Zingerone Alleviates Myocardial Ischemia/Reperfusion Injury
2021 ◽
Vol 19
(4)
◽
pp. 543-549
Keyword(s):
Using a rat model, we have explored the underlying mechanism of ischemia/reperfusion (I/R)-mediated myocardial infarction and assessed the protective potential of zingerone. The results show that zingerone exhibits not only the myocardial protective effect, but also antioxidative and anti-inflammatory effects by suppression of markers of oxidation and proinflammatory cytokine release. Zingerone promotes protective effects against I/R-induced myocardial infarction by regulating Nrf2/HO-1 and NF-κB signaling pathways. These findings provide novel insights into the effects of zingerone on the cardioprotective mechanism of myocardial injury after I/R and may open new avenues for myocardial infarction treatment.
2018 ◽
Vol 2018
◽
pp. 1-13
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2013 ◽
Vol 2013
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pp. 1-11
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2000 ◽
Vol 279
(1)
◽
pp. H329-H338
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2019 ◽
Vol 2019
◽
pp. 1-12
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2020 ◽
Vol 27
(3)
◽
pp. 251-258