scholarly journals TRANSDERMAL FENTANYL PATCH FOR ACUTE PAIN CONTROL AFTER SHORT INTRAHOSPITAL STAY

2020 ◽  
Vol 30 (2) ◽  
pp. 114-120
Author(s):  
Matas Pažūsis ◽  
Kristijonas Jasaitis ◽  
Erika Keršytė ◽  
Andrius Macas ◽  
Žilvinas Endzinas
Keyword(s):  
Acute Pain ◽  
Pain Control ◽  
Daily Activities ◽  
Plain Language ◽  
Fentanyl Patch ◽  
Transdermal Fentanyl ◽  
On Demand ◽  
Post Operative Pain ◽  
Transdermal Fentanyl Patch ◽  
Anti Inflammatory

Transdermal fentanyl patch (TFP) is used for alleviation of chronic pain, while scientific evidence regarding its use for acute pain is insufficient. Purpose. To compare the effects of pain control by non-steroidal anti-inflammatory drug (NSAID) and TFP and the restrictions in daily activities in patients following elective minor surgical interventions. Patients and methods. Prospective, randomised, casecontrolled study included patients aged ≥18 years who underwent elective cholecystectomy, gastric fundoplication or inguinal hernia repair. All randomised patients (fentanyl prescription group, FG, and control group, CG, 62 cases each) were administered dressing plasters for the first three post-operative days; the FG patients received 50mcg/h TFP under the plaster. Within the 4 post-operative days, the patients of both groups received diclofenac on demand. Post-operative pain at rest and during movement was evaluated using the Visual Analogue Scale on the 1st, 2nd, 3rd, 4th post-operative days. Daily activities using the Functional Activity Score were scored as 0 – no limitations, 1 – some limitations, 2 – severe limitations. Results. Pain both at rest and during movement on the first three post-operative days was lower in the FG; CG patients received 5 times more doses of diclofenac on demand on the 1st day after the surgery, with the higher need of NSAID during the next two days (p<0.05). The total number of NSAID doses per patient administered on demand was 3.11±0.59 in the CG and 0.73±0.16 in the FG (p<0.05). The influence of pain on daily activities on the 2nd post-operative day was scored as 0 by 92% patients and as 1 by 8% patients of the FG, versus 60% and 40% patients of the CG (p<0.05). Conclusion. Patients with TFP experienced significantly more effective pain control leading to less restricted daily activities and used less doses of NSAID within the first few post-operative days. Plain Language Summary. Could a single long-lasting dose of transdermal fentanyl patch serve as an alternative to uncontrolled consumption of non-steroid anti-inflammatory drugs when dealing with early post-operative pain in patients following a hospital discharge after an elective minor surgery? Our conclusion suggests that the answer is “yes”, if the riskbenefits balance is evaluated.

A study of the use of a transdermal fentanyl patch in cats

1996 ◽  
Vol 32 (1) ◽  
pp. 19-24 ◽  
Author(s):  
M Scherk-Nixon
Keyword(s):  
Pain Control ◽  
Cost Effective ◽  
Therapeutic System ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl ◽  
Fentanyl Citrate ◽  
Blood Samples ◽  
Continuous Delivery ◽  
Transdermal Fentanyl Patch

A transdermal therapeutic system (TTS) has been developed for the continuous delivery of fentanyl citrate to provide ongoing analgesia in human patients with chronic pain. Several researchers believe that fentanyl transdermal patches have a place in postoperative pain control. The purpose of this study was to determine whether transdermal technology is an effective way of administering fentanyl to feline patients. Fentanyl patches were applied to the skin of six cats, and blood samples for fentanyl analysis were collected over 104 hours. This study establishes that the transdermal patch technology is an effective, long-lasting, cost-effective, noninvasive, and well-tolerated mode of deliverying fentanyl to cats.

scholarly journals Is the transdermal fentanyl patch an efficient way to achieve acute postoperative pain control?

Medicine ◽  
2018 ◽  
Vol 97 (51) ◽  
pp. e13768 ◽  
Author(s):  
Ji Su Jang ◽  
Sung Mi Hwang ◽  
Youngsuk Kwon ◽  
Hyunjin Tark ◽  
Young Joon Kim ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Control ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Acute Postoperative Pain ◽  
Transdermal Fentanyl ◽  
Transdermal Fentanyl Patch

Postoperative Pain Control with a New Transdermal Fentanyl Delivery System

1995 ◽  
Vol 83 (3) ◽  
pp. 470-477. ◽  
Author(s):  
Rafael Miguel ◽  
Joel M. Kreitzer ◽  
Douglas Reinhart ◽  
Peter S. Sebel ◽  
Julius Bowie ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Delivery System ◽  
Pain Control ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl ◽  
Placebo Patch ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background A new transdermal delivery system for fentanyl is available in two strengths: 70-80 and 90-100 micrograms.kg-1.h-1 (40- and 60-cm2 patches, respectively). Their short onset and 24-h drug delivery make them attractive for postoperative pain control. Methods Both doses of the new transdermal fentanyl patches were evaluated for the relief of postoperative pain in 143 patients after gynecologic exploratory laparotomy. The study was conducted at four centers using a prospective, randomized, placebo-controlled, double-blind format. Patients were randomly assigned to one of three study groups: group 1 patients received two placebo patches: group 2 patients received a 40-cm2 fentanyl patch and a 60-cm2 placebo patch; and group 3 patients received a 60-cm2 fentanyl patch and a 40-cm2 placebo patch. Patient-controlled morphine use and pain, sedation, and comfort scores were assessed postoperatively every 4 h for 36 h after patch placement. Results Patients' assessment of their analgesia was significantly (P &lt; or = 0.05) better in group 2 at 16 and 24 h and in group 3 at 8, 12, 16, 20, and 24 h postoperatively, compared with the patients in group 1. Patients in groups 2 and 3 required less supplemental morphine to maintain satisfactory analgesia than did the patients in group 1. Patients in groups 2 and 3 had greater incidences of pruritus, erythema, and respiratory depression than did those receiving placebo. Conclusions Concern exists regarding the side effects of this this new transdermal fentanyl patch. Therefore, this new patch will need further research before it can be recommended as an adjunct in controlling postoperative pain.

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