scholarly journals A STUDY ON IV LABETALOL VERSUS ORAL NIFEDIPINE IN ACUTE CONTROL OF SEVERE HYPERTENSION IN PREGNANCY

2020 ◽  
pp. 1-4
Author(s):  
G. Kesava Chand ◽  
Sireesha Ratal
Keyword(s):  
Blood Pressure ◽  
Severe Hypertension ◽  
Tertiary Hospital ◽  
Target Blood Pressure ◽  
10Mg Tablet ◽  
Hypertension In Pregnancy ◽  
Group 5 ◽  
Double Blinded ◽  
To Receive ◽  
In Pregnancy

Objective: To compare the efficacy of IV Labetalol with oral Nifedipine in the treatment of severe hypertension in pregnancy with blood pressure >160/110mm Hg. Methods:A parallel double blinded randomized control trial between Jan 2019 and May 2019 in 100 antenatal women of gestational age>28 weeks, admitted with blood pressure >160/110 mm Hg conducted in labour ward tertiary hospital. Antenatal women were randomized to receive oral Nifedipine 10mg tablet orally up to 5 doses and IV Labetalol was initiated at 20mg and in escalating doses of 20mg, 40mg.80mg, and 80mg up to 220mg. The number of doses and meantime taken to achieve target blood pressure <140/90 mm Hg was noted. Results:hundred antenatal women were randomized to 50 in each group.In the Labetalol group 5 patients required oral Nifedipine to achieve target blood pressure but none in the Nifedipine group. The numbers of doses required and meantime taken to achieve target bloodpressure in nefidipine group were less compared to that of Labetalol group. Conclusion: IV Labetalol and oral Nifedipine were equally effectively to achieve target blood pressure.Incomparsion, oral Nifedipine achieved target blood pressure more quickly than Labetalo

Reversed Diurnal Blood Pressure Rhythm in Hypertensive Pregnancies

1976 ◽  
Vol 51 (s3) ◽  
pp. 687s-689s ◽  
Author(s):  
C. W. G. Redman ◽  
L. J. Beilin ◽  
J. Bonnar
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Severe Hypertension ◽  
Practical Importance ◽  
Theoretical Interest ◽  
Hypotensive Drug ◽  
Pressure Pattern ◽  
Nocturnal Hypertension ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

1. Reversal of the normal diurnal blood pressure pattern has been demonstrated in women with severe hypertension and renal impairment in pregnancy (pre-eclampsia). 2. Maximum arterial pressure occurred at night in these women. The phenomenon was not due to hypotensive drug therapy or posture. Patients with uncomplicated essential hypertension in pregnancy retained a normal diurnal blood pressure pattern. 3. Nocturnal hypertension in pre-eclampsia is of theoretical interest and practical importance.

Hypertensive Disorders in Pregnancy

2017 ◽  
Author(s):  
Kavitha Vellanki ◽  
Susan Hou
Keyword(s):  
Blood Pressure ◽  
Organ Damage ◽  
The United States ◽  
Blood Pressure Target ◽  
Maternal Complications ◽  
Hypertension In Pregnancy ◽  
Hypertensive Disorders ◽  
Few Data ◽  
In Pregnancy ◽  
New Onset

Hypertensive disorders are the second leading cause of maternal mortality in the United States. Hypertension in pregnancy is defined as blood pressure greater than or equal to 140 mm Hg systolic or greater than or equal to 90 mm Hg diastolic, measured on at least two separate occasions. Preeclampsia, as per the new guidelines, is characterized by the new onset of hypertension and either proteinuria or other end-organ dysfunction, more often after 20 weeks of gestation in a previously normotensive pregnant woman. New-onset proteinuria is not required for diagnosis of preeclampsia if there is evidence of other end-organ damage—a change from previous classifications. Although no screening test has yet proven accurate enough to predict preeclampsia, the use of a combination of the serologic factors seems promising. There are few data to support any specific blood pressure target in pregnancy. Although there is a general consensus on treating severe hypertension in pregnancy, there is a difference of opinion on treating mild to moderate hypertension in pregnancy. Avoiding uteroplacental ischemia and minimizing fetal exposure to adverse effects of medications are as important as avoiding maternal complications from high blood pressure during pregnancy. This review contains 2 figures, 4 tables, and 73 references.

The renin-aldosterone system in pre-eclampsia, essential and transient hypertension during pregnancy, and normotensive pregnant and non-pregnant control subjects

1982 ◽  
Vol 101 (2) ◽  
pp. 273-280 ◽  
Author(s):  
E. B. Pedersen ◽  
A. B. Rasmussen ◽  
P. Johannesen ◽  
H. J. Kornerup ◽  
S. Kristensen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Renin ◽  
Urinary Sodium Excretion ◽  
Third Trimester ◽  
Plasma Aldosterone Concentration ◽  
The Third ◽  
Control Subjects ◽  
Hypertension In Pregnancy ◽  
Normotensive Pregnancy ◽  
In Pregnancy

Abstract. Plasma renin concentration (PRC), plasma aldosterone concentration (PAC), and blood pressure were determined in the third trimester in pregnancy, 5 days and 6 months after delivery in pre-eclampsia, essential and transient hypertension in pregnancy and in normotensive pregnant and non-pregnant control subjects. PRC and PAC were elevated several fold above non-pregnant level in all groups during pregnancy. In pre-eclampsia PRC and PAC were 220 and 160%, respectively, above the levels 6 months after delivery, and thus lower than the corresponding values, 360 and 402%, in normotensive pregnancy. In essential and transient hypertension PRC and PAC increased to the same degree as during normotensive pregnancy. Urinary sodium excretion, serum sodium and creatinine clearance were reduced in pre-eclampsia, but not in essential and transient hypertension when compared to normotensive pregnant controls. All the parameters determined were the same as in non-pregnant controls 6 months after delivery in all groups. There were no correlations between blood pressure and PRC or PAC in any of the groups neither in pregnancy nor after delivery. It is concluded that the renin-aldosterone system is stimulated in lesser degree in pre-eclampsia than in both essential hypertension, transient hypertension and normotensive pregnancy, and there was no evidence for a causal relationship between the renin-aldosterone system and blood pressure neither in normotensive nor hypertensive pregnancy.

scholarly journals Tailored physiologic treatment of severe hypertension in pregnancy: a novel approach to hypertension management

2022 ◽  
Vol 226 (1) ◽  
pp. S282
Author(s):  
Allison M. Davis ◽  
Christina T. Blanchard ◽  
Akila Subramaniam ◽  
Rachel G. Sinkey ◽  
Alan T. Tita ◽  
...  
Keyword(s):  
Severe Hypertension ◽  
Hypertension Management ◽  
Hypertension In Pregnancy ◽  
Novel Approach ◽  
In Pregnancy
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