Clinical Presentation and Histological Variation of Pleomorphic Adenoma of Salivary Glands

Background: Pleomorphic Adenoma is the most common salivary gland tumour accounts 40-70% of all salivary gland tumour and about 60-80% of the benign tumours and 60- 70% of all parotid tumours. There is no study conducted in Bangladesh to observe the clinical and histological variation of the tumour. This study presents 36 cases of Pleomorphic adenoma collected over 11 months at the different territory hospital of Dhaka city. Design: Observational study (November’ 2011 to September’ 2012) Setting: Department of Oral and Maxillofacial Surgery (Dhaka Dental College and Hospital, Bangabandhu Sheikh Mujib Medical Universityl), Department of ENT and Head- Neck Surgery (Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University). Method: The entire patient clinically and cytologically diagnosed as Pleomorphic adenoma were selected. Data were collected in a summarized data sheet. Then histopathological types of them were analyzed from excisional biopsized tissue. Result: There were 36 patients of Pleomorphic adenoma of which 24(66.67%) in Parotid glands, 4(11.11%) in Submandibular glands and 8(22.22%) in minor salivary glands. Among the respondents, female was predominant 20(55.56%) with ages were between 29 years to 65 years old (mean age 44.83 ± 8.32 years) with most patients (44.44%) in 41 to 50 years of life. In histophathological study showed Stromal rich 38.89%, cell rich 36.11% and classic 25%. Cuboidal cells were the most commonly found cellular type followed by plasmacytoid and spindle.Trabeculae and duct like structures were the most frequent pattern by the epithelial cells.Myxoid and Hyalinization were the most frequently found mesenchymal like tissue.Cases presented with symptoms such as swelling (100%), limitation of mouth opening, paesthesia and pain. Conclusion: The knowledge about clinical presentation and the immense variety of cells, architectures and morphological characteristics present in Pleomorphic adenoma of the salivary gland is essential for correct diagnosis and prognosis. The need for improved diagnostic facilities and upgrading of infrastructure was stressed. J Bangladesh Coll Phys Surg 2019; 37(2): 72-77

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Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

The International Journal of Biological Markers ◽

10.5301/jbm.2012.10373 ◽

2012 ◽

Vol 27 (4) ◽

pp. 381-388 ◽

Cited By ~ 5

Author(s):

Mark R. Darling ◽

Nelly N. Hashem ◽

Irene Zhang ◽

Mohamed Mohamed ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Tumour ◽

Immunoperoxidase Staining ◽

Aberrant Expression ◽

Adenoid Cystic ◽

Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges

Case Reports in Dentistry ◽

10.1155/2017/5741821 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Rammohan Kumar ◽

Srikant Natarajan ◽

K.S. Sneha ◽

Nunna Sai Chitra ◽

Karen Boaz ◽

...

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Good Prognosis ◽

Salivary Gland Tumour ◽

Diagnostic Workup ◽

Low Grade ◽

Minor Salivary Glands ◽

Gland Tumour

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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A clinical study of the incidence of salivary gland tumors in a tertiary care teaching hospital

International Surgery Journal ◽

10.18203/2349-2902.isj20192376 ◽

2019 ◽

Vol 6 (6) ◽

pp. 2110

Author(s):

Sathish Babu N. ◽

Naveen H. Mahadev ◽

Kumar G. V.

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Critical Role ◽

Tertiary Care ◽

Malignant Neoplasm ◽

Salivary Gland Tumour ◽

Major Salivary Gland ◽

Salivary Gland Tumours ◽

Gland Tumour

Background: The salivary gland system of the upper aero digestive tract plays a critical role in the functions of digestion, respiration, communication, and overall homeostasis. The Salivary gland swellings can be broadly classified into inflammatory, non-inflammatory and neoplastic swellings like calculi, benign tumours such has pleomorphic adenoma, oncocytoma, Warthin's tumour, malignant tumors which include-adenocarcinoma, adenoid cystic carcinoma, undifferentiated carcinoma.Methods: The present cross-sectional study was conducted at the Department of general surgery, Sri Siddhartha Medical College over a period of 2 years from August 2016 to July 2018. All major salivary gland neoplastic swellings confirmed by FNAC were included in this study.Results: In our study 23 patients had major salivary gland tumours out of that 19 patients had parotid and 4 had submandibular major salivary gland tumour. In our study out 23 cases of salivary tumours 19 cases were benign and 4 cases were malignant, out of 19 cases of parotid tumours, 15 (78.94%) cases were seen in superficial lobe and 4 (21.06%) were in deep lobe, out of 23 salivary gland tumours, 19 (82.6%) cases were pleomorphic adenoma 3(13.05%) cases were mucoepidermoid carcinoma and one case (4.35%) was acinic cell carcinoma.Conclusions: Parotid gland was the most common site of origin of both benign and malignant tumours, Pleomorphic adenoma was the most common benign salivary gland tumour and mucoepidermoid carcinoma was the most frequent malignant neoplasm.

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Congenital pleomorphic adenoma of the nasopharynx

The Journal of Laryngology & Otology ◽

10.1017/s0022215100098546 ◽

1985 ◽

Vol 99 (12) ◽

pp. 1281-1287 ◽

Cited By ~ 19

Author(s):

Gady Har-El ◽

Howard Y. Zirkin ◽

Ferit Tovi ◽

Jack Sidi

Keyword(s):

Salivary Gland ◽

Head And Neck ◽

Pleomorphic Adenoma ◽

Histological Type ◽

Salivary Gland Tumour ◽

Congenital Tumours ◽

Gland Tumour

AbstractA case of congenital salivary gland tumour occurring in the nasopharynx is reported. Congenital neoplasms of the head and neck (of any histological type) and congenital tumours of the nasopharynx are discussed and the literature is reviewed.

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Salivary gland tumours: a hospital-based study on demographic and incidence pattern, histopathological types and treatment strategy

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20205062 ◽

2020 ◽

Vol 6 (12) ◽

pp. 2218

Author(s):

M. K. Mili ◽

Hirak Jyoti Das ◽

Asha Saikia ◽

N. J. Saikia ◽

J. Phookan ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Treatment Strategy ◽

Tertiary Care ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Female Ratio ◽

Salivary Gland Tumours ◽

Gland Tumour

Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Out of 21 cases, 14 were parotid gland tumours, 6 submandibular gland tumours and 1 minor salivary gland tumour. Most of the tumours were benign (16) and 5 were malignant.Conclusions: Two patients were of age 19 years which is conflicting the normal national incidence. All cases belonged to lower economic strata with decreased intake of beta carotene enriched food items. The most common site is parotid gland and most common tumour is pleomorphic adenoma which is in accordance to other studies. Benign cases were subjected to superficial parotidectomy and malignant cases to total parotidectomy with neck dissection.

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O.139 Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumour-pleomorphic adenoma

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/s1010-5182(06)60168-6 ◽

2006 ◽

Vol 34 ◽

pp. 39-40

Author(s):

O. Emodi ◽

I. Abu El Naaj ◽

A. Gordin ◽

M. Peled

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Salivary Gland Tumour ◽

Superficial Parotidectomy ◽

Gland Tumour

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Salivary gland tumour: pleomorphic adenoma and morphological variants – great pretender

Pathology ◽

10.1097/01.pat.0000426761.60334.bf ◽

2013 ◽

Vol 45 ◽

pp. S10-S11

Author(s):

Alfred Lam

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Salivary Gland Tumour ◽

Morphological Variants ◽

Gland Tumour

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Clinicopathological study of minor salivary gland tumour

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v17i1.7628 ◽

1970 ◽

Vol 17 (1) ◽

pp. 48-52

Author(s):

Md Shazibur Rashid ◽

Mohammad Ashequr Rahman Bhuiyan ◽

Mohammad Shafiqul Islam ◽

Belayat Hossain Siddiquee

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Hard Palate ◽

Minor Salivary Gland ◽

Malignant Tumour ◽

Histological Type ◽

Salivary Gland Tumour ◽

Salivary Gland Neoplasm ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Objectives: To find out the clinicopathological factors of minor salivary gland tumour. Methods: An attempt has been made to explore the relative incidence, clinical presentation, age and sex distribution, histological type, site of involvement of each cases of minor salivary gland tumour. Thirty cases of minor salivary gland tumours were studied. Sampling method was purposive, convenient. Data were collected in a prescribed data sheet from BSMMU, DMCH and BKZMC and SSH, Dhaka, during the period of October 2006 to May 2007. Results: In this series of 30 patients, 20 cases (67%) were found malignant and 10 cases (33%) were benign. Regarding the site of distribution of minor salivary gland tumour, 67% (20) were found in the hard palate, three patients were found in the soft palate, three patients in the check, two in the nasopharynx and two in the alveolar margin. All benign tumours in this series were pleomorphic adenoma. Monomorphic adenoma was not found in any patients. Among malignant tumour adenoid cystic carcinoma was the most common 70% (14). Pleomorphic adenoma was found in 33% (10) of total cases. Muco-epidermoid carcinoma was the 2nd most common malignant tumour 12.5% (4). Carcinoma in pleomorphic adenoma was the least common histological type 6% (2). Conclusion: Early diagnosis and treatment of minor salivary gland tumour is likely to lead to a fair outcome. All patients with swelling in hard palate should be considered as a minor salivary tumour. Sub clinical lymphatic metastasis may occur in malignant cases, so all patients should be referred for radiotherapy following surgery. Distant metastases are also rare in such type of malignancy. Key words: Minor salivary gland; Neoplasm. DOI: 10.3329/bjo.v17i1.7628 Bangladesh J Otorhinolaryngol 2011; 17(1): 48-52

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Schwannoma-like pleomorphic adenoma of the parotid

Rare Tumors ◽

10.4081/rt.2011.e40 ◽

2011 ◽

Vol 3 (4) ◽

pp. 126-128 ◽

Cited By ~ 4

Author(s):

Jean-Christophe Tille ◽

Hervé Reychler ◽

Marc Hamoir ◽

Sandra Schmitz ◽

Birgit Weynand

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Rare Case ◽

Salivary Gland Tumour ◽

Frequent Finding ◽

Chondroid Metaplasia ◽

Gland Tumour

Pleomorphic adenoma is the most common benign salivary gland tumour. It can occur in any salivary gland, but is most frequently found in the parotid gland. Chondroid metaplasia is a frequent finding in pleomorphic adenoma. Other forms of metaplasia have been described, but are encountered less frequently. We report a rare case of unusual pleomorphic adenoma of the parotid gland with schwannoma-like feature.

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