Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

scholarly journals Comparing the Effects of Gamification and Teach-Back Training Methods on Adherence to a Therapeutic Regimen in Patients After Coronary Artery Bypass Graft Surgery: Randomized Clinical Trial (Preprint)

2020 ◽  
Author(s):  
Banafsheh Ghorbani ◽  
Alun C Jackson ◽  
Mohammad Noorchenarboo ◽  
Mohammad H Mandegar ◽  
Farshad Sharifi ◽  
...  
Keyword(s):  
Artery Bypass ◽  
Bypass Graft ◽  
Therapeutic Regimen ◽  
Control Group ◽  
Training Methods ◽  
Artery Bypass Graft ◽  
Control Groups ◽  
Dietary Regimen ◽  
The Mean ◽  
And Control

BACKGROUND Patients undergoing coronary artery bypass graft surgery (CABGS) may fail to adhere to their treatment regimen for many reasons. Among these, one of the most important reasons for nonadherence is the inadequate training of such patients or training using inappropriate methods. OBJECTIVE This study aimed to compare the effect of gamification and teach-back training methods on adherence to a therapeutic regimen in patients after CABGS. METHODS This randomized clinical trial was conducted on 123 patients undergoing CABGS in Tehran, Iran, in 2019. Training was provided to the teach-back group individually. In the gamification group, an app developed for the purpose was installed on each patient’s smartphone, with training given via this device. The control group received usual care, or routine training. Adherence to the therapeutic regimen was assessed using a questionnaire on adherence to a therapeutic regimen (physical activity and dietary regimen) and an adherence scale as a pretest and a 1-month posttest. RESULTS One-way analysis of variance (ANOVA) for comparing the mean scores of teach-back and gamification training methods showed that the mean normalized scores for the dietary regimen (<i>P</i>&lt;.001, <i>F</i>=71.80), movement regimen (<i>P</i>&lt;.001, <i>F</i>=124.53), and medication regimen (<i>P</i>&lt;.001, <i>F</i>=9.66) before and after intervention were significantly different between the teach-back, gamification, and control groups. In addition, the results of the Dunnett test showed that the teach-back and gamification groups were significantly different from the control group in all three treatment regimen methods. There was no statistically significant difference in adherence to the therapeutic regimen between the teach-back and control groups. CONCLUSIONS Based on the results of this study, the use of teach-back and gamification training approaches may be suggested for patients after CABGS to facilitate adherence to the therapeutic regimen. CLINICALTRIAL Iranian Registry of Clinical Trials IRCT20111203008286N8; https://en.irct.ir/trial/41507

scholarly journals Effects of Preoperative Mean Platelet Volume on Early Outcomes of Patients after Conventional Coronary Artery Bypass Graft Surgery

2016 ◽  
Vol 12 (1) ◽  
pp. 53-56
Author(s):  
Md Amirul Hasan ◽  
Md Abul Quashem ◽  
Sharmin Jahan
Keyword(s):  
Coronary Artery ◽  
Adverse Events ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Conventional Coronary Artery Bypass

Introduction: The Mean Platelet Volume (MPV) is a marker of platelet size with increased platelet activation. An elevated MPV is associated with major cardiac adverse events after Coronary Artery Bypass Graft (CABG) surgery. Effect of preoperative MPV on outcome of in-hospital patients after coronary artery bypass graft surgery was investigated in this study. Objective: To investigate the association of preoperative MPV with in-hospital outcome of patients after CABG surgery. Materials and Methods: An observational prospective study was carried out in the Department of Cardiovascular Surgery, National Institute of Cardiovascular Diseases (NICVD), Dhaka during the period from July 2012 to June 2014. Preoperative mean platelet volume was obtained prospectively in 81 consecutive patients undergoing conventional coronary artery bypass surgery. The patients were divided into two groups according to normal and elevated MPV at 10.60 femtolitre (fL) cut off level. Postoperative mortality and major adverse events were recorded in the early postoperative period. Results: Combined adverse events including post operative Myocardial Infarction (MI), arrhythmia, bleeding and death occurred in 27 patients (33.3%) during the early follow-up. The preoperative mean platelet volume levels were found to be associated with postoperative adverse events (p<0.05). In multivariate logistic regression models, the preoperative mean platelet volume levels was found strong independent predictor of combined adverse events after surgery (OR 1.968, p=0.008). Conclusion: Mean platelet volume is simple, readily available and cost effective tool and useful in predicting the postoperative adverse events in patients undergoing coronary artery bypass graft surgery. Journal of Armed Forces Medical College Bangladesh Vol.12(1) 2016: 53-56

scholarly journals Comparing the Effects of Gamification and Teach-Back Training Methods on Adherence to a Therapeutic Regimen in Patients After Coronary Artery Bypass Graft Surgery: Randomized Clinical Trial

10.2196/22557 ◽  
2021 ◽  
Vol 23 (12) ◽  
pp. e22557
Author(s):  
Banafsheh Ghorbani ◽  
Alun C Jackson ◽  
Mohammad Noorchenarboo ◽  
Mohammad H Mandegar ◽  
Farshad Sharifi ◽  
...  
Keyword(s):  
Artery Bypass ◽  
Bypass Graft ◽  
Therapeutic Regimen ◽  
Control Group ◽  
Training Methods ◽  
Artery Bypass Graft ◽  
Control Groups ◽  
Dietary Regimen ◽  
The Mean ◽  
And Control

Background Patients undergoing coronary artery bypass graft surgery (CABGS) may fail to adhere to their treatment regimen for many reasons. Among these, one of the most important reasons for nonadherence is the inadequate training of such patients or training using inappropriate methods. Objective This study aimed to compare the effect of gamification and teach-back training methods on adherence to a therapeutic regimen in patients after CABGS. Methods This randomized clinical trial was conducted on 123 patients undergoing CABGS in Tehran, Iran, in 2019. Training was provided to the teach-back group individually. In the gamification group, an app developed for the purpose was installed on each patient’s smartphone, with training given via this device. The control group received usual care, or routine training. Adherence to the therapeutic regimen was assessed using a questionnaire on adherence to a therapeutic regimen (physical activity and dietary regimen) and an adherence scale as a pretest and a 1-month posttest. Results One-way analysis of variance (ANOVA) for comparing the mean scores of teach-back and gamification training methods showed that the mean normalized scores for the dietary regimen (P<.001, F=71.80), movement regimen (P<.001, F=124.53), and medication regimen (P<.001, F=9.66) before and after intervention were significantly different between the teach-back, gamification, and control groups. In addition, the results of the Dunnett test showed that the teach-back and gamification groups were significantly different from the control group in all three treatment regimen methods. There was no statistically significant difference in adherence to the therapeutic regimen between the teach-back and control groups. Conclusions Based on the results of this study, the use of teach-back and gamification training approaches may be suggested for patients after CABGS to facilitate adherence to the therapeutic regimen. Trial Registration Iranian Registry of Clinical Trials IRCT20111203008286N8; https://en.irct.ir/trial/41507

Time-Varying Risk Factors for Long-Term Mortality After Coronary Artery Bypass Graft Surgery

2006 ◽  
Vol 81 (3) ◽  
pp. 793-799 ◽  
Author(s):  
Dexiang Gao ◽  
Gary K. Grunwald ◽  
John S. Rumsfeld ◽  
Lynn Schooley ◽  
Todd MacKenzie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Time Varying ◽  
Artery Bypass Graft ◽  
Long Term Mortality

Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery

2012 ◽  
Vol 164 (5) ◽  
pp. 779-785 ◽  
Author(s):  
Camilla Lund Søraas ◽  
Charlotte Friis ◽  
Kristin Victoria Tunheim Engebretsen ◽  
Leiv Sandvik ◽  
Sverre Erik Kjeldsen ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Troponin T ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Creatine Kinase Mb ◽  
Long Term Mortality
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