Characterization and Drug Sensitivity of Four Newly Established Colon Adenocarcinoma Cell Lines to Antifolate Inhibitors of Thymidylate Synthase

Author(s):  
G.S.A. Longo ◽  
J. Izzo ◽  
R. Gorlick ◽  
D. Banerjee ◽  
S.C. Jhanwar ◽  
...  
1996 ◽  
Vol 226 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Marie Françoise Bernet-Camard ◽  
Marie Hélène Coconnier ◽  
Sylvie Hudault ◽  
Alain L. Servin

2001 ◽  
Vol 164 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Greogory Merritt ◽  
Elias T. Aliprandis ◽  
Francesco Prada ◽  
Basil Rigas ◽  
Khosrow Kashfi

1995 ◽  
Vol 63 (4) ◽  
pp. 551-559 ◽  
Author(s):  
Marja-Leena Majuri ◽  
Ritva Niemelä ◽  
Sinikka Tiisala ◽  
Ossi Renkonen ◽  
Risto Renkonen

2014 ◽  
Vol 9 (3) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Ewa Seweryn ◽  
Michał Glehsk ◽  
Kamila Środa-Pomianek ◽  
Ireneusz Ceremuga ◽  
Maciej Włodarczyk ◽  
...  

Four types of aescin that are available on the pharmaceutical market, β-aescin crystalline, β-aescin amorphous, β-aescin sodium and aescin polysulfate, have been analyzed for their cytotoxic effects on human colon adenocarcinoma (LoVo) and doxorubicin-resistant human colon adenocarcinoma cell lines (LoVo/Dx). Their cytotoxic activities were evaluated by sulforhodamine B (SRB) and methyl tetrazolium (MTT) assays. All four types of aescin exerted strong dose-dependent cytotoxicity to LoVo and, to a lesser degree, LoVo/Dx cell lines. The IC50 value for the LoVo/Dx cell line was higher, but still dose-dependent. Results from both assays demonstrated that β-aescin crystalline has the most cytotoxic activity toward human colon adenocarcinoma cell lines.


1995 ◽  
Vol 23 (4) ◽  
pp. 529S-529S ◽  
Author(s):  
B. JAN-WILLEM VAN KLINKEN ◽  
ESMERALDA OUSSOREN ◽  
JAN-JOHAN WEENINK ◽  
HANS A. BÜLLER ◽  
JAN DEKKER ◽  
...  

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