scholarly journals Variability of the level of portal vein formation registered by computed tomography

2021 ◽  
Vol 6 (1) ◽  
pp. 4-8
Author(s):  
Aleksandr V. Kolsanov ◽  
Maksim N. Myakotnykh ◽  
Anatolii V. Tolstov ◽  
Aleksei A. Mironov
Keyword(s):  
Computed Tomography ◽  
Portal Vein ◽  
Three Dimensional ◽  
Spinal Column ◽  
Lumbar Vertebra ◽  
Thoracic Vertebra ◽  
Vein Formation ◽  
Dimensional Models ◽  
Three Dimensional Models ◽  
The Right

Objectives to study the variability of the level of portal vein formation in relation to the spinal column according to computed tomography data. Material and methods. The study evaluated the results of 100 multispiral (multislice) computed tomography (MSCT) scans of the abdominal organs done in the period of 2018-2019 and collected in the archive of the Clinics of the Samara State Medical University. For mathematical modeling and the creation of three-dimensional models of the vascular bed, we used the plug-ins in the software "Luch" and "Avtoplan" that made it possible to obtain the three-dimensional models based on MSCT data. The level of portal vein formation relative to the spinal column was studied. Results. The level of portal portal vein formation relative to the spinal column varied from the lower edge of the twelfth thoracic vertebra (ThXII) to the upper edge of the second lumbar vertebra (LII). Most often, the portal vein was formed at the level of the middle of the first thoracic vertebra body (LI). This level of portal vein formation was detected in 23% of cases. In 64% of cases, the portal vein was formed at the level of the right edge of the vertebra.

scholarly journals Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry

2021 ◽  
Vol 41 (04) ◽  
pp. 481-486
Author(s):  
Ismail Demircioglu
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Male Adult ◽  
Three Dimensional Modeling ◽  
Surface Areas ◽  
Computed Tomography Images ◽  
Significant Difference ◽  
Three Dimensional Models ◽  
The Right ◽  
Gazella Subgutturosa

The present study was conducted to identify morphometric values and to reveal differences between sexes through three-dimensional modeling of digit bones (ossa phalanges) of gazella by using computed tomography images. A total of 14 (7 female, 7 male) adult gazella (Gazella subgutturosa) cadavers were used in the study. The images were extracted by scanning acropodium bones of gazella at 64-detector Multi Detector Computed Tomography (MDCT) in cross section thickness of 0.625mm. Using MIMICS 20.1 program, three-dimensional models of these images were prepared and morphometric measurements were taken. In GLpe and Bd measurements of Phalanx proximalis, a statistically significant difference was established between females and males in terms of the left forelimb internal, the right forelimb internal, the right forelimb external, and the right hindlimb external bones (P<0.05). There was a statistically significant difference between females and males in terms of volume of phalanx proximalis and surface area of the right forelimb internal phalanx proximalis (P<0.001). In GLpe measurements, a statistically significant difference was determined between females and males in terms of the left forelimb internal, the right forelimb internal, the right hindlimb internal, the left forelimb external, the right forelimb external, and the right hindlimb external phalanx media (P<0.05). A statistically significant difference was determined between females and males in terms of the data related to volume and surface areas of the left hindlimb internal the right hindlimb internal, the left hindlimb external, and the right hindlimb external phalanx distalis (P<0.05).

Creating three dimensional models of the right ventricular outflow tract: influence of contrast, sequence, operator, and threshold

2019 ◽  
Vol 35 (11) ◽  
pp. 2067-2076
Author(s):  
Barbara E. U. Burkhardt ◽  
Nicholas K. Brown ◽  
Jaclyn E. Carberry ◽  
Marí Nieves Velasco Forte ◽  
Nicholas Byrne ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Three Dimensional ◽  
Right Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Outflow Tract ◽  
Dimensional Models ◽  
Three Dimensional Models ◽  
The Right

Plastic replicas as three-dimensional models of pulps

1975 ◽  
Vol 39 (8) ◽  
pp. 544-546
Author(s):  
HL Wakkerman ◽  
GS The ◽  
AJ Spanauf
Keyword(s):  
Three Dimensional ◽  
Dimensional Models ◽  
Three Dimensional Models

In Silico Identification and Molecular Characterization of Extracellular Cathepsin L Proteases from Giardia duodenalis

2020 ◽  
Vol 17 (4) ◽  
pp. 342-351
Author(s):  
Sergio A. Durán-Pérez ◽  
José G. Rendón-Maldonado ◽  
Lucio de Jesús Hernandez-Diaz ◽  
Annete I. Apodaca-Medina ◽  
Maribel Jiménez-Edeza ◽  
...  
Keyword(s):  
In Silico ◽  
Cathepsin L ◽  
Three Dimensional ◽  
Giardia Duodenalis ◽  
Evolutionary Genetics ◽  
Extracellular Proteins ◽  
In Silico Identification ◽  
Dimensional Models ◽  
Three Dimensional Models

Background: The protozoan Giardia duodenalis, which causes giardiasis, is an intestinal parasite that commonly affects humans, mainly pre-school children. Although there are asymptomatic cases, the main clinical features are chronic and acute diarrhea, nausea, abdominal pain, and malabsorption syndrome. Little is currently known about the virulence of the parasite, but some cases of chronic gastrointestinal alterations post-infection have been reported even when the infection was asymptomatic, suggesting that the cathepsin L proteases of the parasite may be involved in the damage at the level of the gastrointestinal mucosa. Objective: The aim of this study was the in silico identification and characterization of extracellular cathepsin L proteases in the proteome of G. duodenalis. Methods: The NP_001903 sequence of cathepsin L protease from Homo sapienswas searched against the Giardia duodenalisproteome. The subcellular localization of Giardia duodenaliscathepsin L proteases was performed in the DeepLoc-1.0 server. The construction of a phylogenetic tree of the extracellular proteins was carried out using the Molecular Evolutionary Genetics Analysis software (MEGA X). The Robetta server was used for the construction of the three-dimensional models. The search for possible inhibitors of the extracellular cathepsin L proteases of Giardia duodenaliswas performed by entering the three-dimensional structures in the FINDSITEcomb drug discovery tool. Results: Based on the amino acid sequence of cathepsin L from Homo sapiens, 8 protein sequences were identified that have in their modular structure the Pept_C1A domain characteristic of cathepsins and two of these proteins (XP_001704423 and XP_001704424) are located extracellularly. Threedimensional models were designed for both extracellular proteins and several inhibitory ligands with a score greater than 0.9 were identified. In vitrostudies are required to corroborate if these two extracellular proteins play a role in the virulence of Giardia duodenalisand to discover ligands that may be useful as therapeutic targets that interfere in the mechanism of pathogenesis generated by the parasite. Conclusion: In silicoanalysis identified two proteins in the Giardia duodenalisprotein repertoire whose characteristics allowed them to be classified as cathepsin L proteases, which may be secreted into the extracellular medium to act as virulence factors. Three-dimensional models of both proteins allowed the identification of inhibitory ligands with a high score. The results suggest that administration of those compounds might be used to block the endopeptidase activity of the extracellular cathepsin L proteases, interfering with the mechanisms of pathogenesis of the protozoan parasite Giardia duodenalis.

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