scholarly journals Peptides in the composition of Laennec that show antiviral effects in the therapy of atopic dermatitis and herpes infection

2018 ◽  
Vol 15 (1) ◽  
pp. 82-90 ◽  
Author(s):  
I Yu Torshin ◽  
O A Gromova ◽  
E A Dibrova ◽  
A N Gromov ◽  
O A Nazarenko
Keyword(s):  
Atopic Dermatitis ◽  
Virus Infection ◽  
De Novo ◽  
Antiviral Effect ◽  
Viral Envelope ◽  
Herpes Infection ◽  
Antiviral Effects ◽  
Viral Particles ◽  
Peptide Composition ◽  
Infection Inhibition

A characteristic feature of atopic dermatitis is herpes infection, which necessitates application of antiviral therapy. The analysis of the peptide composition of Laennec drug by de novo mass spectrometric sequencing allowed us to identify over 10 peptides, characterized by potential antiviral effect at all stages of the viral life cycle. Laennec’s peptides can inhibit viral activation (inhibition of protein HCFC1), fusion of the viral envelope with the plasma membrane in the step of the host cell virus infection (inhibition of protein CD4), virus replication (inhibition of protein CTBP1), maturing of virion (inhibition of proteins CRM1, VPS4B, TPR, proline isomerase), budding of the viral particles from the cell membrane (inhibition of the NEDD4 protein). Laennek therapy in complex treatment of patients with atopic dermatitis and herpes virus infection can be substantiated by its pharmacologic activities including antiviral effect.

scholarly journals JNK pathway restricts DENV, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands

2020 ◽  
Author(s):  
Avisha Chowdhury ◽  
Cassandra M. Modahl ◽  
Siok Thing Tan ◽  
Benjamin Wong Wei Xiang ◽  
Dorothée Missé ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Salivary Glands ◽  
Antiviral Effect ◽  
Negative Regulator ◽  
Chikv Infection ◽  
Jnk Pathway ◽  
Antiviral Effects ◽  
Antiviral Function ◽  
Arbovirus Infection

AbstractArbovirus infection of Aedes aegypti salivary glands (SGs) determines transmission. However, there is a dearth of knowledge on SG immunity. Here, we characterized SG immune response to dengue, Zika and chikungunya viruses using high-throughput transcriptomics. The three viruses regulate components of Toll, IMD and JNK pathways. However, silencing of Toll and IMD components showed variable effects on SG infection by each virus. In contrast, regulation of JNK pathway produced consistent responses. Virus infection increased with depletion of component Kayak and decreased with depletion of negative regulator Puckered. Virus-induced JNK pathway regulates complement and apoptosis in SGs via TEP20 and Dronc, respectively. Individual and co-silencing of these genes demonstrate their antiviral effects and that both may function together. Co-silencing either TEP20 or Dronc with Puckered annihilates JNK pathway antiviral effect. We identified and characterized the broad antiviral function of JNK pathway in SGs, expanding the immune arsenal that blocks arbovirus transmission.

Prospection of the antiviral effect of bufotenine on the rabies virus infection inhibition

Toxicon ◽  
2019 ◽  
Vol 168 ◽  
pp. S39
Author(s):  
Patricia Mariano Cruz Pereira ◽  
Hugo Vigerelli De Barros ◽  
Juliana Mozer Sciani ◽  
Rita De Cássia Collaço ◽  
Thalita Rocha ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rabies Virus ◽  
Antiviral Effect ◽  
Rabies Virus Infection ◽  
Infection Inhibition

scholarly journals Antiviral Role of Phenolic Compounds against Dengue Virus: A Review

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Vanessa Loaiza-Cano ◽  
Laura Milena Monsalve-Escudero ◽  
Carlos da Silva Maia Bezerra Filho ◽  
Marlen Martinez-Gutierrez ◽  
Damião Pergentino de Sousa
Keyword(s):  
Phenolic Compounds ◽  
Dengue Virus ◽  
Biological Activities ◽  
Antiviral Effect ◽  
Health Concern ◽  
Host Proteins ◽  
Viral Particles ◽  
Antiviral Role ◽  
Productive Replication

Phenolic compounds have been related to multiple biological activities, and the antiviral effect of these compounds has been demonstrated in several viral models of public health concern. In this review, we show the antiviral role of phenolic compounds against dengue virus (DENV), the most widespread arbovirus globally that, after its re-emergence, has caused multiple epidemic outbreaks, especially in the last two years. Twenty phenolic compounds with anti-DENV activity are discussed, including the multiple mechanisms of action, such as those directed against viral particles or viral proteins, host proteins or pathways related to the productive replication viral cycle and the spread of the infection.

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