Spindle Cell / Sclerosing Rhabdomyosarcoma in Childhood: About A Case and Review of the Literature

Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases. Our review documents the following: sclerosing RMS occurs in both childhood and adult populations, has a predilection for the head and neck areas, and has a worse prognosis in adults. Sclerosing RMS harbors a high frequency of MYOD1 mutations, conferring a poor clinical outcome. Sclerosing RMS and spindle RMS likely represent a morphologic spectrum of one entity.

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Establishment and characterization of NCC-ssRMS2-C1: a novel patient-derived cell line of spindle cell/sclerosing rhabdomyosarcoma

Human Cell ◽

10.1007/s13577-021-00569-1 ◽

2021 ◽

Author(s):

Ryuto Tsuchiya ◽

Yuki Yoshimatsu ◽

Rei Noguchi ◽

Yooksil Sin ◽

Takuya Ono ◽

...

Keyword(s):

Cell Line ◽

Spindle Cell ◽

Sclerosing Rhabdomyosarcoma

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Fibromyxomatous spindle cell neoplasm of the ethmoid sinus with extension into the optic cavity: Report of a case and review of the literature

The Laryngoscope ◽

10.1002/lary.21326 ◽

2010 ◽

Vol 120 (S3) ◽

pp. S119-S119

Author(s):

Joshua M Levy ◽

Christian P Hasney ◽

Paul L Friedlander ◽

Michael S Ellis ◽

Mary A Fazekas-May

Keyword(s):

Spindle Cell ◽

Ethmoid Sinus ◽

Review Of The Literature ◽

Spindle Cell Neoplasm ◽

Cell Neoplasm

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Spindle Cell Lipoma Arising from the Supraglottis: A Case Report and Review of the Literature

Head and Neck Pathology ◽

10.1007/s12105-020-01259-4 ◽

2021 ◽

Author(s):

Shaghauyegh S. Azar ◽

Floyd Buen ◽

Jennifer J. Chia ◽

Yue Ma ◽

Justin Caron ◽

...

Keyword(s):

Case Report ◽

Spindle Cell ◽

Review Of The Literature ◽

Spindle Cell Lipoma

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Plexiform Neurofibroma of the Uterine Cervix: A Case Report and Review of the Literature

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-783-pnotuc ◽

2005 ◽

Vol 129 (6) ◽

pp. 783-786 ◽

Cited By ~ 2

Author(s):

Eric X. Wei ◽

Jorge Albores-Saavedra ◽

Marjorie R. Fowler

Keyword(s):

Uterine Cervix ◽

Uterine Leiomyoma ◽

Spindle Cell ◽

Plexiform Neurofibroma ◽

Fallopian Tubes ◽

Genital System ◽

Review Of The Literature ◽

Female Genital System ◽

Von Recklinghausen ◽

Female Genital

Abstract The female genital system is rarely affected in von Recklinghausen neurofibromatosis. The vulva is the most frequent genital location, but vaginal, cervical, uterine, and ovarian neurofibromas have rarely been reported. We describe a case of plexiform neurofibroma affecting the uterine cervix in a patient with chronic pelvic pain and menorrhagia who had multiple cutaneous neurofibromas and 1 large paraspinal neurofibroma. A small plexiform neurofibroma, which was not grossly visible, was confined to the uterine cervix and coexisted with a uterine leiomyoma and adenomyosis. There were no neurofibromas in the myometrium, fallopian tubes, or ovaries. Plexiform neurofibroma is a neoplasm that should be considered in the differential diagnosis of spindle cell neoplasms of the uterine cervix, especially in specimens from patients with neurofibromatosis.

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Spindle cell/sclerosing rhabdomyosarcoma with intracranial invasion without destroying the bone of the skull base: a case report and literature review

Acta Radiologica Open ◽

10.1177/2058460117727316 ◽

2017 ◽

Vol 6 (8) ◽

pp. 205846011772731

Author(s):

Daichi Momosaka ◽

Osamu Togao ◽

Akio Hiwatashi ◽

Koji Yamashita ◽

Koji Yoshimoto ◽

...

Keyword(s):

Spindle Cell ◽

Bone Destruction ◽

Japanese Woman ◽

World Health ◽

Imaging Characteristics ◽

The World ◽

Sclerosing Rhabdomyosarcoma ◽

Elderly Japanese ◽

Health Organization ◽

Worse Prognosis

Spindle cell/sclerosing rhabdomyosarcoma (ssRMS) is a new subtype of rhabdomyosarcoma included in the World Health Organization soft tissue and bone tumor classification in 2013. Despite the increasing number of reported cases of ssRMS, the imaging characteristics of ssRMS are not established. Herein, we present the case of an elderly Japanese woman with ssRMS of the masticator space with intracranial invasion without destruction of the adjacent bone. Attention should be paid to the presence of intracranial infiltration that may indicate a worse prognosis. Tumor growth without bone destruction could be a key finding to differentiate ssRMSs from conventional subtypes of rhabdomyosarcoma.

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Anaplastic Spindle Cell Squamous Carcinoma Arising from Tall Cell Variant Papillary Carcinoma of the Thyroid Gland: A Case Report and Review of the Literature

Case Reports in Endocrinology ◽

10.1155/2017/4581626 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Darren K. Patten ◽

Alia Ahmed ◽

Owain Greaves ◽

Roberto Dina ◽

Rashpal Flora ◽

...

Keyword(s):

Spindle Cell ◽

Treatment Options ◽

Squamous Carcinoma ◽

Newly Diagnosed ◽

Review Of The Literature ◽

Tall Cell Variant ◽

Aggressive Form ◽

Appropriate Treatment ◽

Tall Cell ◽

Cell Variant

Tall cell variant (TCV) of papillary thyroid carcinoma (PTC), an aggressive form of thyroid cancer, is characterised by 50% of cells with height that is three times greater than the width. Very rarely, some of these cancers can progress to spindle cell squamous carcinoma (SCSC) resulting in cancers with elements of both SCSC and TCV PTC. Here we report a case of SCSC arising from TCV PTC. In addition to this case, we have performed a literature review and compiled all published reports of SCSC arising from TCV PTC, including the nature of treatment and the prognosis for each of the 20 patients recorded. This is intended for use as a guide for clinicians in what the most appropriate treatment options may be for a newly diagnosed patient. Due to the rarity coupled with diagnosis occurring at a very advanced stage of disease progression, performing clinical trials is difficult and therefore drawing conclusions on optimal treatment methods remains a challenge.

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Solitary Fibrous Tumor of the Parapharyngeal Space: A Case Report and Review of the Literature

Ear Nose & Throat Journal ◽

10.1177/014556139607501011 ◽

1996 ◽

Vol 75 (10) ◽

pp. 681-684 ◽

Cited By ~ 15

Author(s):

Kunal Gangopadhyay ◽

Khalid Taibah ◽

M. Babu Manohar ◽

Hala Kfoury

Keyword(s):

Case Report ◽

Head And Neck ◽

Solitary Fibrous Tumor ◽

Spindle Cell ◽

Parapharyngeal Space ◽

English Literature ◽

Review Of The Literature ◽

Solitary Fibrous Tumors ◽

Rare Location ◽

Fibrous Tumor

Solitary fibrous tumors are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura. Recently, these tumors have been documented in a number of extrapleural sites including the head and neck. So far only two cases of parapharyngeal solitary fibrous tumor have been reported in the English literature. Rare location of an uncommon lesion often gives rise to difficulty in diagnosis or to misdiagnosis. In both the previously reported cases, as well as in our case, the diagnosis of solitary fibrous tumor was not made until the excised tumor was subjected to histopathology and immunohistochemistry.

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