CONTEMPORARY UNDERSTANDING OF THE PATHOGENESIS OF RHEUMATOID ARTHRITIS.

2021 ◽  
pp. 167-172
Author(s):  
Arvinder Singh
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Synovial Membrane ◽  
Soft Tissues ◽  
Age Of Onset ◽  
Pannus Formation ◽  
Systemic Complications

Rheumatoid Arthritis (RA) is one of the most common rheumatologic conditions. Dell et al (2013) denes RA as a systemic autoimmune polyarticular arthritis, which can also have extra-articular manifestations that can lead to various systemic complications,. It is more common in women and can present at any age, however, the peak age of onset is the fth decade. RA mainly involves the synovial membrane leading to synovial inammation, proliferation, pannus formation and destruction of the articular cartilage, peri- articular bone and soft tissues.

scholarly journals Dosimetric evaluation in radiation synovectomy

2005 ◽  
Vol 48 (spe2) ◽  
pp. 153-158 ◽  
Author(s):  
Carla Flávia de Lima ◽  
Tarcisio Passos Ribeiro de Campo
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Synovial Membrane ◽  
Half Life ◽  
Three Dimensional ◽  
Low Energy ◽  
Radioactive Material ◽  
Radiation Synovectomy ◽  
Voxel Model ◽  
The Common

Rheumatoid arthritis can manifest itself through synovitis, of which the knee is the common locale. The treatment using an intra-articular radioisotope injection has been applied in various countries. In this work, the dose of radioactive material absorbed in the joint is evaluated, taking into consideration the dose received in the articular cartilage and adjacencies using a three-dimensional voxel model representing the knee. The radioisotopes studied were Samarium-153 and Dysprosium-165. The results show that the synovial membrane receives 85 to 98% of the normalized dose taken from all voxels representative of the synovium. The following features of 153Sm and of 165Dy - its short physical half-life, the gamma emissions with low energy which allow monitoring the injection trough scintigraphy images, the possibility of binding themselves to macroaggregates that are retained in the joint, the high percentage of the effective dose spread in the synovial membrane - make these suitable radioisotopes for radiation synovectomy.

scholarly journals Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

2022 ◽  
Vol 23 (2) ◽  
pp. 905
Author(s):  
Sunhee Jang ◽  
Eui-Jong Kwon ◽  
Jennifer Jooha Lee
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Autoimmune Disease ◽  
Immune Cells ◽  
Cartilage Destruction ◽  
Systemic Autoimmune Disease ◽  
Pannus Formation ◽  
Systemic Complications ◽  
Tissue Proliferation ◽  
Novel Therapeutic

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.

Infrared spectroscopic study of articular cartilage and synovial membrane

1987 ◽  
Vol 104 (5) ◽  
pp. 1535-1538
Author(s):  
S. M. Bychkov ◽  
M. M. Zakharova ◽  
S. A. Kuz'mina ◽  
V. P. Pavlov
Keyword(s):  
Articular Cartilage ◽  
Spectroscopic Study ◽  
Synovial Membrane ◽  
Infrared Spectroscopic Study ◽  
Infrared Spectroscopic

scholarly journals Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 902
Author(s):  
Susanne N. Wijesinghe ◽  
Mark A. Lindsay ◽  
Simon W. Jones
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Joint Diseases ◽  
Synovial Joint ◽  
Pharmacological Treatments ◽  
In Vivo Models ◽  
Inflammatory Joint Diseases ◽  
Joint Pathology ◽  
Cellular Pathways

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression.

Distribution of T-cell receptor-bearing lymphocytes in the synovial membrane from patients with rheumatoid arthritis

1990 ◽  
Vol 3 (6) ◽  
pp. 737-745 ◽  
Author(s):  
I CHAOUNI ◽  
M RADAL ◽  
J SIMONYLAFONTAINE ◽  
B COMBE ◽  
J SANY ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
T Cell Receptor ◽  
Synovial Membrane ◽  
Cell Receptor
Sign in / Sign up

Export Citation Format

Share Document