MORPHOLOGICAL CHARACTERISTICS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS (ANALYSIS OF THE SURGICAL MATERIAL)

2020 ◽  
Vol 73 (11) ◽  
pp. 2339-2344
Author(s):  
Igor S. Brodetskyi ◽  
Olena O. Dyadyk ◽  
Mykhailo S. Myroshnychenko ◽  
Valentina I. Zaritska
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Tumor Tissue ◽  
Morphological Characteristics ◽  
Structural Diversity ◽  
Absolute Number ◽  
Morphological Features ◽  
Morphometric Study ◽  
Pleomorphic Adenomas ◽  
Active Processes

The aim of the study is to reveal the morphological features of pleomorphic adenomas of the salivary glands during a comprehensive examination of the surgical material. Materials and methods: Surgical material from 30 patients with pleomorphic adenomas of the salivary glands was studied. Microspecimens stained with hematoxylin and eosin were studied, using an Olympus BX-41 microscope (Japan) with subsequent processing with the Olympus DP-soft version 3.1 software, which was used to conduct a morphometric study. By morphometry in the tumor tissue, the specific volumes of the parenchyma and stroma, the thickness of the capsule located between the tumor tissue and the tissue of the salivary gland were determined; the absolute number of vessels in the field of view of the microscope was counted at × 100 magnification. Results: Comprehensive morphological analysis of the surgical material of removed neoplasms of the salivary glands has showed that mesenchymal (15 cases, 50.0%) and mixed (10 cases, 33.3%) variants of pleomorphic adenomas are more common, and less often epithelial variants (5 cases, 16.7%). Pleomorphic adenoma is characterized by a different ratio of the epithelial (parenchymal) and mesenchymal (stromal) components forming this tumor, structural diversity and heterogeneity of the structure of these components, which do not have clear boundaries and are mixed with each other. A characteristic feature of pleomorphic adenoma is also the combination in each case of different types of epithelial cells and the structures that they form, as well as areas of various differentiation of the mesenchymal component. Mesenchymal and mixed variants of pleomorphic adenomas, in comparison with the epithelial variant, are more prone to progression and recurrence, as evidenced by our identified active processes of angiogenesis in tumor tissue, frequent tumor invasion of the capsule, thinning of the capsule or the absence of the capsule, less pronounced infiltration of the capsule by immune cells. Conclusions: The morphological features of mesenchymal, mixed and epithelial variants of pleomorphic adenomas of the salivary glands revealed by the authors should be taken into account by clinicians during choosing the tactics for treating the patient, which will undoubtedly help to reduce the incidence of tumor malignization and its recurrence.

scholarly journals Canine Mammary Mixed Tumours: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Geovanni Dantas Cassali ◽  
Angélica Cavalheiro Bertagnolli ◽  
Enio Ferreira ◽  
Karine Araújo Damasceno ◽  
Conrado de Oliveira Gamba ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Factors Associated ◽  
Histological Types ◽  
Pleomorphic Adenomas ◽  
Mixed Tumours

Mammary mixed tumours are the most frequent neoplasias in female dogs. In humans, mixed tumours are frequently found in the salivary glands and are known as pleomorphic adenomas. In addition to their histomorphologic similarities, mixed tumours and pleomorphic adenomas have the potential to become malignant and give rise to carcinomas in mixed tumours and carcinomas ex-pleomorphic adenoma, respectively. The factors associated with malignant transformation are still poorly known in the case of canine mixed tumours. However, this form of neoplasia tends to be associated with a better prognosis than other malignant histological types. This paper discusses the main features associated with female canine mammary mixed tumours.

Mixed tumor of the parotid gland spreading into the cranial cavity

2017 ◽  
Vol 6 (1) ◽  
pp. 21-25
Author(s):  
Daniel Majszyk ◽  
Ewa Osuch-Wójcikiewicz ◽  
Małgorzata Czesak ◽  
Kazimierz Niemczyk
Keyword(s):  
Parotid Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Tumor Tissue ◽  
Benign Tumor ◽  
Mixed Tumor ◽  
Cranial Cavity

Pleomorphic adenoma is benign tumor of the salivary glands. It is the most common neoplasm occurring in salivary glands. Although it is a benign tumor, it should be treated as a clinically uncertain. In about half of the cases a blurred boundary between the tumor tissue and the parotid parenchyma can be observed. This tumor metastasize distant, even without malignant transformation. Malignant transformation of adenoma observed in 3-5% of cases. The aim of this study was to present the case of 75-year-old patient with recurrent mixed tumor spreading by continuity to the cranial cavity.

Heterotopic pleomorphic adenoma of the external nose

1996 ◽  
Vol 110 (4) ◽  
pp. 376-378 ◽  
Author(s):  
Lydia Badia ◽  
Justin N. Weir ◽  
Anthony C. Robinson
Keyword(s):  
Salivary Gland ◽  
Nasal Cavity ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Subcutaneous Tissue ◽  
Minor Salivary Glands ◽  
Salivary Gland Tumours ◽  
External Nose ◽  
Pleomorphic Adenomas ◽  
The Right

AbstractPleomorphic adenomas arising from sites other than the major or minor salivary glands are uncommon. We describe a case of pleomorphic adenoma in the subcutaneous tissue of the nasomaxillary crease. An identical tumour was previously excised from the right nasal cavity. The possible aetiology of these heterotopic salivary gland tumours is discussed.

scholarly journals Clinical Presentation and Histological Variation of Pleomorphic Adenoma of Salivary Glands

2019 ◽  
Vol 37 (2) ◽  
pp. 72-77
Author(s):  
Md Nazmul Hasan Khandker ◽  
SM Anwar Sadat ◽  
Tarin Rahman ◽  
Ismat Ara Haider ◽  
Mohiuddin Ahmed
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Clinical Presentation ◽  
Maxillofacial Surgery ◽  
Mouth Opening ◽  
Morphological Characteristics ◽  
Salivary Gland Tumour ◽  
Frequent Pattern ◽  
Gland Tumour

Background: Pleomorphic Adenoma is the most common salivary gland tumour accounts 40-70% of all salivary gland tumour and about 60-80% of the benign tumours and 60- 70% of all parotid tumours. There is no study conducted in Bangladesh to observe the clinical and histological variation of the tumour. This study presents 36 cases of Pleomorphic adenoma collected over 11 months at the different territory hospital of Dhaka city. Design: Observational study (November’ 2011 to September’ 2012) Setting: Department of Oral and Maxillofacial Surgery (Dhaka Dental College and Hospital, Bangabandhu Sheikh Mujib Medical Universityl), Department of ENT and Head- Neck Surgery (Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University). Method: The entire patient clinically and cytologically diagnosed as Pleomorphic adenoma were selected. Data were collected in a summarized data sheet. Then histopathological types of them were analyzed from excisional biopsized tissue. Result: There were 36 patients of Pleomorphic adenoma of which 24(66.67%) in Parotid glands, 4(11.11%) in Submandibular glands and 8(22.22%) in minor salivary glands. Among the respondents, female was predominant 20(55.56%) with ages were between 29 years to 65 years old (mean age 44.83 ± 8.32 years) with most patients (44.44%) in 41 to 50 years of life. In histophathological study showed Stromal rich 38.89%, cell rich 36.11% and classic 25%. Cuboidal cells were the most commonly found cellular type followed by plasmacytoid and spindle.Trabeculae and duct like structures were the most frequent pattern by the epithelial cells.Myxoid and Hyalinization were the most frequently found mesenchymal like tissue.Cases presented with symptoms such as swelling (100%), limitation of mouth opening, paesthesia and pain. Conclusion: The knowledge about clinical presentation and the immense variety of cells, architectures and morphological characteristics present in Pleomorphic adenoma of the salivary gland is essential for correct diagnosis and prognosis. The need for improved diagnostic facilities and upgrading of infrastructure was stressed. J Bangladesh Coll Phys Surg 2019; 37(2): 72-77

scholarly journals TUMORS AND TUMOR-LIKE LESIONS OF THE SALIVARY GLANDS: MORPHOLOGICAL CHARACTERISTICS OF THE SURGICAL MATERIAL

2021 ◽  
Vol 74 (4) ◽  
pp. 929-933
Author(s):  
Igor S. Brodetskyi ◽  
Vladislav A. Malanchuk ◽  
Bogdan V. Sorokin ◽  
Mykhailo S. Myroshnychenko ◽  
Yuliya I. Beketova ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Connective Tissue ◽  
Salivary Glands ◽  
Tumor Invasion ◽  
Genetic Research ◽  
Morphological Characteristics ◽  
Benign Tumors ◽  
Clinical Hospital ◽  
Pleomorphic Adenomas ◽  
Tumor Like Lesions

The aim is to give a morphological characteristic of tumors and tumor-like lesions of the salivary glands in the course of a comprehensive analysis of the surgical material. Materials and methods: The study used surgical material from 67 patients with various pathologies of the salivary glands. The patients were treated at Kyiv City Clinical Hospital No. 12 (Ukraine, Kiev) from 2014 to 2018. The resulting material was fixed in a 10% solution of neutral formalin (pH 7.4) for 24-48 hours, carried out according to the generally accepted technique and embedded in paraffin. Serial sections 2 μm thick were made from paraffin blocks and stained with hematoxylin and eosin. Microspecimens were studied, using Olympus BX-41 microscope (Japan). Results: A comprehensive morphological study of the surgical material of patients with salivary gland pathology undergoing treatment at Kyiv City Clinical Hospital No. 12 (Ukraine, Kiev) for the period from 2014 to 2018 revealed benign tumors and tumor-like lesions of these glands. Pleomorphic adenomas and adenolymphomas represented benign tumors of the salivary glands, while cysts represented tumor-like lesions. Different ratios of parenchymal and stromal components characterized pleomorphic adenomas of the salivary glands. On this basis, we identified three tumor variants (mesenchymal (15 cases, 50.0 %); mixed or classic (10 cases, 33.3 %); epithelial (5 cases, 16.7 %)). A characteristic microscopic feature of salivary gland adenolymphomas was a pronounced predominance of the parenchyma over the stroma. A well-defined wall, represented by connective tissue fibers and epithelial lining, characterized the cysts of the salivary glands. The connective tissue capsule separating the tumor tissue from the intact tissue of the salivary gland was clearly pronounced in adenolymphomas, and in pleomorphic adenomas it could be clearly expressed, intact, with tumor invasion or absent. In mesenchymal and mixed variants of pleomorphic adenomas, in comparison with the epithelial variant, there was a frequent tumor invasion of the capsule, thinning of the capsule or its absence. Conclusions: Morphological examination of the surgical material allows us to diagnose tumors (pleomorphic adenomas and adenolymphomas) and non-tumor lesions (cysts) of the salivary glands. This, of course, is of great therapeutic, diagnostic and prognostic value. Among the identified pathology of the salivary glands, pleomorphic adenomas cause certain difficulties in morphological diagnosis due to their structural diversity and heterogeneity, sometimes requiring morphometric, immunohistochemical or genetic research.

scholarly journals USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS

2020 ◽  
Vol 20 (1) ◽  
pp. 149-154
Author(s):  
I. S. Brodetskyi ◽  
V.A. Malanchuk ◽  
V. E Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Micro Rna ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue ◽  
Benign Tumours

Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood.  Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time. Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue). Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.

Pleomorphic Adenoma of Palate – A Case Report and Review of Literature

2020 ◽  
Author(s):  
Sameer Kaura
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Minor Salivary Gland ◽  
Surgical Excision ◽  
Review Of Literature ◽  
Common Site ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
Risk Of Malignancy ◽  
History Of

10% of pleomorphic adenomas occur in the minor salivary glands with the palate being the most common site. Pleomorphic adenomas account for the majority of palatal tumours; however, minor salivary gland tumours have a higher risk of malignancy compared to tumours of the major salivary glands, so definite diagnostic evaluation should be executed. A case of 26-year-old man with a longstanding history of a soft palate pleomorphic adenoma which required excision under general anaesthetia We discuss the appropriate preoperative investigations, operative technique for surgical excision, histopathologic interpretation for this patient and brief review of literature for pleomorphic adenoma.

scholarly journals Pleomorphic adenoma of the nasal cavity- an unusual presentation

2016 ◽  
Vol 3 (1) ◽  
pp. 162
Author(s):  
Archana Arora ◽  
Karan Sharma
Keyword(s):  
Nasal Cavity ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Nasal Septum ◽  
Histopathological Examination ◽  
Computed Tomographic ◽  
Common Benign Tumor ◽  
Pleomorphic Adenomas ◽  
History Of ◽  
The Right

<p class="abstract">Pleomorphic adenomas (mixed tumors) are the most common benign tumor of the major salivary glands. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual. We report a rare case of large sized pleomorphic adenoma arising from the nasal septum. A 42-year-old man presented with a 3 month history of multiple episodes of nasal bleeding and obstruction on right side of nose. On examination we found a non-tender firm mass extending upto the nasal vestibule which bled on probing. Computed tomographic scans revealed a mass in the right anterior nasal cavity and spur on left side. Paranasal sinuses, posterior choanae and nasopharynx were normal. An intranasal endoscopic approach was used to achieve a wide local resection along with coagulation of base and spurectomy on the left side. The mass was 2.5×2.0 cm with a broad based attachement of 1.0 cm on the nasal septum. The microscopic finding showed a lobular and duct-like structures consisting of a loose chondromyxoid stroma suggestive of a pleomorphic adenoma. Large sized nasal cavity mass with history of epistaxis and which bleeds on probing should be finally assessed under general anaesthesia. It should be excised endoscopically and subjected to histopathological examination<span lang="EN-IN">.</span></p>

Carcinoma arising in a pleomorphic adenoma of the epiglottis

1989 ◽  
Vol 103 (3) ◽  
pp. 324-327 ◽  
Author(s):  
C. A. Milford ◽  
T. A. Mugliston ◽  
P. O'Flynn ◽  
K. McCarthy
Keyword(s):  
Salivary Glands ◽  
Neck Dissection ◽  
Pleomorphic Adenoma ◽  
Partial Laryngectomy ◽  
Minor Salivary Glands ◽  
Rare Tumour ◽  
Pleomorphic Adenomas ◽  
Functional Neck Dissection ◽  
One Year ◽  
Mixed Tumours

AbstractDespite the abundance of minor salivary glands within the larynx, pleomorphic adenomas are rarely found. It is therefore not surprising that there are few reports of malignant mixed tumours in this site. We describe a case of carcinoma arising in a pleomorphic adenoma of the epiglottis which, to our knowledge, has not been described previously.The patient underwent a horizontal partial laryngectomy and functional neck dissection and is well one year post-operatively. We feel this represents a suitable approach to treatment for this rare tumour.

Pleomorphic Adenoma of the Nasal Septum

2014 ◽  
Vol 6 (1) ◽  
pp. 10-12
Author(s):  
Thakur Rahul Tejendrasingh ◽  
Sonawale Sanjay Kumar Laxmanrao
Keyword(s):  
Parotid Gland ◽  
Nasal Cavity ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Soft Palate ◽  
Nasal Septum ◽  
Benign Tumor ◽  
Minor Salivary Glands ◽  
Common Benign Tumor ◽  
Pleomorphic Adenomas

ABSTRACT Pleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum.

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