scholarly journals The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model

2021 ◽  
Author(s):  
Yusuke Fukuo ◽  
Yoshihide Hattori ◽  
Shinji Kawabata ◽  
Hideki Kashiwagi ◽  
Takuya Kanemitsu ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Tumor Model ◽  
Therapeutic Effects ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

scholarly journals The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model

Biology ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 437
Author(s):  
Yusuke Fukuo ◽  
Yoshihide Hattori ◽  
Shinji Kawabata ◽  
Hideki Kashiwagi ◽  
Takuya Kanemitsu ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Boron Concentration ◽  
Tumor Model ◽  
Boron Compound ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

Background: The development of effective boron compounds is a major area of research in the study of boron neutron capture therapy (BNCT). We created a novel boron compound, boronophenylalanine–amide alkyl dodecaborate (BADB), for application in BNCT and focused on elucidating how it affected a rat brain tumor model. Methods: The boron concentration of F98 rat glioma cells following exposure to boronophenylalanine (BPA) (which is currently being utilized clinically) and BADB was evaluated, and the biodistributions in F98 glioma-bearing rats were assessed. In neutron irradiation studies, the in vitro cytotoxicity of each boron compound and the in vivo corresponding therapeutic effect were evaluated in terms of survival time. Results: The survival fractions of the groups irradiated with BPA and BADB were not significantly different. BADB administered for 6 h after the termination of convection-enhanced delivery ensured the highest boron concentration in the tumor (45.8 μg B/g). The median survival time in the BADB in combination with BPA group showed a more significant prolongation of survival than that of the BPA group. Conclusion: BADB is a novel boron compound for BNCT that triggers a prolonged survival effect in patients receiving BNCT.

scholarly journals ET-5 Biological effects of simultaneous use of multiple drugs in neutron capture therapy using rat brain tumor model

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi4-vi4
Author(s):  
Shinji Kawabata ◽  
Hideki Kashiwagi ◽  
Kohei Yoshimura ◽  
Yusuke Fukuo ◽  
Ryo Hiramatsu ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Rat Brain ◽  
Neutron Capture ◽  
Biological Effects ◽  
Tumor Model ◽  
Neutron Capture Therapy ◽  
Rat Brain Tumor ◽  
Brain Tumor Model ◽  
Multiple Drugs

Abstract The world’s first clinical trial of boron neutron capture therapy (BNCT), which treats malignant brain tumors with a single dose of neutron irradiation using multiple boron drugs simultaneously, was performed at our institution, and its excellent results have stimulated BNCT research around the world. BNCT is a particle irradiation therapy that biologically targets cancer cells, and is expected to be a “new option for cancer treatment” because it can deliver a dose of radiation at the cellular level. In the case of BNCT using a combination of multiple drugs, a method to appropriately consider the biological effects of the combination in the dose calculation has not been established. At present, BNCT based on an accelerator-based irradiation system and a boron drug (BPA) based on essential amino acids has been approved by the regulatory approval for head and neck cancer and has shown good results in brain tumors. As basic research, we have continued to develop new boron drugs, which will be essential in the future, and have explored the interpretation of the biological effects of multiple boron drugs in combination and the optimal conditions required for drug development. The survival curve of BNCT in a rat brain tumor model showed that the effect of the new drug alone was comparable to that of BPA, and the effect of the combination was improved, but the effect of the combination did not match the prediction of the combined biological effect derived from each drug. However, it has been found that the effect of the combination does not match the prediction based on the combination of biological effects derived from each drug. In other words, even if the equivalent X-ray equivalent dose (Gy-Eq) is calculated, the combined effect of some drugs exceeds the prediction, while the combined effect of other drugs is poor.

scholarly journals Therapeutic Effects of Holmium-166 Chitosan Complex in Rat Brain Tumor Model

2005 ◽  
Vol 46 (1) ◽  
pp. 51 ◽  
Author(s):  
Ryoong Huh ◽  
Yong Sook Park ◽  
Jong Doo Lee ◽  
Young Sun Chung ◽  
Yong Gou Park ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Rat Brain ◽  
Tumor Model ◽  
Therapeutic Effects ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

1989 ◽  
Vol 9 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Michihiro Kirikae ◽  
Mirko Diksic ◽  
Y. Lucas Yamamoto
Keyword(s):  
Protein Synthesis ◽  
Brain Tumor ◽  
Rat Brain ◽  
Brain Tissue ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

We examined the rate of glucose utilization and the rate of valine incorporation into proteins using 2-[18F]fluoro-2-deoxyglucose and L-[1-14C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. We found that in the implanted tumor the rate of valine incorporation into proteins was about 22 times and the rate of glucose utilization was about 1.5 times that in the contralateral cortex. (In the ipsilateral cortex, the tumor had a profound effect on glucose utilization but no effect on the rate of valine incorporation into proteins.) Our findings suggest that it is more useful to measure protein synthesis than glucose utilization to assess the effectiveness of antitumor agents and their toxicity to normal brain tissue. We compared two methods to estimate the rate of valine incorporation: “kinetic” (quantitation done using an operational equation and the average brain rate coefficients) and “washed slices” (unbound labeled valine removed by washing brain slices in 10% thrichloroacetic acid). The results were the same using either method. It would seem that the kinetic method can thus be used for quantitative measurement of protein synthesis in brain tumors and normal brain tissue using [11C]-valine with positron emission tomography.

Analysis and Distribution of Etoposide in Rat Brain Tumor Model: Intracarotid Versus Intracarotid with Angiotensin II—Induced Hypertension

1993 ◽  
Vol 11 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Hidenori Ogasawara ◽  
Tohru Uozumi ◽  
Katsuzo Kiya ◽  
Kaoru Kurisu ◽  
Takashi Mikami ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Angiotensin Ii ◽  
Rat Brain ◽  
Tumor Model ◽  
Induced Hypertension ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

scholarly journals Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model

Radiology ◽  
2020 ◽  
Vol 294 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Philippe Robert ◽  
Véronique Vives ◽  
Anne-Laure Grindel ◽  
Stéphane Kremer ◽  
Guillaume Bierry ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Contrast Agent ◽  
Rat Brain ◽  
Tumor Model ◽  
Rat Brain Tumor ◽  
Brain Tumor Model ◽  
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