scholarly journals Robotic Heller-Dor myotomy: 10-year monocentric experience compared with POEM

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Virginia Gallo ◽  
Jacopo Viganò ◽  
Luigi Pugliese ◽  
Raffaele Fellegara ◽  
Giuseppe Tartaglia ◽  
...  
Keyword(s):  
Invasive Procedure ◽  
Long Term Results ◽  
Esophageal Peristalsis ◽  
The Past ◽  
Endoscopic Myotomy ◽  
Dor Procedure ◽  
Esophageal Sphincter ◽  
Per Oral ◽  
Botox Injection

Achalasia is a rare motility disorder caused by an incomplete relaxation of the lower esophageal sphincter and loss of esophageal peristalsis. As a consequence, the bolus swallowing is hindered and the patients complain dysphagia, regurgitation, chest pain, respiratory symptoms and weight loss. Achalasia’s treatment has been varied over time, from therapies aiming to relax the lower sphincter of the esophagus, including drugs and Botox injection or mechanical dilatations, to surgical myotomy. Robotic or laparoscopic Heller-Dor procedure is considered the gold standard surgical treatment for symptomatic achalasia as it is proved to be effective and safe. As an alternative, Per-Oral Endoscopic Myotomy (POEM) was applied over the past decade, aiming to combine the same results of mini-invasive procedure to the advantages of endoscopic approach. In this study, we are going to compare the medium-long term results of mini-invasive Heller-Dor procedure, routinely performed in our Department, with those of POEM reported in literature.

scholarly journals Combined Replacement of Aortic Valve and Ascending Aorta—A 70-Year Evolution of Surgical Techniques

Aorta ◽  
2021 ◽  
Author(s):  
Igor Vendramin ◽  
Uberto Bortolotti ◽  
Davide Nunzio De Manna ◽  
Andrea Lechiancole ◽  
Sandro Sponga ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Elderly Patients ◽  
Aortic Valve Disease ◽  
Surgical Techniques ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Long Term Results ◽  
The Past ◽  
Technical Advances

AbstractSimultaneous replacement of the ascending aorta and aortic valve has always been a challenging procedure. Introduction of composite conduits, through various ingenious procedures and their modifications, has changed the outlook of patients with aortic valve disease and ascending aorta pathology. In the past 70 years, progress of surgical techniques and prosthetic materials has allowed such patients to undergo radical procedures providing excellent early and long-term results in both young and elderly patients. This article aims to review the most important technical advances in the treatment of aortic valve disease and ascending aorta aneurysms recognizing the important contributions in this field.

scholarly journals Evolving impact of long-term survival results on metastatic melanoma treatment

2020 ◽  
Vol 8 (2) ◽  
pp. e000948 ◽  
Author(s):  
Olivier Michielin ◽  
Michael B Atkins ◽  
Henry B Koon ◽  
Reinhard Dummer ◽  
Paolo Antonio Ascierto
Keyword(s):  
Targeted Therapies ◽  
Survival Data ◽  
Long Term Results ◽  
Tumor Type ◽  
Term Survival ◽  
Long Term Survival ◽  
The Past ◽  
Number Of Patients ◽  
Melanoma Treatment

Melanoma treatment has been revolutionized over the past decade. Long-term results with immuno-oncology (I-O) agents and targeted therapies are providing evidence of durable survival for a substantial number of patients. These results have prompted consideration of how best to define long-term benefit and cure. Now more than ever, oncologists should be aware of the long-term outcomes demonstrated with these newer agents and their relevance to treatment decision-making. As the first tumor type for which I-O agents were approved, melanoma has served as a model for other diseases. Accordingly, discussions regarding the value and impact of long-term survival data in patients with melanoma may be relevant in the future to other tumor types. Current findings indicate that, depending on the treatment, over 50% of patients with melanoma may gain durable survival benefit. The best survival outcomes are generally observed in patients with favorable prognostic factors, particularly normal baseline lactate dehydrogenase and/or a low volume of disease. Survival curves from melanoma clinical studies show a plateau at 3 to 4 years, suggesting that patients who are alive at the 3-year landmark (especially in cases in which treatment had been stopped) will likely experience prolonged cancer remission. Quality-of-life and mixture-cure modeling data, as well as metrics such as treatment-free survival, are helping to define the value of this long-term survival. In this review, we describe the current treatment landscape for melanoma and discuss the long-term survival data with immunotherapies and targeted therapies, discussing how to best evaluate the value of long-term survival. We propose that some patients might be considered functionally cured if they have responded to treatment and remained treatment-free for at least 2 years without disease progression. Finally, we consider that, while there have been major advances in the treatment of melanoma in the past decade, there remains a need to improve outcomes for the patients with melanoma who do not experience durable survival.

Sp846 Per-Oral Endoscopic Myotomy for Treatment of Hypertensive Lower Esophageal Sphincter

2011 ◽  
Vol 73 (4) ◽  
pp. AB107 ◽  
Author(s):  
Philip W.Y. Chiu ◽  
Haruhiro Inoue ◽  
Anthony Y.B. Teoh ◽  
Simon K.H. Wong ◽  
Enders K.W. Ng
Keyword(s):  
Lower Esophageal Sphincter ◽  
Hypertensive Lower Esophageal Sphincter ◽  
Per Oral Endoscopic Myotomy ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter ◽  
Per Oral

Long-term results of electrical stimulation of the lower esophageal sphincter for treatment of proximal GERD

2014 ◽  
Vol 28 (12) ◽  
pp. 3293-3301 ◽  
Author(s):  
Toshitaka Hoppo ◽  
Leonardo Rodríguez ◽  
Edy Soffer ◽  
Michael D. Crowell ◽  
Blair A. Jobe
Keyword(s):  
Electrical Stimulation ◽  
Lower Esophageal Sphincter ◽  
Long Term Results ◽  
Esophageal Sphincter ◽  
Stimulation Of

Long-term Outcomes of Per-oral Endoscopic Myotomy in Spastic Esophageal Motility Disorders

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Zaheer Nabi ◽  
Radhika Chavan ◽  
Mohan Ramchandani ◽  
Jahangeer Basha ◽  
Nitin Jagtap ◽  
...  
Keyword(s):  
Esophageal Motility ◽  
Esophageal Motility Disorders ◽  
Long Term Outcomes ◽  
Motility Disorders ◽  
Per Oral Endoscopic Myotomy ◽  
Endoscopic Myotomy ◽  
Per Oral

scholarly journals Peroral Endoscopic Myotomy for the Treatment of Achalasia: An Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Dennis Yang ◽  
Mihir S. Wagh
Keyword(s):  
Peroral Endoscopic Myotomy ◽  
Treatment Modalities ◽  
Short Term ◽  
Future Directions ◽  
Invasive Approach ◽  
Resting Pressure ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter ◽  
Low Incidence

Achalasia is a motility disorder of the esophagus, characterized by aperistalsis of the esophageal body and incomplete relaxation of the lower esophageal sphincter (LES). Treatment of achalasia is currently aimed at decreasing the resting pressure in the LES. Peroral endoscopic myotomy (POEM) is an emerging novel endoscopic procedure for the treatment of achalasia with initial data suggesting an acceptable safety profile, excellent short-term symptom resolution, low incidence of postprocedural gastroesophageal reflux (GER), and improvement in manometric outcomes. Further prospective randomized trials are required to evaluate the long-term effectiveness of this promising technique compared to other treatment modalities for achalasia. In this review we outline the technical aspects of POEM, summarize the available data on safety and outcomes, and suggest future directions for further advancement of this minimally invasive approach for the treatment of achalasia.

Life after per-oral endoscopic myotomy: long-term outcomes of quality of life and their association with Eckardt scores

2018 ◽  
Vol 87 (6) ◽  
pp. 1415-1420.e1 ◽  
Author(s):  
Yaseen B. Perbtani ◽  
Lazarus K. Mramba ◽  
Dennis Yang ◽  
Jorge Suarez ◽  
Peter V. Draganov
Keyword(s):  
Quality Of Life ◽  
Long Term Outcomes ◽  
Per Oral Endoscopic Myotomy ◽  
Endoscopic Myotomy ◽  
Per Oral

Hess. X-ray therapy for hyperthyroidism. (Strahlenther. 1937, 58, I)

1937 ◽  
Vol 33 (10) ◽  
pp. 1287-1287
Author(s):  
B. Ivanov
Keyword(s):  
Long Term Results ◽  
Graves Disease ◽  
X Ray ◽  
The Past

Author reports on the long-term results of X-ray therapy for hyperthyroidism, carried out over the past year in 140 cases. It turned out that the best results are observed with Graves' disease.

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