scholarly journals MODERN CONCEPTS OF THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CHANNELS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATHOGENESIS (REVIEW)

Author(s):  
I. Yu. Sugaylo ◽  
D. E. Naumov
Physiology ◽  
2021 ◽  
Vol 36 (5) ◽  
pp. 292-306
Author(s):  
Heather A. Drummond

Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the 1) evolutionary role of these molecules in mechanosensing, 2) limitations to identifying mechanosensitive molecules, and 3) paradigm shifting molecular model for a VSMC mechanosensor.


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