scholarly journals Evaluation of Total Error and Validation of Reference Value on Hematology Analyzer

2021 ◽  
Vol 8 (1) ◽  
pp. 37-46
Author(s):  
Zulfikar Husni Faruq
Keyword(s):  
Mean Platelet Volume ◽  
Total Error ◽  
Reference Value ◽  
Small Sample ◽  
Platelet Volume ◽  
Hematology Analyzer

Pemeriksaan darah lengkap merupakan pemeriksaan screening atau merupakan uji saring sebagai pintu awal diagnosis sehingga dibutuhkan peralatan yang baik dan berkulitas. Penelitian ini bertujuan untuk Mengevaluasi Total Error dan Nilai Rujukan Hematology Analyzer. Pengukuran Total Eror (TE) dilakukan dengan menggunakan bahan kontrol komersial yang sudah diketahui konsentrasinya dan dilakukan pengambilan data sebanyak 20 data dengan menggunakan metode day to day kemudian dihitung menggunakan rumus Total Error (TE). Evaluasi nilai rujukan dilakukan menggunakan metode validasi nilai rujukan dengan sampel kecil (small sample) menggunakan sampel darah K2EDTA sebanyak 22 sampel laki laki dewasa dan 22 Wanita Dewasa sehat dan tidak dalam keadaan hamil. Dari hasil penelitian ini diketahui bahwa nilai Total Error (TE) memiliki nilai terbesar adalah pada parameter trombosit dan Mean Platelet Volume (MPV). Untuk hasil evaluasi nilai rujukan pada alat untuk laki laki dewasa yang belum disetujui adalah pada parameter WBC, HCT, MCV, RDW, RDW-SD dan MPV. Sedangkan parameter yang belum disetujui untuk nilai rujukan wanita dewasa adalah MCH, RDW-SD dan MPV.

scholarly journals The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Pattraporn Tajarernmuang ◽  
Arintaya Phrommintikul ◽  
Atikun Limsukon ◽  
Chaicharn Pothirat ◽  
Kaweesak Chittawatanarat
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Mean Platelet Volume ◽  
Meta Analysis ◽  
Small Sample ◽  
Mean Difference ◽  
Platelet Volume ◽  
Significant Difference ◽  
The Mean

Background. An increase in the mean platelet volume (MPV) has been proposed as a novel prognostic indicator in critically ill patients.Objective. We conducted a systematic review and meta-analysis to determine whether there is an association between MPV and mortality in critically ill patients.Methods. We did electronic search in Medline, Scopus, and Embase up to November 2015.Results. Eleven observational studies, involving 3724 patients, were included. The values of initial MPV in nonsurvivors and survivors were not different, with the mean difference with 95% confident interval (95% CI) being 0.17 (95% CI: −0.04, 0.38;p=0.112). However, after small sample studies were excluded in sensitivity analysis, the pooling mean difference of MPV was 0.32 (95% CI: 0.04, 0.60;p=0.03). In addition, the MPV was observed to be significantly higher in nonsurvivor groups after the third day of admission. On the subgroup analysis, although patient types (sepsis or mixed ICU) and study type (prospective or retrospective study) did not show any significant difference between groups, the difference of MPV was significantly difference on the unit which had mortality up to 30%.Conclusions. Initial values of MPV might not be used as a prognostic marker of mortality in critically ill patients. Subsequent values of MPV after the 3rd day and the lower mortality rate unit might be useful. However, the heterogeneity between studies is high.

scholarly journals Association of platelet count and platelet indices with cranial meningioma

2020 ◽  
pp. 123-126
Author(s):  
Yasar Karatas ◽  
Fatih Keskin ◽  
Mehmet Fatih Erdi ◽  
Bulent Kaya ◽  
Densel Arac ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Small Sample ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Healthy Group ◽  
Platelet Indices ◽  
Significant Difference

Introduction and Objectives: In this study, we aimed to investigate whether platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width  (PDW) values can be used as diagnostic markers in cranial meningiomas. Materials and Methods: The study included results of 29 patient and 47 healthy contributors. Based on pathologies, the patients were divided into two groups. The first group included meningioma patients and the second one included healthy individuals. Healthy contributors named control group. Platelet count and platelet indices were determined using Sysmex XN 550 haematology analyzer. The preoperative platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width  (PDW) values were recorded from the routine laboratory tests. Results: There was no statistically significant difference in PLT between the meningioma and healthy groups (p = 0.217). There was a statistically significant difference in PCT between the meningioma group and the healthy group (p = 0.002). There was a statistically significant difference in PDW between meningioma group and healthy group (p = 0.001). In terms of MPV, there was a statistically significant difference between meningioma group and the healthy group (p = 0.001) Conclusion: Platelet count and indices are easily available in the routine blood tests. Despite the retrospective design and small sample size, our findings suggest that altered MPV, PDW and PCT levels might serve as potential biomarkers for the diagnosis of meningiomas.

Platelet Size and Volume Distribution Measured by Automated Platelet Analyzer

Cephalalgia ◽  
1992 ◽  
Vol 12 (5) ◽  
pp. 321-322 ◽  
Author(s):  
A Pradalier ◽  
N Abuaf ◽  
JM Launay ◽  
D Vincent
Keyword(s):  
Mean Platelet Volume ◽  
Migraine Without Aura ◽  
Normal Subjects ◽  
Volume Distribution ◽  
Platelet Volume ◽  
Platelet Counts ◽  
Platelet Size ◽  
Hematology Analyzer ◽  
Automated Hematology Analyzer

Thirty migraine without aura patients between attacks, 10 other during a migraine without aura attack and 30 normal subjects without headache were studied for platelet size and volume distribution using a new quantitative automated hematology analyzer (Coulter STKS). Platelet histograms, platelet counts and mean platelet volume were not significantly different in the three populations.

scholarly journals Reference Intervals of Reticulated Platelets and Other Platelet Parameters and Their Associations

2013 ◽  
Vol 137 (11) ◽  
pp. 1635-1640 ◽  
Author(s):  
Johannes J. M. L. Hoffmann ◽  
Nicole M. A. van den Broek ◽  
Joyce Curvers
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Reference Intervals ◽  
Reference Ranges ◽  
Platelet Volume ◽  
Distribution Width ◽  
Normal Platelet ◽  
Reticulated Platelets ◽  
Automated Method ◽  
Hematology Analyzer

Context.—Reticulated platelets are platelets recently released from the bone marrow, and they can serve as a noninvasive indicator of recent megakaryopoietic activity. Widespread clinical use has been hampered by laborious methods and lack of standardization. Recently, a fully automated method was released on the Abbott CELL-DYN Sapphire hematology analyzer. Objective.—To establish reference ranges for reticulated platelets. Secondary aims were to investigate associations between reticulated platelets and other platelet parameters like mean platelet volume, plateletcrit, and platelet distribution width. Design.—Reticulated platelets and other platelet parameters were measured in an unselected cohort of 8089 subjects visiting a primary health care laboratory. The reticulated platelet data were analyzed using the Bhattacharya technique. In addition, a nonparametric method was used in selected subjects with normal platelet counts for providing reference ranges. Results.—Reticulated platelets ranged from 0.4% to 6.0% or from 1 to 18 × 103/μL. Reticulated platelets increased significantly with the subjects' age. Statistically, males had slightly higher values than females, but the differences were negligible. Reticulated platelets were positively correlated with platelet count and negatively with mean platelet volume. Conclusions.—Reference ranges have been established for reticulated platelets as measured on the CELL-DYN Sapphire hematology analyzer. There were no relevant differences between the sexes, but there was a clear effect of age. An individual's reticulated platelets are associated with the platelet count as well as mean platelet volume.

Klinische und labordiagnostische Parameter bei 21 Hunden mit primärer immunvermittelter Thrombozytopenie

2011 ◽  
Vol 39 (01) ◽  
pp. 17-24 ◽  
Author(s):  
H. J. Schuberth ◽  
R. Mischke ◽  
B. Dircks
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Klinische Relevanz

Zusammenfassung Gegenstand und Ziel: Charakterisierung von klinischen und labordiagnostischen Parametern sowie Therapie und Krankheitsverlauf bei Hunden mit einer angenommenen primären immunvermittelten Thrombozytopenie (pIMT) und Identifizierung möglicher Besonderheiten im Vergleich zu Hunden mit einer sekundären immunvermittelten Thrombozytopenie (sIMT). Material und Methoden: Retrospektive Auswertung von Patientendaten thrombozytopenischer Hunde, bei denen plättchengebundene Antikörper mittels Durchflusszytometrie nachgewiesen wurden. Ergebnisse: Dreizehn der 21 Hunde (62%) mit einer pIMT waren männlich. Das mittlere Alter bei Erstvorstellung betrug 6,6 Jahre (1,6–13,5 Jahre [Median; Minimum–Maximum]). Blutungen, hauptsächlich in Form von Haut- und Schleimhautblutungen, lagen bei 18 Hunden (86%) vor. Neunzehn Hunde (91%) wiesen eine Thrombozytenzahl unter 20000/μl auf. Bei allen Hunden mit einer pIMT ergab sich ein mittleres Thrombozytenvolumen (mean platelet volume, MPV) im oder unter dem Referenzbereich. In nahezu allen Fällen bestand eine gesteigerte Megakaryopoeseaktivität. Der Vergleich zweier Therapieregime (Prednisolon versus Prednisolon und Azathioprin) zeigte keinen signifikanten Unterschied bezüglich der Zeit bis zum Erreichen einer Thrombozytenzahl im Referenzbereich. Zwischen Patienten mit pIMT oder sIMT ließ sich im Hinblick auf Alter und Geschlecht kein signifikanter Unterschied feststellen. Bei Hunden mit einer pIMT waren Thrombozytenzahl und MPV signifikant niedriger und die Megakaryopoeseaktivität signifikant häufiger erhöht. Schlussfolgerung und klinische Relevanz: Bei Hunden, die plättchengebundene Antikörper und zusätzlich eine schwere Thrombozytopenie, ein niedriges MPV und eine gesteigerte Megakaryopoeseaktivität aufweisen, ist eine pIMT naheliegend.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

Is there any effect of the treatment on mean platelet volume in patients with hypothyroidism and hyperthyroidism?

2015 ◽  
Author(s):  
Yildiz Okuturlar ◽  
Aliye Soylu ◽  
Enver Tekin ◽  
Meral Mert ◽  
Ozlem Harmankaya ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume
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