scholarly journals Sphingosine Kinase 1(SphK1) – A Novel Marker for Cancer Risk Assessment in Oral Premalignancy

2021 ◽  
Vol 4 (1) ◽  
pp. 51-60
Author(s):  
Bodh Bikram Karki ◽  
Debao Wu ◽  
Jun Shen
Keyword(s):  
Risk Assessment ◽  
Squamous Cell Carcinoma ◽  
Cancer Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Oral Leukoplakia ◽  
Cancer Risk Assessment ◽  
Sphingosine Kinase 1

Introduction Head and neck cancer is the sixth most common cancer worldwide, resulting in approximately 550,000 diagnoses of new cases and 300,000 deaths per year globally. Overexpression of Sphingosine kinase - 1 (SphK1) is found in head and neck squamous cell carcinoma (HNSCC) from early to advanced stages and is associated with tumor progression, invasion, metastasis and poor prognosis. This study assesses the expression of sphingosine kinase - 1 (SphK1) in oral leukoplakia and oral squamous cell carcinoma (OSCC)  and suggests its role as a potential biomarker tool for cancer risk assessment in oral leukoplakia. Methods In this retrospective study, eighty-two (n = 82) archival formalin-fixed paraffin blocks consisting of 10 normal tongue mucosa (Group A), 42 cases of oral leukoplakia (Group B) and 30 cases of OSCCs (Group C) were selected and subjected to immunohistochemical staining for anti-rabbit SphK1 antibody. The three different groups were compared for the presence of Sphk1 expression. The clinicopathological parameters such as age, gender, habits, histopathology, and Sphk1 expression were analyzed and compared between the malignantly transformed leukoplakia with untransformed leukoplakia. Results Positive SphK1 expression was found in 18 out of 42 (42.9 %) cases of oral leukoplakia and 17 out of 30 (56.7 %) cases of OSCCs while there was no SphK1 expression in normal tongue mucosa. The expression of SphK1 among three different groups of tissue samples was statistically significant (P = 0.007). The correlation between the malignant transformed and untransformed leukoplakia lesion with respect to SphK1 expression was also found to be statistically significant (P= 0.007) Conclusions Positive SphK1 expression in oral leukoplakia is suggestive of an increased risk for malignant transformation which can be used as a biomarker tool. Higher SPHK1 expression in the OSCC may suggest an important role in the early stages of tumorigenesis.

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition

Head & Neck ◽  
2011 ◽  
Vol 33 (2) ◽  
pp. 178-188 ◽  
Author(s):  
Uttam K. Sinha ◽  
Victor J. Schorn ◽  
Christian Hochstim ◽  
Steven B. Chinn ◽  
Sutao Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Radiation Sensitivity ◽  
Neck Squamous Cell Carcinoma ◽  
Sphingosine Kinase 1

Phospho-Sphingosine Kinase 1 Expression in Lymphatic Spread of Esophageal Squamous Cell Carcinoma

2019 ◽  
Vol 234 ◽  
pp. 123-131 ◽  
Author(s):  
Mariko Nemoto ◽  
Hiroshi Ichikawa ◽  
Masayuki Nagahashi ◽  
Takaaki Hanyu ◽  
Takashi Ishikawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Lymphatic Spread ◽  
Sphingosine Kinase 1

scholarly journals Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer

2021 ◽  
Vol 14 ◽  
pp. 2632010X2098853
Author(s):  
Nozomu Motono ◽  
Yoshimichi Ueda ◽  
Miyako Shimasaki ◽  
Shun Iwai ◽  
Yoshihito Iijima ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Prognostic Impact ◽  
Sphingosine Kinase 1 ◽  
Invasive Adenocarcinoma ◽  
Ki 67 ◽  
Positive Correlation

Bioactive sphingolipid is clearly relevant to lung physiology. The relationship of the bioactive sphingolipid pathway to pulmonary disease has been studied in cellular, tissue, and animal model, including lung cancer models. The samples of 53 patients diagnosed with nonsmall cell lung carcinoma (NSCLC) between June 2009 and May 2014 at our hospital were analyzed. Immunohistochemical (IHC) analysis was performed. The degree of immunostaining was reviewed and scored. Using this method of assessment, we evaluated the IHC score of sphingosine kinase 1 (SPHK1), vimentin, E-cadherin, and Ki-67. Both invasive adenocarcinoma cell and squamous cell carcinoma cell were well stained by SPHK1, and fibroblasts were also well stained by SPHK1. Although the IHC score of SPHK1 was not significantly differed between invasive adenocarcinoma and squamous cell carcinoma, the IHC scores of fibroblast, vimentin, and Ki-67 were higher in squamous cell carcinoma than invasive adenocarcinoma. Correlation among IHC scores in each of invasive adenocarcinoma and squamous cell carcinoma was performed. SPHK1 had positive correlation with both fibroblast and Ki-67, and fibroblast and Ki-67 had also positive correlation in invasive adenocarcinoma. On the contrary, SPHK1 had no significant correlation with fibroblast, and had negative correlation with Ki-67 in squamous cell carcinoma. Although there was not significant prognostic difference in SPHK1 score ( P = .09), IHC score high group tended to be worse on relapse-free survival. SPHK1 might be prognostic factor in lung-invasive adenocarcinoma and novel target for drug against lung-invasive adenocarcinoma.

scholarly journals Evaluation of Podoplanin in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Scientifica ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ashok Patil ◽  
Kishor Patil ◽  
Suyog Tupsakhare ◽  
Mahesh Gabhane ◽  
Shrikant Sonune ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Leukoplakia ◽  
Severe Dysplasia ◽  
Podoplanin Expression ◽  
Poorly Differentiated ◽  
One Way Anova

Background. Recent studies have demonstrated that podoplanin was expressed in some dysplastic lesions adjacent to primary oral cancers suggesting that podoplanin expression may occur in early oral tumorigenesis and lymphangiogenesis and therefore is related to tumor growth. The purpose of this study is to determine the role of podoplanin as a biomarker for cancer risk assessment in oral leukoplakia and correlation of podoplanin expression with grades of oral squamous cell carcinoma (OSCC).Materials and Methods. In the present retrospective study, podoplanin expression was investigated immunohistochemically in 40 patients each of oral leukoplakia and OSCC. The scores were analyzed statistically using one-way ANOVA test followed by Tukey HSD.Results. By applying one-way ANOVA test, there was a highly significant increase of the podoplanin expression from mild to severe dysplasia and from well to poorly differentiated OSCC (P<0.01). Statistically highly significant difference was present between scores of mild to moderate dysplasia, moderate to severe dysplasia, well to poorly differentiated OSCC, and moderately to poorly differentiated OSCC (Tukey HSD test,P<0.01).Conclusion. Podoplanin can be used as a biomarker for early oral tumorigenesis and for malignant transformation risk assessment of premalignant lesions and as a tumor progression biomarker for advanced grades of OSCC.

scholarly journals A Novel E2F/Sphingosine Kinase 1 Axis Regulates Anthracycline Response in Squamous Cell Carcinoma

2014 ◽  
Vol 21 (2) ◽  
pp. 417-427 ◽  
Author(s):  
Mehlika Hazar-Rethinam ◽  
Lilia Merida de Long ◽  
Orla M. Gannon ◽  
Eleni Topkas ◽  
Samuel Boros ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1
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