Depression in Amputation Patients

2021 ◽  
Vol 1 (4) ◽  
pp. 67-70
Author(s):  
Arazy Gifta Prima
Keyword(s):  
Depressive Disorders ◽  
Lower Limbs ◽  
Phantom Limb ◽  
Limb Amputation ◽  
Major Depressive ◽  
Number Of Patients ◽  
Major Depressive Disorders ◽  
The Common ◽  
General Mobility

Amputation alters the quality of life with an undeniable negative somatic and functional impact. The patient’s general mobility is impaired and there is an increase in metabolic needs as well as pain and discomfort. Etiologies are quite diverse: essentially vascular pathologies (74%) for the lower limbs and trauma related (61%) for the upper limbs. Thus, an important number of patients have to face amputation-related consequences. Pain (stump, phantom limb, back pain) is frequently described in 65 to 75% of patients after an amputation as well as the common onset of major depressive disorders for 35% of them. With the incidence of depression after limb amputation increasing in the patients, we sought to summarize the management of depression in amputation patients.

scholarly journals Depression in Amputation Patients

2021 ◽  
Vol 1 (4) ◽  
pp. 67-70
Author(s):  
Arazy Gifta Prima
Keyword(s):  
Depressive Disorders ◽  
Lower Limbs ◽  
Phantom Limb ◽  
Limb Amputation ◽  
Major Depressive ◽  
Number Of Patients ◽  
Major Depressive Disorders ◽  
The Common ◽  
General Mobility

Amputation alters the quality of life with an undeniable negative somatic and functional impact. The patient’s general mobility is impaired and there is an increase in metabolic needs as well as pain and discomfort. Etiologies are quite diverse: essentially vascular pathologies (74%) for the lower limbs and trauma related (61%) for the upper limbs. Thus, an important number of patients have to face amputation-related consequences. Pain (stump, phantom limb, back pain) is frequently described in 65 to 75% of patients after an amputation as well as the common onset of major depressive disorders for 35% of them. With the incidence of depression after limb amputation increasing in the patients, we sought to summarize the management of depression in amputation patients.

The quality of life in dysthymic and major depressive disorders

1997 ◽  
Vol 42 (1) ◽  
pp. 256S
Author(s):  
F. Cavaglia ◽  
A. Matos-Pires ◽  
M. Botelho ◽  
M. Oliveira ◽  
F. Arriaga
Keyword(s):  
Quality Of Life ◽  
Depressive Disorders ◽  
Major Depressive ◽  
Major Depressive Disorders

Feasibility of pharmacotherapy in HIV-related affective spectrum disorders: an open trial with fluvoxamine

1996 ◽  
Vol 11 (1) ◽  
pp. 40-45 ◽  
Author(s):  
P Perretta ◽  
C Nisita ◽  
E Zaccagnini ◽  
C Lorenzetti ◽  
A Nuccorini ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Open Study ◽  
Marked Improvement ◽  
Depressive Disorders ◽  
Major Depressive ◽  
Minimum Period ◽  
Number Of Patients ◽  
Major Depressive Disorders ◽  
Spectrum Disorders ◽  
Serotonergic Antidepressant

SummaryAmong HIV patients treated for AIDS-related adjustment, major depressive disorders and other affective disorders, we assessed in an open study the feasibility of using a serotonergic antidepressant (fluvoxamine). Thirty-five seropositive patients with the above conditions (22 men and 13 women) were followed over a minimum period of four weeks. At the end of the treatment, a large number of patients (77%) showed marked improvement. “Nuclear” depressive and anxiety symptoms remitted, while the “somatic” ones seemed less sensitive to treatment. Treatment had to be terminated prematurely due to side effects in only two patients (6%).

Psychological Interventions for Cognitive Dysfunction in Major Depressive Disorder

2019 ◽  
pp. 241-256
Author(s):  
Claudia Woolf ◽  
Loren Mowszowski ◽  
Sharon Naismith
Keyword(s):  
Depressive Disorders ◽  
Evidence Base ◽  
Neuropsychological Impairment ◽  
Major Depressive ◽  
Neuropsychological Dysfunction ◽  
Symptoms Of Depression ◽  
Full Remission ◽  
Affective Symptoms ◽  
Major Depressive Disorders

Major depressive disorders (MDD) are common and disabling, and are linked to functional impairment and increased mortality. While current treatments for MDD are moderately effective, ultimately up to one-third of patients do not achieve full remission. Interestingly, while affective symptoms of depression resolve with the resolution of a depressive episode, cognitive or neuropsychological impairment persists, and has been identified as one of the most prominent predictors of ongoing disability, reduced quality of life, and illness recurrence. Yet available treatments in MDD do not typically address neuropsychological dysfunction. Cognitive training, however, despite a small and heterogeneous evidence base, represents a promising and novel therapeutic intervention for neuropsychological impairment in MDD, which may yield neuropsychological, affective, and functional benefits.

scholarly journals The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

2021 ◽  
Vol 22 (11) ◽  
pp. 5495
Author(s):  
Felipe Borges Almeida ◽  
Graziano Pinna ◽  
Helena Maria Tannhauser Barros
Keyword(s):  
Hpa Axis ◽  
Depressive Disorders ◽  
Post Traumatic Stress ◽  
Major Depressive ◽  
Physiological Adaptations ◽  
Suppression Test ◽  
Post Traumatic ◽  
Major Depressive Disorders ◽  
Cortisol Release

Under stressful conditions, the hypothalamic-pituitary-adrenal (HPA) axis acts to promote transitory physiological adaptations that are often resolved after the stressful stimulus is no longer present. In addition to corticosteroids (e.g., cortisol), the neurosteroid allopregnanolone (3α,5α-tetrahydroprogesterone, 3α-hydroxy-5α-pregnan-20-one) participates in negative feedback mechanisms that restore homeostasis. Chronic, repeated exposure to stress impairs the responsivity of the HPA axis and dampens allopregnanolone levels, participating in the etiopathology of psychiatric disorders, such as major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). MDD and PTSD patients present abnormalities in the HPA axis regulation, such as altered cortisol levels or failure to suppress cortisol release in the dexamethasone suppression test. Herein, we review the neurophysiological role of allopregnanolone both as a potent and positive GABAergic neuromodulator but also in its capacity of inhibiting the HPA axis. The allopregnanolone function in the mechanisms that recapitulate stress-induced pathophysiology, including MDD and PTSD, and its potential as both a treatment target and as a biomarker for these disorders is discussed.

scholarly journals Development of a Nomogram for Predicting Depression in the Elderly Using Patient Health Questionnaire-9 among a Nationwide Sample of Korean Elderly

2021 ◽  
Vol 11 (7) ◽  
pp. 645
Author(s):  
Haewon Byeon
Keyword(s):  
Depressive Disorders ◽  
The Elderly ◽  
Subjective Health ◽  
Moderate Intensity ◽  
Subjective Health Status ◽  
Major Depressive ◽  
Moderate Intensity Physical Activity ◽  
Patient Health ◽  
Intensity Physical Activity ◽  
Major Depressive Disorders

This cross-sectional study developed a nomogram that could allow medical professionals in the primary care setting to easily and visually confirm high-risk groups of depression. This study analyzed 4011 elderly people (≥60 years old) who completed a health survey, blood pressure, physical measurement, blood test, and a standardized depression screening test. A major depressive disorder was measured using the Korean version of the Patient Health Questionnaire (PHQ-9). This study built a model for predicting major depressive disorders using logistic regression analysis to understand the relationship of each variable with major depressive disorders. In the result, the prevalence of depression measured by PHQ-9 was 6.8%. The results of multiple logistic regression analysis revealed that the major depressive disorder of the elderly living alone was significantly (p < 0.05) related to monthly mean household income, the mean frequency of having breakfast per week for the past year, moderate-intensity physical activity, subjective level of stress awareness, and subjective health status. The results of this study implied that it would be necessary to continuously monitor these complex risk factors such as household income, skipping breakfast, moderate-intensity physical activity, subjective stress, and subjective health status to prevent depression among older adults living in the community.

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