scholarly journals The Effects of Delayed Fluid Resuscitation on Lung Oxidative Stress and Antioxidant Vitamin Levels in Controlled Hemorrhagic Shock: An Experimental Study

2015 ◽  
Vol 7 (2) ◽  
pp. 429-438
Author(s):  
Hacı Ahmet Bircan
2007 ◽  
Vol 63 (4) ◽  
pp. 798-804 ◽  
Author(s):  
Yuan-Qiang Lu ◽  
Xiu-Jun Cai ◽  
Lin-Hui Gu ◽  
Qi Wang ◽  
Wei-Dong Huang ◽  
...  

2015 ◽  
Vol 29 (11) ◽  
pp. 1798-1805 ◽  
Author(s):  
Najeeb Latief ◽  
Shikha Anand ◽  
Madhu Cholenahalli Lingaraju ◽  
Venkanna Balaganur ◽  
Nitya Nand Pathak ◽  
...  

Resuscitation ◽  
1994 ◽  
Vol 28 (2) ◽  
pp. S13
Author(s):  
A. Capone ◽  
P. Safar ◽  
D. Crippen ◽  
Y. Leonov ◽  
S. Tisherman ◽  
...  

2016 ◽  
Vol 311 (1) ◽  
pp. G180-G191 ◽  
Author(s):  
Geeta Rao ◽  
Vivek R. Yadav ◽  
Shanjana Awasthi ◽  
Pamela R. Roberts ◽  
Vibhudutta Awasthi

Gut barrier dysfunction is the major trigger for multiorgan failure associated with hemorrhagic shock (HS). Although the molecular mediators responsible for this dysfunction are unclear, oxidative stress-induced disruption of proteostasis contributes to the gut pathology in HS. The objective of this study was to investigate whether resuscitation with nanoparticulate liposome-encapsulated hemoglobin (LEH) is able to restore the gut proteostatic mechanisms. Sprague-Dawley rats were recruited in four groups: control, HS, HS+LEH, and HS+saline. HS was induced by withdrawing 45% blood, and isovolemic LEH or saline was administered after 15 min of shock. The rats were euthanized at 6 h to collect plasma and ileum for measurement of the markers of oxidative stress, unfolded protein response (UPR), proteasome function, and autophagy. HS significantly increased the protein and lipid oxidation, trypsin-like proteasome activity, and plasma levels of IFNγ. These effects were prevented by LEH resuscitation. However, saline was not able to reduce protein oxidation and plasma IFNγ in hemorrhaged rats. Saline resuscitation also suppressed the markers of UPR and autophagy below the basal levels; the HS or LEH groups showed no effect on the UPR and autophagy. Histological analysis showed that LEH resuscitation significantly increased the villus height and thickness of the submucosal and muscularis layers compared with the HS and saline groups. Overall, the results showed that LEH resuscitation was effective in normalizing the indicators of proteostasis stress in ileal tissue. On the other hand, saline-resuscitated animals showed a decoupling of oxidative stress and cellular protective mechanisms.


2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  

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