scholarly journals EFFECT OF CHRONIC ALCOHOLINTOXICATION AND CONSTANTLIGHTING ON CARDIOVASCULAR PARAMETERS IN MALE R

2021 ◽  
Vol 11 (1) ◽  
pp. 43-47
Author(s):  
Yuri Kirillov ◽  
Lyudmila Makartseva ◽  
Maria Kozlova ◽  
Igor Chernov ◽  
Evgeniya Shtemplevskaya ◽  
...  
Keyword(s):  
Heart Rate ◽  
Circadian Rhythms ◽  
Cardiovascular System ◽  
Alcohol Intoxication ◽  
Ethanol Exposure ◽  
Light Regime ◽  
Chronic Alcohol ◽  
Constant Illumination ◽  
Chronic Alcohol Intoxication ◽  
Combined Action

The aim of the research was to study the effect of chronic alcohol intoxication and constant il-lumination on the circadian rhythms (CR) of some parameters of the cardiovascular system in rats separately, as well as to study the rhythms of these parameters under the combined action of chronic alcohol intoxication (CAI) and constant illumination. It was found that chronic alcohol intoxication CAI at a fixed light regime causes a decrease in heart rate, an increase in SBP and PP; no changes were noted at CAI under constant lighting. At the same time, constant illumina-tion without ethanol exposure results in a decrease in heart rate and an increase in PP. At the same time, CAI with a fixed light regime leads to the destruction of CR of all parameters, except for MBP; at constant illumination with CAI no circadian rhythms of HR, DBP, PP and MBP are detected. Constant illumination leads to the destruction of the CR of PP. Among the remaining CRs, the heart rate rhythm, which is extant in the second group, persists practically unchanged, but the characteristics of all other CRs change significantly in comparison with control.

scholarly journals Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting

2021 ◽  
Vol 22 (23) ◽  
pp. 13007
Author(s):  
Maria А. Kozlova ◽  
Yuri А. Kirillov ◽  
Lyudmila А. Makartseva ◽  
Igor Chernov ◽  
David А. Areshidze
Keyword(s):  
Circadian Rhythms ◽  
Inflammatory Process ◽  
Total Bilirubin ◽  
Clock Genes ◽  
Alcohol Intoxication ◽  
Combined Effects ◽  
Chronic Alcohol ◽  
Constant Illumination ◽  
Chronic Alcohol Intoxication ◽  
Two Factors

A study of the influence of chronic alcohol intoxication, constant illumination and their combined effects on the morphofunctional state of the rat liver and the circadian rhythms (CR) of the studied parameters of the organism was carried out. It was found that both alcohol and constant illumination caused significant changes in the structure of the liver, as well as in the circadian rhythmicity of micromorphometric parameters of hepatocytes, ALT, and total and direct bilirubin rhythms; however, the combined effects of ethanol and constant illumination had the most significant effect on the studied parameters of the organism. These two factors caused disturbances in the circadian rhythms of the micromorphometric parameters of hepatocytes, disruption of the circadian rhythms of total protein, albumin, AST, ALT, and direct and total bilirubin, as well as disturbances in the expression and rhythmicity of the studied clock genes against a background of the development of an inflammatory process in the liver.

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

scholarly journals The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A

2012 ◽  
Vol 50 (4) ◽  
pp. 605-608 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Slawomir Dariusz Szajda ◽  
Magdalena Waszkiewicz ◽  
Agata Szulc ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Immunoglobulin A ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication ◽  
Salivary Immunoglobulin A

scholarly journals Nervous system injury in alcoholic disease

2019 ◽  
Vol 11 (2S) ◽  
pp. 83-88
Author(s):  
O. E. Zinovyeva ◽  
N. V. Vashchenko ◽  
O. E. Mozgovaya ◽  
T. A. Yanakaeva ◽  
A. Yu. Emelyanova
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Chronic Alcohol ◽  
Neurological Manifestations ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Disease

The paper considers various variants of nervous system injury in alcoholic disease. It discusses the epidemiology, pathogenesis, diagnosis, and clinical manifestations of central and peripheral nervous system lesions in the presence of acute and chronic alcohol intoxication. Attention is paid to the issues of etiotropic, pathogenetic, and symptomatic treatment for neurological manifestations of alcoholic disease and to the role of neurotropic B vitamins in the treatment of alcohol-induced deficiency and non-deficiency states.

scholarly journals Development of a prediabetic state under chronic alcohol intoxication

2013 ◽  
Vol 59 (4) ◽  
pp. 33-39 ◽  
Author(s):  
VV Voĭtenko ◽  
◽  
VV Konopel'niuk ◽  
OM Savchuk ◽  
LI Ostapchenko ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Prediabetic State ◽  
Chronic Alcohol Intoxication

scholarly journals The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase

2012 ◽  
Vol 50 (3) ◽  
pp. 450-455 ◽  
Author(s):  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
Sławomir Dariusz Szajda ◽  
Agata Szulc ◽  
Alina Kępka ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Chronic Alcohol Intoxication

Alcohol-induced damage to skeletal muscles in women with chronic alcohol intoxication

2021 ◽  
Vol 26 (4) ◽  
pp. 23-30
Author(s):  
N. S. Shcheglova ◽  
E. O. Zinovyeva ◽  
B. S. Shenkman
Keyword(s):  
Skeletal Muscle ◽  
Blood Plasma ◽  
Skeletal Muscles ◽  
Alcohol Intoxication ◽  
Femoral Nerve ◽  
Chronic Alcohol ◽  
Chronic Alcoholic ◽  
Chronic Alcohol Intoxication ◽  
Alcoholic Myopathy ◽  
In Blood Plasma

In Russia, there is a high level of alcohol consumption among women in doses that represent a high risk of developing alcoholic diseases, manifested, in particular, by damage to skeletal muscles.The purpose of the study. Analysis of clinical, biochemical, neurophysiological, as well as morphometric and immunohistochemical features of alcoholic skeletal muscle damage in women with chronic alcohol intoxication.Material and methods. A clinical and laboratory examination of 30 women aged 20 to 60 years with chronic alcohol intoxication was performed, which included the determination of creatine phosphokinase (CPK) and insulin-like growth factor I (IGF-I) in blood plasma, stimulation and needle electromyography (EMG), as well as morphological and immunohistochemical examination of biopsies of the quadriceps femoris.Results. Myopathic syndrome in the form of proximal para-or tetraparesis was observed in 73.3% of the examined women in combination with a decrease in IGF-1 at normal values of CPK in blood plasma. The EMG results indicated the absence of changes in the parameters of the potentials of motor units, characteristic of primary muscular lesions, and of conduction disturbances along the femoral nerve. Morphometric and immunohistochemical studies of skeletal muscle biopsies showed a decrease in the cross-sectional area of muscle fibers of types I and II without signs of muscle tissue necrosis.Conclusion. Chronic alcoholic myopathy is a common manifestation of alcoholic disease in women with long-term alcohol intoxication. The severity of the atrophic process in the skeletal muscle is comparable to the degree of proximal paresis. Violations of systemic protein synthesis and acceleration of apoptosis are considered as pathogenetic mechanisms of the atrophic process in the muscles in chronic alcoholic myopathy in women.

Age-Related Changes in the Functional Indices of Cardiac Mitochondria in Chronic Alcohol Intoxication in Rats

2019 ◽  
Vol 9 (3) ◽  
pp. 274-282
Author(s):  
T. A. Popova ◽  
I. I. Prokofiev ◽  
G. Kh. Khusainova ◽  
V. N. Perfilova ◽  
M. V. Kustova ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Chronic Alcohol ◽  
Cardiac Mitochondria ◽  
Chronic Alcohol Intoxication ◽  
Age Related ◽  
Functional Indices ◽  
Age Related Changes
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