COMPARISON OF RETINAL NERVE FIBER LAYER THICKNESS(RNFL) IN NORMAL AND GLAUCOMA PATIENTS WITH OPTICAL COHERENCE TOMOGRAPHY(OCT)

2021 ◽  
pp. 7-8
Author(s):  
Nirav Mehta ◽  
Nayana Dhorajiya ◽  
Rupam Desai
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Glaucoma Suspect ◽  
Rnfl Thickness ◽  
Glaucoma Group

Optical coherence tomography (OCT) has proved to be valuable in the detection of glaucomatous damage. With its high resolution and proven measurement reproducibility, OCT has the potential to become an important tool for glaucoma detection. This manuscript presents the capabilities of the OCT technology evaluate retinal nerve ber layer thickness in normal and glaucoma patients Method: -A prospective, non-randomized, observational cross-sectional study was done at Rotary eye hospital, Navsari, from September 2019 to March 2020. Groups were divided in Control and glaucoma group and further Glaucoma patients were also subdivided in to Glaucoma Suspect, OHT, NTG and POAG. Patient went under comprehensive examination and selected patient went undergone measuring average retinal nerve ber layer thickness (RNFL) was by using ZEISS CIRRUS HD OCT. Results: - In overall 120 eyes of patients, 60 eyes of control group & 60 eyes of glaucoma groups were analysed. The average RNFL measurement were signicantly thinner in glaucoma group with compared control groups were 80±14 and 89±12, (P<0.01). All four quadrant RNFL thickness were analysed in Glaucoma Suspect, OHT, NTG and POAG which was statistically highly signicant. Superior quadrant RNFL thickness among groups were 105±17, 112±16, 90±17 and 85±18 m respectively (p= < 0.01).Mean RNFL thickness showed a decrease in thickness from Non-Glaucoma to Primary Open angle glaucoma (POAG) shows statistically signicant difference. Conclusions: OCT is important instrument for measuring RNFL thickness. Study shows difference in normal and glaucoma patients and different types of glaucoma patients. OCT measurement will help in early detection of glaucoma as well as in keeping an eye on progression of glaucoma.

scholarly journals Retinal Never Fiber Layer Thickness In Chronic Renal Failure: Analysis By Optical Coherence Tomography

10.3823/2557 ◽  
2018 ◽  
Vol 11 ◽  
Author(s):  
Diego Nery Benevides Gadelha ◽  
Neylane Coelho Gadelha ◽  
Orlando Vieira ◽  
Silvio De Biase Campos ◽  
Carlos Brandt
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Group Differences ◽  
Control Group ◽  
Glaucomatous Optic Neuropathy ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Retinal Nerve Fiber

Purpose: To analyze the retinal nerve fiber layer thickness (RNFL) in CKD patients by means of optical coherence tomography, ascertaining mean overall RNFL and mean RNFL in the nasal, temporal, superior, and inferior quadrants and comparing these measurements to those obtained from a control group. Methods: This was a prospective, analytical, cross-sectional case-control study. The study sample comprised 22 eyes from 11 patients and 33 eyes from 17 patients in the case and control groups respectively. RNFLT was measured with a model 3000 OCT unit (Stratus OCT-3â„¢, Carl Zeiss Meditec Inc., Dublin, CA). The fast RNFL protocol was used, which consists of three consecutive 3.4-mm-diameter circular scans centered on the optic nerve. Measured parameters included overall mean RNFL and mean RNFL at the temporal (316–45°), superior (46–135°), nasal (136–225°), and inferior (226–315°) quadrants. The Mann-Whitney U was employed to assess possible between-group differences in mean overall RNFL and RNFL at the superior, temporal, nasal, and inferior quadrants. The null hypothesis was rejected when p-values were smaller than the set significance level of <0.05. Results: Mean RNFL overall and at the superior, nasal, and inferior quadrants was greater in the control group, and that no significant between-group differences were detected in RNFL at the temporal quadrant. Conclusion: Mean retinal nerve fiber thickness was significantly lower in the group of patients with CRF than in the control group. Ischemia resulting from uremia may explain the overestimation of cases of glaucomatous optic neuropathy.   Keywords: Chronic Kidney Failure, Uremia, Optical Coherence Tomography, Retina  

Optical Coherence Tomography and Pattern Electroretinography Changes in Egyptian Patients with Major Depressive Disorder

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mostafa S ElShaarawi ◽  
Ayman A Gaafar ◽  
Hisham S. Saad Eldin ◽  
Randa H Ali
Keyword(s):  
Optical Coherence Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Major Depressive ◽  
Cross Sectional ◽  
Pattern Electroretinography

Abstract Background Major depressive disorder (MDD) is a common psychiatric disorder that affects nearly 11.1-14.6 % of the population in their lifetime. Pathophysiology and brain imaging findings show that degenerative and inflammatory processes may play a role. Meta-analysis of voxel-based morphometry studies in MDD demonstrated significant gray matter loss. From anatomical and embryological perspectives, the retina can be considered a unique extension of the brain and is able to reflect axonal histopathology. Being unmyelinated, it can provide insight into the pathophysiological processes of diseases with a neurodegenerative element. Aim to compare retinal optical coherence tomography (OCT) parameters in a group of MDD patients with a healthy control group and to correlate OCT parameters with pattern electroretinography (PERG) parameters. Method a controlled cross sectional study was conducted on 30 MDD patients and 28 age and sex matched controls. Both groups had a full ophthalmological examination, OCT imaging and 7 patients and 11 controls have PERG recorded. Results Thinning of the superior retinal nerve fiber layer, thinning of most of the ganglion cell inner plexiform (GCIP) layer, thinning of most of the macular thickness and thinning of macular volume in both eyes were detected. There was a statistically significant positive correlation between the left GCIP layer and the amplitude of the N95 wave. Also a statistically significant negative correlation existed between MDD duration in years with the left eye's average volume of the outer ring of the macula. Conclusion Significant retinal changes were detected by OCT in MDD patients supporting the theory of neurodegeneration as a pathophysiology of MDD.

scholarly journals Glaucomatous Macular Vasculature: A Quantitative Analysis

2020 ◽  
Vol 9 (3) ◽  
pp. 185-197
Author(s):  
Pedro Arede ◽  
Joanna Przezdziecka-Dolyk ◽  
Fabian Debowy ◽  
Jacek Olszewski ◽  
Carla Fernandes ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Changes ◽  
Open Angle Glaucoma ◽  
Major Axis ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Equivalent Diameter ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Avascular Zone

Background: The aim of this study was to evaluate the characteristics of the macular vessel density (VD) and the foveal avascular zone (FAZ) in glaucoma quantitatively using the optical coherence tomography angiography (OCT-A). Methods: Twenty-five eyes of 13 patients with primary open angle glaucoma (POAG) and 12 eyes of 6 healthy participants were enrolled retrospectively. Functional visual field (VF) and structural Spectral-Domain optical coherence tomography (SD-OCT) Retinal Nerve Fiber Layer Thickness (RNFLT) were assessed in all participants. OCT-A was performed on a fovea centered, 15x10 degrees, macular region. OCT-A scans were processed with MATLAB software and automatically graded to define FAZ parameters. The parafoveal VD in the superficial and deep retinal vascular plexus (SVP and DVP) was analyzed by quadrant and circular segmented zones. Results: Foveal Avascular Zone -Major Axis Length (p=0.02), Area (p=0.04), Equivalent Diameter (p=0.04) and Perimeter (p=0.04) were significantly larger in glaucoma than the control group. Regarding SVP and DVP, the average macular total VD were lower in glaucoma patients compared to the control group (p<0.01; p<0.01). Additionally, the inner circular region (p=0.04; p<0.01 respectively for SVP and DVP) and all quadrants except for North had a lower VD in glaucoma group compared to the control group. Assessment of the total VD successfully predicted RNFLT (p<0.001) and was significantly associated with the probability of glaucoma (p=0.009). Conclusion: OCT-A parameters, namely the FAZ morphology and the macular VD, were associated with glaucomatous functional and structural changes. The macular VD showed a considerable diagnostic value. It may be a modern biomarker, representing microvascular network disruption of the macular perfusion in glaucoma.

scholarly journals Assessment of retinal nerve fiber layer thickness in migraine patients measured with optical coherence tomography

2018 ◽  
Vol 5 (1) ◽  
pp. 21
Author(s):  
Alireza Khosravi ◽  
Kourosh Shahraki ◽  
Afsaneh Moghaddam
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Control Group ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Standard Value ◽  
Retinal Nerve Fiber

Background: Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in peripapillary retinal nerve fiber layer (RNFL) thickness in patients with migraine. The aim of this study was to investigate the retinal nerve fiber layer (RNFL) thickness in patients with migraine.Methods: This cross-sectional study was conducted by including thirty patients diagnosed with migraine and thirty normal individuals. Patients were evaluated in groups including migraine with and without aura and controls. Retinal nerve fiber layer (RNFL) thickness was measured using stratus optical coherence tomography (OCT) and then was compared in case and control groups. All data were analyzed using SPSS software version 16.Results: RNFL thickness was significantly thinner in migraine patients compared to the control group. Symmetricity of RNFL showed significantly reduction in patients with migraine compared to standard value (95% vs 68%). Comparison of NRR area between patients and standard value showed significantly reduced values (P=0.0001). Mean value of optic disc area showed significantly reduced value compared to standard value about 2.35 m2 (P=0.0001).Conclusions: This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms.

scholarly journals Relationship between Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry in Healthy and Glaucoma Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Beatriz Abadia ◽  
Antonio Ferreras ◽  
Pilar Calvo ◽  
Mirian Ara ◽  
Blanca Ferrandez ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Standard Automated Perimetry ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Cirrus Oct ◽  
The Relationship ◽  
Glaucoma Group

Objective. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.Methods. The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.Results. Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.;P=0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P<0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593;P<0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.Conclusions. Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.

scholarly journals Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Michael Mimouni ◽  
Hadas Stiebel-Kalish ◽  
Irena Serov ◽  
Gabriel Chodick ◽  
Mohammad Zbedat ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Open Angle Glaucoma ◽  
Youden Index ◽  
Optical Coherence ◽  
Open Angle ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Disc Area ◽  
Suprasellar Tumor

Purpose. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods. In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup/disc ratio, and rim area. Results. A total of 31 patients met the inclusion criteria and were included in the study: 16 with suprasellar tumors and 15 with POAG. Both groups were similar in terms of gender and age (P>0.05). The glaucoma group had a borderline greater total RNFL thickness (74.2 μm versus 62.8 μm, P=0.07), disc area (2.70 mm2 versus 2.16 mm2, P=0.004), and cup volume (0.20 mm3 versus 0.08 mm3, P=0.02). In multivariate, glaucoma was associated with increased total RNFL thickness (OR = 1.116 per μm, P=0.008), increased disc area (OR = 2.402 per 100 μm2, P=0.002), and decreased rim area (OR = 0.272 per 100 μm2, P=0.011). Of these, the parameter with the greatest AUC was the disc area (AUC = 0.79). Using the Youden index, the optimal cut-off point identified for stratification was a disc area greater than 2.33 μm2. Conclusions. In patients with bilateral disc cupping, a decreased total RNFL thickness and smaller disc area seem to be associated with suprasellar tumors (when compared with open-angle glaucoma). These findings may aid in early diagnosis of cupping from suprasellar tumors, before compressive visual loss occurs.

scholarly journals Retinal nerve fiber layer thickness analysis in normal, ocular hypertensive, and primary open angle glaucoma: an optical coherence tomography study

2018 ◽  
Vol 6 (4) ◽  
pp. 1304
Author(s):  
Dipak Patel ◽  
Poonam Rana ◽  
Siddharth Dua ◽  
Roshni Patel
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Optical Coherence ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness

Background: To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness in primary open angle glaucoma, ocular hypertensive and normal eyes.Methods: A 34 consecutive normal, 26 consecutive ocular hypertensives and 40 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, gonioscopy and perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide 3D 2000 TOPCON OCT. Average and segmental RNFL thickness values were compared among all groups.Results: Of the 100 eyes enrolled, the mean RNFL thickness was significantly less in glaucomatous eyes (83.165±15.938) than in normal’s (102.42±15.2) and ocular hypertensive’s (100.45±7.38). RNFL, average thicknesses in all four quadrants in POAG patients were significantly decreased compared with the OHT and the control groups.Conclusions: RNFL measurement with SD-OCT could provide important information for detection of early stages of glaucoma. (pre-perimetric glaucoma) as well as help in evaluating progression of glaucoma.

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