A CLINICOPATHOLOGICAL STUDY OF ACUTE AND CHRONIC LEUKEMIA IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 72-74
Author(s):  
Sarat Das ◽  
Prasanta Kr. Baruah ◽  
Sandeep Khakhlari ◽  
Gautam Boro
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Lymphoblastic Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Lymphoblastic Leukemia ◽  
Peripheral Blood Smear ◽  
Care Hospital ◽  
Cytochemical Study ◽  
Acute Myeloid

Introduction: Leukemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Typing of leukemia is essential for effective therapy because prognosis and survival rate are different for each type and sub-type Aims: this study was carried out to determine the frequency of acute and chronic leukemias and to evaluate their clinicopathological features. Methods: It was a hospital based cross sectional study of 60 patients carried out in the department of Pathology, JMCH, Assam over a period of one year between February 2018 and January 2019. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination (as on when available marrow sample) for morphology along with cytochemical study whenever possible. Results: In the present study, commonest leukemia was Acute myeloid leukemia (AML, 50%) followed by Acute lymphoblastic leukemia (ALL 26.6%), chronic myeloid leukemia (CML, 16.7%) and chronic lymphocytic leukemia (CLL, 6.7%). Out of total 60 cases, 36 were male and 24 were female with Male:Female ratio of 1.5:1. Acute lymphoblastic leukemia was the most common type of leukemia in the children and adolescents. Acute Myeloid leukemia was more prevalent in adults. Peripheral blood smear and bone Conclusion: marrow aspiration study still remains the important tool along with cytochemistry, immunophenotyping and cytogenetic study in the diagnosis and management of leukemia.

scholarly journals CD1d levels in peripheral blood of patients with acute myeloid leukemia and acute lymphoblastic leukemia

2014 ◽  
Vol 8 (2) ◽  
pp. 825-830 ◽  
Author(s):  
WENJIAN GUO ◽  
AISHU DONG ◽  
CHAO XING ◽  
XIAOJI LIN ◽  
XIAHUI PAN ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Lymphoblastic Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Acute Myeloid

scholarly journals A rare case of acute myeloid leukemia with ARHGEF12 (LARG, 11q23.3) and MAPRE1 (EB1, 20q11.21) fusion gene in an elderly patient

2020 ◽  
Vol 28 (1) ◽  
pp. 99-106
Author(s):  
Ioan Macarie ◽  
Florin Tripon ◽  
Bogdana Dorcioman ◽  
Melania Macarie
Keyword(s):  
Elderly Patient ◽  
Acute Myeloid Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Group Performance ◽  
Fusion Gene ◽  
Peripheral Blood Smear ◽  
Rt Pcr ◽  
Acute Myeloid

AbstractIntroduction. We report one elderly patient diagnosed with a rare subtype of acute myeloid leukemia (AML) and also with a very rare fusion gene involving ARHGEF12 (LARG, 11q23.3) and MAPRE1 (EB1, 20q11.21) genes.Material and methods. Clinical examination and routine analysis were performed including peripheral blood smear, immunophenotyping of the peripheral blood by flow cytometry and several molecular analyses.Results. Peripheral blood smear showed 80% blasts with round and some with convoluted nuclei, with basophilic cytoplasm, identified as monoblast and the majority of cells as promonocytes. Peripheral blood immunophenotyping was consistent with monocytic differentiation. Molecular analysis was negative for FLT3 ITD, FLT3 D835, NPM1, and DNMT3A R882 mutations. Multiplex ligation-dependent probe amplification revealed no copy number aberration. Ligation-dependent reverse transcription polymerase chain reaction (LD-RT-PCR) analysis identified the presence of one gene fusion between ARHGEF12 (LARG, 11q23.3) and MAPRE1 (EB1, 20q11.21) genes. The patient had no significant comorbidities, the renal function was normal and Eastern Cooperative Oncology Group performance status was 2 at diagnosis and 1 after treatment. She was treated with decitabine. She became transfusion independent and a reduction of the number of blasts was obtained.Conclusions. The outcome of our AML patient was favorable but other patients with fusion genes involving ARHGEF12 (LARG, 11q23.3) and MAPRE1 (EB1, 20q11.21) should be reported, contributing to a better characterization of the disease, to monitor the minimal residual disease and in the end to more targeted treatment options. LD-RT-PCR represent a valuable multiplex technique for fusion gene analysis.

scholarly journals Odynophagia: A Rare Presenting Symptom in Acute Myeloid Leukemia (FAB AML - M2)

2021 ◽  
Vol 6 (1) ◽  
pp. 1419-1421
Author(s):  
Sudip Yadav ◽  
Neeta Kafle ◽  
Sulav Sapkota
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Bone Marrow Examination ◽  
Solid Foods ◽  
Post Menopausal ◽  
Acute Myeloid

Acute myeloid leukemia is more common in adults than in children population. Fatigue, bleeding and fever are the most common presentations. Petechiae, gingival swelling, lymphadenopathy and hepatosplenomegaly are common signs. Here we report a case of a 57 years post-menopausal lady with gum swelling and pain on deglutition for both liquid and solid foods. She was diagnosed with a case of AML- M2 on the basis of peripheral blood smear and bone marrow examination findings.

scholarly journals Visceral leishmaniasis in acute myeloid leukemia revealed on peripheral blood smear

2018 ◽  
Vol 6 (8) ◽  
pp. 1627-1628
Author(s):  
Maxime Moniot ◽  
Maxime Loyens ◽  
Charles Mary ◽  
Coralie L’Ollivier
Keyword(s):  
Acute Myeloid Leukemia ◽  
Visceral Leishmaniasis ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Acute Myeloid

scholarly journals ultrastrutal investigation on Pseudo Chediak–Higashi abnormality in acute lymphoblastic leukemia: A case report

2021 ◽  
Author(s):  
Jing Liu ◽  
Shu-xu Dong ◽  
Ying Li ◽  
Yi-dan Xu ◽  
Yong-xin Ru
Keyword(s):  
Acute Myeloid Leukemia ◽  
Electron Microscope ◽  
Acute Lymphoblastic Leukemia ◽  
Myeloid Leukemia ◽  
Membrane Structure ◽  
Lymphoblastic Leukemia ◽  
Cytoplasmic Granules ◽  
Transmission Electron ◽  
Layer Membrane ◽  
Acute Myeloid

Pseudo Chediak-Higashi (PCH) granules are mainly common in acute myeloid leukemia. Here we found a patient diagnosed with common-B acute lymphoblastic leukemia(ALL) with PCH cytoplasmic granules, which was rarely seen in daily diagnosis. The morphology of the granules is different in transmission electron microscope (TEM) from cases reported before. There is a vesicle with various-sized particles surrounding the nucleus, in addition to the particles, a multiple-layer membrane structure was also detected in the vesicle.

Sign in / Sign up

Export Citation Format

Share Document