult Obesity: Podcast

PsycEXTRA Dataset ◽

10.1037/e600722012-001 ◽

2008 ◽

Keyword(s):

Weight Gain ◽

High Risk ◽

Adolescent Girls ◽

Adult Obesity ◽

Excessive Weight Gain ◽

Excessive Weight

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The role of antenatal education for the prevention of excessive weight gain during pregnancy

Minerva Ginecologica ◽

10.23736/s0026-4784.19.04449-6 ◽

2020 ◽

Vol 71 (6) ◽

Author(s):

Roberta Amadori ◽

Carmela Melluzza ◽

Alessia Motta ◽

Alberto De Pedrini ◽

Daniela Surico

Keyword(s):

Weight Gain ◽

Excessive Weight Gain ◽

Antenatal Education ◽

Excessive Weight ◽

Weight Gain During Pregnancy

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Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0076 ◽

2020 ◽

Vol 33 (8) ◽

pp. 995-1002

Author(s):

Valeria Calcaterra ◽

Corrado Regalbuto ◽

Matteo Manuelli ◽

Catherine Klersy ◽

Gloria Pelizzo ◽

...

Keyword(s):

Celiac Disease ◽

Weight Gain ◽

Autoimmune Diseases ◽

Medical History ◽

Unknown Origin ◽

Overweight And Obesity ◽

Excessive Weight Gain ◽

Familial Predisposition ◽

Excessive Weight ◽

Hla Dq2

AbstractObjectivesThe coexistence of celiac disease (CD) and obesity/overweight is not unusual. We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain.MethodsWe enrolled 200 children referred for overweight/obesity to our outpatient clinic. Medical history during pregnancy and childhood and lifestyle variables were recorded. Patients were screened for CD with total immunoglobulin A (IgA), IgA anti-transglutaminase (tTG-IgA) and IgA anti-endomysial antibodies (EMA-IgA). In subjects with positive autoantibodies, esophagogastroduodenoscopy (EGDS) was performed and genetic testing for HLA DQ2 and/or DQ8 haplotypes was tested.ResultsCD positive antibodies (tTg-IgA and EMA-IgA) were detected in eight patients (4%); in all subjects CD diagnosis was confirmed by HLA-DQ2 and/or DQ8 compatibility and EGDS. No association between CD and medical history during pregnancy and childhood or lifestyle variables was noted; however, a dietary difference was identified with those testing positive for CD also reporting a lower weekly consumption of fruits and vegetables (p=0.04). Headache was reported more frequently in patients with than without CD (p=0.04). Familiar positivity for autoimmune diseases was revealed in CD patients (p=0.01).ConclusionCD should be considered in children with excessive weight gain. Familial predisposition to other autoimmune diseases may represent a risk factor for development of CD. Even though the relationship between headache and CD is not well defined, the patients with headache of unknown origin should be screened for CD.

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Family sociodemographic characteristics as correlates of children’s breakfast habits and weight status in eight European countries. The ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project

Public Health Nutrition ◽

10.1017/s1368980014001219 ◽

2014 ◽

Vol 18 (5) ◽

pp. 774-783 ◽

Cited By ~ 18

Author(s):

Yannis Manios ◽

George Moschonis ◽

Odysseas Androutsos ◽

Christina Filippou ◽

Wendy Van Lippevelde ◽

...

Keyword(s):

Weight Gain ◽

Energy Balance ◽

Weight Status ◽

Educational Status ◽

European Countries ◽

Sociodemographic Characteristics ◽

Excessive Weight Gain ◽

Breakfast Consumption ◽

Mediation Analyses ◽

Excessive Weight

AbstractObjectiveThe purpose of the present study was to investigate the associations of family sociodemographic characteristics with children’s weight status and whether these potential associations are mediated by children’s breakfast habits.DesignA school-based survey among 10–12-year-old children was conducted in eight European countries. Children’s weight and height were measured and breakfast habits and family sociodemographic characteristics were self-reported by 5444 children and their parents. International Obesity Task Force cut-off points were used to categorize children as overweight/obese or normal weight. Mediation analyses were used to test the potential mediating effect of children’s breakfast consumption on the associations between family sociodemographic characteristics and children’s overweight/obesity.SettingSchools in eight European countries participating in the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project.SubjectsChildren aged 10–12 years and their parents (n 5444).ResultsChildren’s reported daily breakfast consumption varied from 56 % in Slovenia to 92 % in Spain on weekdays and from 79 % in Greece to 93 % in Norway on weekends. Children of native parents, with both parents employed and with at least one parent having more than 14 years of education were more likely to consume breakfast daily and less likely to be overweight/obese. Finally, mediation analyses revealed that the association of parental nationality and parental educational status with children’s overweight/obesity was partially mediated by children’s daily breakfast consumption.ConclusionsThe study shows that the lower likelihood of being overweight/obese among 10–12-year-old children of native background and higher parental educational status was partially mediated by children’s daily breakfast consumption.

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O430 The effect of increased body mass index and excessive weight gain on success of vaginal birth after cesarean delivery

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)60803-1 ◽

2009 ◽

Vol 107 ◽

pp. S215-S215

Author(s):

G. Juhasz ◽

C. Gyamfi

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Cesarean Delivery ◽

Body Mass ◽

Vaginal Birth ◽

Vaginal Birth After Cesarean ◽

Excessive Weight Gain ◽

Excessive Weight

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Wellness and Excessive Weight Gain

Adolescent Nutrition ◽

10.1007/978-3-030-45103-5_5 ◽

2020 ◽

pp. 103-140

Author(s):

Carley MacRae

Keyword(s):

Weight Gain ◽

Excessive Weight Gain ◽

Excessive Weight

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The influence of pre-pregnancy body mass index and gestational weight gain on pregnancy outcomes in two-child women

10.21203/rs.2.16978/v1 ◽

2019 ◽

Author(s):

Hanqing Chen ◽

Suhua Zou ◽

Zhuyu Li ◽

Jianbo Yang ◽

Jian Cai ◽

...

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Gestational Weight Gain ◽

Body Mass ◽

Perinatal Outcomes ◽

Normal Weight ◽

Excessive Weight Gain ◽

Gestational Weight ◽

Excessive Weight ◽

Weight Gain During Pregnancy

Abstract Background Pre-pregnancy body mass index and gestational weight gain were related to perinatal outcomes. It was not know the changes of pre-pregnancy body mass index, weight gain during pregnancy and its effect on perinatal outcomes in two-child women.Methods This was a retrospective study. Data of single term women delivered in the First Affiliated Hospital of Sun Yat-sen University were collected from July 2017 to June 2018. Gestational weight gain criteria of the American Institute of Medical Research and pre-pregnancy body mass index classes were used to evaluate the effects on pregnancy outcomes.Results A total of 3049 cases were enrolled in the study. Overweight cases was 9.0% and obesity was 2.4%. The weight gain of the two-child women was less than that of primipara(12.4±3.9vs13.3±4.0kg, P<0.001). The proportion of primipara with excessive weight gain was higher compared to two-child women(20.1%versus17.3%, P<0.001). There were 40.0% overweight primipara and 55.2% of two-child women had excessive weight gain. And 40.5% primipara and 54.5% two-child women of obesity had excessive weight gain during pregnancy. Obese primipara increased the risk of pre-eclampsia (aOR2.38, 95%CI 0.76-7.46). And the odds of diabetes mellitus and large for gestational age also increased in this group (aOR3.49, 95%CI 1.46-8.35 and aOR7.65, 95%CI 1.83-31.97, respectively). Two-child women had similar results. Underweight primipara with excessive weight gain increased the pre-eclampsia risk (aOR2.26, 95%CI 0.29-17.46). Normal weight and overweight/obese primipara also had similar results. But in two-child women, only overweight/obesity increased the risk of pre-eclampsia (aOR2.01, 95%CI 0.41-9.98). Underweight two-child women with less weight gain increased the risk of diabetes(aOR2.06, 95%CI 0.43-9.8). Two-child women with overweight/obese increased the odds of LGA even if they had less weight gain(aOR2.58, 95%CI 0.11-63.22). Normal weight primipara and two-child women with overweight and obese with excessive weight gain had similar results. On the other way, underweight primipara with less weight gain increased the risk of SGA(aOR1.74, 95%CI 0.81-3.76).Conclusions Gestational weight gain of two-child women was less than primipara. Overweight/obese women with excessive weight gain of two-child women increased the risk of adverse outcomes.

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