The main human species mission is fertility, which is an important point of the concept of health in general and of reproductive health in particular. Endocrinologists, obstetrician-gynaecologists, urologists and paediatricians are focused in this field of medicine. A decline in male fertility of up to 30–35% results in infertility which becomes serious concerns growing for human population. Many of the problems that lead to impaired male fertility are rooted in childhood, or rather, in prenatal ontogenesis. The penetration of vascular-bed substances into the cavity of the seminiferous tubules depends on the maturity and functional status of the structures constituting the blood-testicular barrier (BTB). A breach of BTB results in damage to the sperm epithelium and, as a consequence, in different grades of impairment of spermatogenesis. Among the diseases that predispose men to infertility varicocele predominates (up to 30%). One of the reasons for infertility is the impaired integrity of BTB when the process of spermatogenesis changes, sometimes in combination with infection, trauma, and toxic effects. Given the unfavorable prognosis of the consequences of these diseases in children, their careful and timely diagnosis is important. Fertility estimation places special emphasis on the state of BTB, which can be determined by the content of claudine-11, antisperm antibodies, inhibin B, and other markers.
LECTIN-HISTOCHEMICAL REGULARITIES OF DIFFERENTIATION OF THE HUMAN PAROTID GLAND EPITHELIAL GERMS
