scholarly journals Oral allergenspecific immunotherapy and the way of its improvement

2009 ◽  
Vol 7 (5) ◽  
pp. 29-37
Author(s):  
L R Vykhrystsenkо
Keyword(s):  
Oral Tolerance ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Dosage Forms ◽  
Efficacy And Safety ◽  
Allergen Specific Immunotherapy ◽  
Oral Method ◽  
The Way

Oral method of allergen-specific immunotherapy (ASIT) is found to be the safe and available for the patients with allergic diseases. In this review the mechanisms of oral tolerance formation and the results of the efficacy and safety of oral ASIT are presented. The modern dosage forms of oral allergovaccines are analyzed.

Immunotheraphy in Allergic Diseases

2018 ◽  
Vol 24 (11) ◽  
pp. 1174-1194
Author(s):  
Albert Roger ◽  
Maria Basagana ◽  
Aina Teniente-Serra ◽  
Nathalie Depreux ◽  
Yanina Jurgens ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Specific Ige ◽  
World Population ◽  
Allergen Specific Immunotherapy ◽  
Routes Of Administration ◽  
Disease Modifying Therapy ◽  
History Of ◽  
Ige Mediated ◽  
Special Case

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

scholarly journals Allergen-specific immunotherapy. Analytic review of current international and Russian federal position papers

2017 ◽  
Vol 14 (1) ◽  
pp. 24-32
Author(s):  
O M Kurbacheva ◽  
K S Pavlova ◽  
M A Galitzkaya
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Allergen Specific Immunotherapy ◽  
Detailed Understanding ◽  
Analytic Review ◽  
Ige Mediated ◽  
Federal Guidelines

The article analyses the international position papers devoted to allergen-specific immunotherapy published in recent years. It also describes in details Russian federal guidelines, published in the 2013-2016 years and dedicated to allergen-specific immunotherapy as a method of treatment of IgE-mediated allergic diseases, as well as Russian federal guidelines. Detailed understanding of indications, contraindications, and usage of AIT in various clinical situations are widely discussed.

Efficacy and Safety of Allergen-Specific Immunotherapy in Rhinitis, Rhinoconjunctivitis, and Bee/Wasp Venom Allergies

2005 ◽  
Vol 24 (5-6) ◽  
pp. 519-531 ◽  
Author(s):  
G. Senti ◽  
P. Johansen ◽  
J. Martinez Gomez ◽  
B. M. Prinz Varicka ◽  
T. M. Kündig
Keyword(s):  
Specific Immunotherapy ◽  
Efficacy And Safety ◽  
Wasp Venom ◽  
Allergen Specific Immunotherapy

scholarly journals Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

2021 ◽  
Author(s):  
Ekaterina Pashkina ◽  
Veronika Evseenko ◽  
Natalya Dumchenko ◽  
Maxim Zelikman ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Side Effects ◽  
Delivery System ◽  
Glycyrrhizic Acid ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Treg Cells ◽  
Delivery Systems ◽  
New Drugs ◽  
Allergen Specific Immunotherapy

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. At the same time, it is known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, which means that in the future it can enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of supramolecular complexes (micelles) of GA with extracts of allergens seems to be very promising for the development of new drugs for AIT.

scholarly journals Standardized Quantitative Evaluation of Clinical Effectiveness and Side Effect Profile of Subcutaneous and Sublingual Allergen-Specific Immunotherapy in Children: A 5-Year Single Center Experience

2021 ◽  
Vol 19 (3) ◽  
pp. 156-165
Author(s):  
Nazan TÖKMECI ◽  
Ali DEMIRHAN ◽  
Merve TURKEGUN SENGUL ◽  
Burcu CAGLAR YUKSEK ◽  
Aylin KONT ÖZHAN ◽  
...  
Keyword(s):  
Side Effects ◽  
Allergen Immunotherapy ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Visual Analog Score ◽  
Allergen Specific Immunotherapy ◽  
Medication Score ◽  
Asthma Patients ◽  
Systemic Side Effects ◽  
High Responders

Objective: Allergen-specific immunotherapy (allergen-SIT) is a treatment method with variable efficacy in allergic diseases. This study aimed to investigate the effectiveness of allergen immunotherapy, frequency of LRs and SRs and variables affecting these parameters in patients who underwent allergen-SIT. Materials and Methods: In this study, the recorded data of 81 patients, who received subcutaneous (SCIT) or sublingual (SLIT) allergen immunotherapy for respiratory allergic diseases between 2014 and 2019, were analyzed. In asthma and/or allergic rhinoconjunctivitis (ARC) patients, the effectiveness of treatment was evaluated by analysing the change rates in disease symptom, medication and combined scores (symptom + medication) and visual analog score (VAS). Treatment success was defined by the degree of decrease in scores as; high response above 50%; low response between 20-50%; and failure <20%.Results: The mean age of allergen-SIT initiation was 11.4± 3.1 years. Diagnostic distributions of the patients were asthma (± ARC) in 64.2%, and ARC (without asthma) in 35.8%. The mode of allergen-SIT was SCIT in 77.8% (65% asthma and 35% ARC) and SLIT in 22.2% (61.1% asthma and 38.9% ARC). The main allergens used in allergen-SIT were mite (79%), grass-grain pollen (33.3%), alternaria (9.9%) and olea (8.6%). There was a significant decrease in symptoms, medication, combined and VAS scores in the asthma and ARC groups (p <0.0001), when end-SCIT values were compared to baseline. SLIT also resulted in significant decreases in these scores except asthma medication score. Among the asthma patients the rate of high-responders was 88.8% by SCIT and 50% by SLIT, according to combined asthma score. Among the ARC (without asthma) patients the rate of high-responders was 100% for both SCIT and SLIT. SCIT resulted in local (LR) and systemic side effects (SR) in 18% and 0.6% (all Grade I and Grade II) of the total injections performed. A high number of total injections was significantly associated with higher LR and SR rates. While LR was observed in 16.6% of the patients who underwent SLIT, no systemic reaction was found in any of the patients. Conclusion: SCIT was highly successful in the treatment of asthma and ARC in terms of the degree of therapeutic response. SLIT resulted in a high rate of good response in ARC patients, but a lower response degree in asthmatic patients. Systemic side effects were very low as a result of close risk monitoring and the dose adjustments performed. Keywords: Allergen-specific immunotherapy, SCIT, SLIT, efficacy, symptom score, medication score, visual analog score, side effects

scholarly journals Adenovirus-mediated Gene Therapy for Allergy

2019 ◽  
Author(s):  
Shikun Ma ◽  
Jian Guan
Keyword(s):  
Gene Therapy ◽  
Specific Immunotherapy ◽  
High Efficiency ◽  
Genetic Diseases ◽  
Experimental Studies ◽  
Modern Society ◽  
Allergic Diseases ◽  
Chronic Infections ◽  
Allergen Specific Immunotherapy ◽  
Allergy Treatment

Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment

scholarly journals Influence of sublingual allergen-specific immunotherapy on dynamics of immunological parameters in patients with pollinosis

2009 ◽  
Vol 6 (1) ◽  
pp. 39-44
Author(s):  
M V Manzhos ◽  
E S Fedenko ◽  
M A Myagkova ◽  
B A Molotilov ◽  
S A Shkadov ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Immunological Parameters ◽  
Allergen Specific Immunotherapy ◽  
Ige Antibodies ◽  
Ifn Γ ◽  
Cellular Tolerance ◽  
Th 1 ◽  
Healthy Persons ◽  
Immunologic Parameters

Background. To study the influence of sublingual allergen-specific immunotherapy (slASIT) on dynamics of immunologic parameters in patients with pollinosis. Materials and methods. 40 healthy persons and 25 pollinosis patients received slASIT course with mixt of autumn grasses allergen. IgA, IgM, IgG, IgE antibodies, slgA, albumin in saliva and IgA, IgM, IgG, IgE antibodies, total IgE, IFN-γ, IL-4 in serum were investigated. Results. Patients with pollinosis have infringements of both local and general immunity. SlASIT changes a profile of cytokines aside Th-1, stimulates formation of the secretory allergen-specific antibodies, reduces IgE antibodies in saliva. Conclusion. SlASIT is a highly effective method of allergic diseases treatment and it induces B-cellular and T-cellular tolerance.

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